Experimental study of rhBMP-2 chitosan nano-sustained release carrier-loaded PLGA/nHA scaffolds to construct mandibular tissue-engineered bone

•A novel PLGA/nHA/CS/rhBMP-2 scaffold complex was prepared, which effectively controlled the early burst effect of rhBMP-2.•The bone tissue engineering scaffold complex had good biocompatibility and induced osteogenic effects.•The bone tissue engineering scaffold complex successfully repaired the ex...

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Veröffentlicht in:	Archives of oral biology 2019-06, Vol.102, p.16-25
Hauptverfasser:	Deng, Nan, Sun, Jian, Li, Yali, Chen, Liqiang, Chen, Chen, Wu, Yutong, Wang, Zhihao, Li, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone morphogenetic protein Bone Morphogenetic Protein 2 Bone Regeneration Chitosan Delayed-Action Preparations Dentistry Drug delivery Mandible Nanoparticle Osteogenesis Rabbits Recombinant Proteins Scaffold Tissue Engineering Tissue regeneration Tissue Scaffolds Transforming Growth Factor beta
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