Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade
Internal-tamponade agents are crucial surgical adjuncts in vitreoretinal surgery. Clinically used endotamponade agents act through buoyancy forces, yet can result in prolonged post-operative positioning, temporary loss of vision, raised intra-ocular pressure, cataract formation or the need for addit...
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| Veröffentlicht in: | Nature biomedical engineering 2019-08, Vol.3 (8), p.598-610 |
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| creator | Liu, Zengping Liow, Sing Shy Lai, Siew Li Alli-Shaik, Asfa Holder, Graham E. Parikh, Bhav Harshad Krishnakumar, Subramanian Li, Zibiao Tan, Mein Jin Gunaratne, Jayantha Barathi, Veluchamy Amutha Hunziker, Walter Lakshminarayanan, Rajamani Tan, Clement Woon Teck Chee, Caroline K. Zhao, Paul Lingam, Gopal Loh, Xian Jun Su, Xinyi |
| description | Internal-tamponade agents are crucial surgical adjuncts in vitreoretinal surgery. Clinically used endotamponade agents act through buoyancy forces, yet can result in prolonged post-operative positioning, temporary loss of vision, raised intra-ocular pressure, cataract formation or the need for additional removal surgery. Here, we describe a thermogelling polymer that provides an internal tamponade effect through surface tension and swelling counter-forces. We tested the long-term biocompatibility of the polymer endotamponade in rabbit vitrectomy models, and its surgical efficacy and biocompatibility in a non-human primate retinal-detachment model. We also show that, while the thermogel biodegrades during the three months following surgery, it promotes the reformation of a vitreous-like body that mimics the biophysical properties of the natural vitreous. The thermogelling endotamponade might serve as a long-term vitreous substitute.
A thermogelling polymer that acts as an internal tamponade can repair detached retinas and trigger the formation of a vitreous-like body, as shown in retinal-detachment rabbit and non-human-primate models. |
| doi_str_mv | 10.1038/s41551-019-0382-7 |
| format | Article |
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A thermogelling polymer that acts as an internal tamponade can repair detached retinas and trigger the formation of a vitreous-like body, as shown in retinal-detachment rabbit and non-human-primate models.</description><identifier>ISSN: 2157-846X</identifier><identifier>EISSN: 2157-846X</identifier><identifier>DOI: 10.1038/s41551-019-0382-7</identifier><identifier>PMID: 30962587</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/61/490 ; 631/61/54/990 ; 692/308/575 ; 82/51 ; 82/58 ; Animal models ; Animals ; Biocompatibility ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Cataracts ; Endotamponade - methods ; Gels - chemistry ; Humans ; Intraocular Pressure ; Macaca fascicularis ; Male ; Models, Animal ; Pain Management ; Polymers ; Rabbits ; Retina ; Retinal Detachment - surgery ; Surface Tension ; Surgery ; Tamponade ; Tonometry, Ocular ; Vitrectomy - methods ; Vitreoretinal Surgery - methods ; Vitreous Body - surgery</subject><ispartof>Nature biomedical engineering, 2019-08, Vol.3 (8), p.598-610</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2019</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e76cda61d4bc4e6084680e84147fe7dce12ed62ac6f545c2a8ea972085793fbc3</citedby><cites>FETCH-LOGICAL-c372t-e76cda61d4bc4e6084680e84147fe7dce12ed62ac6f545c2a8ea972085793fbc3</cites><orcidid>0000-0001-7477-0495 ; 0000-0001-9130-5712 ; 0000-0002-2578-293X ; 0000-0003-3835-8887 ; 0000-0002-5265-4933 ; 0000-0002-5473-3109 ; 0000-0001-8118-6502 ; 0000-0003-0047-5455</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41551-019-0382-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41551-019-0382-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30962587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zengping</creatorcontrib><creatorcontrib>Liow, Sing Shy</creatorcontrib><creatorcontrib>Lai, Siew Li</creatorcontrib><creatorcontrib>Alli-Shaik, Asfa</creatorcontrib><creatorcontrib>Holder, Graham E.</creatorcontrib><creatorcontrib>Parikh, Bhav Harshad</creatorcontrib><creatorcontrib>Krishnakumar, Subramanian</creatorcontrib><creatorcontrib>Li, Zibiao</creatorcontrib><creatorcontrib>Tan, Mein Jin</creatorcontrib><creatorcontrib>Gunaratne, Jayantha</creatorcontrib><creatorcontrib>Barathi, Veluchamy Amutha</creatorcontrib><creatorcontrib>Hunziker, Walter</creatorcontrib><creatorcontrib>Lakshminarayanan, Rajamani</creatorcontrib><creatorcontrib>Tan, Clement Woon Teck</creatorcontrib><creatorcontrib>Chee, Caroline K.</creatorcontrib><creatorcontrib>Zhao, Paul</creatorcontrib><creatorcontrib>Lingam, Gopal</creatorcontrib><creatorcontrib>Loh, Xian Jun</creatorcontrib><creatorcontrib>Su, Xinyi</creatorcontrib><title>Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade</title><title>Nature biomedical engineering</title><addtitle>Nat Biomed Eng</addtitle><addtitle>Nat Biomed Eng</addtitle><description>Internal-tamponade agents are crucial surgical adjuncts in vitreoretinal surgery. Clinically used endotamponade agents act through buoyancy forces, yet can result in prolonged post-operative positioning, temporary loss of vision, raised intra-ocular pressure, cataract formation or the need for additional removal surgery. Here, we describe a thermogelling polymer that provides an internal tamponade effect through surface tension and swelling counter-forces. We tested the long-term biocompatibility of the polymer endotamponade in rabbit vitrectomy models, and its surgical efficacy and biocompatibility in a non-human primate retinal-detachment model. We also show that, while the thermogel biodegrades during the three months following surgery, it promotes the reformation of a vitreous-like body that mimics the biophysical properties of the natural vitreous. The thermogelling endotamponade might serve as a long-term vitreous substitute.
A thermogelling polymer that acts as an internal tamponade can repair detached retinas and trigger the formation of a vitreous-like body, as shown in retinal-detachment rabbit and non-human-primate models.</description><subject>631/61/490</subject><subject>631/61/54/990</subject><subject>692/308/575</subject><subject>82/51</subject><subject>82/58</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Cataracts</subject><subject>Endotamponade - methods</subject><subject>Gels - chemistry</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Pain Management</subject><subject>Polymers</subject><subject>Rabbits</subject><subject>Retina</subject><subject>Retinal Detachment - surgery</subject><subject>Surface Tension</subject><subject>Surgery</subject><subject>Tamponade</subject><subject>Tonometry, Ocular</subject><subject>Vitrectomy - 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Clinically used endotamponade agents act through buoyancy forces, yet can result in prolonged post-operative positioning, temporary loss of vision, raised intra-ocular pressure, cataract formation or the need for additional removal surgery. Here, we describe a thermogelling polymer that provides an internal tamponade effect through surface tension and swelling counter-forces. We tested the long-term biocompatibility of the polymer endotamponade in rabbit vitrectomy models, and its surgical efficacy and biocompatibility in a non-human primate retinal-detachment model. We also show that, while the thermogel biodegrades during the three months following surgery, it promotes the reformation of a vitreous-like body that mimics the biophysical properties of the natural vitreous. The thermogelling endotamponade might serve as a long-term vitreous substitute.
A thermogelling polymer that acts as an internal tamponade can repair detached retinas and trigger the formation of a vitreous-like body, as shown in retinal-detachment rabbit and non-human-primate models.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30962587</pmid><doi>10.1038/s41551-019-0382-7</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-7477-0495</orcidid><orcidid>https://orcid.org/0000-0001-9130-5712</orcidid><orcidid>https://orcid.org/0000-0002-2578-293X</orcidid><orcidid>https://orcid.org/0000-0003-3835-8887</orcidid><orcidid>https://orcid.org/0000-0002-5265-4933</orcidid><orcidid>https://orcid.org/0000-0002-5473-3109</orcidid><orcidid>https://orcid.org/0000-0001-8118-6502</orcidid><orcidid>https://orcid.org/0000-0003-0047-5455</orcidid></addata></record> |
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| identifier | ISSN: 2157-846X |
| ispartof | Nature biomedical engineering, 2019-08, Vol.3 (8), p.598-610 |
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| subjects | 631/61/490 631/61/54/990 692/308/575 82/51 82/58 Animal models Animals Biocompatibility Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Cataracts Endotamponade - methods Gels - chemistry Humans Intraocular Pressure Macaca fascicularis Male Models, Animal Pain Management Polymers Rabbits Retina Retinal Detachment - surgery Surface Tension Surgery Tamponade Tonometry, Ocular Vitrectomy - methods Vitreoretinal Surgery - methods Vitreous Body - surgery |
| title | Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade |
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