Improved in vivo detection of atherosclerotic plaques with a tissue factor-targeting magnetic nanoprobe
[Display omitted] Rupture of atherosclerotic plaques causes acute cardiovascular and cerebrovascular pathology. Tissue factor (TF) is a key factor that affects the development of atherosclerotic plaques and the formation of thrombus and thus constitutes a potential target for the detection of athero...
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| Veröffentlicht in: | Acta biomaterialia 2019-05, Vol.90, p.324-336 |
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| creator | Wei, Qiuzhe Wang, Jing Shi, Wei Zhang, Bo Jiang, Huiwen Du, Mengyi Mei, Heng Hu, Yu |
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Rupture of atherosclerotic plaques causes acute cardiovascular and cerebrovascular pathology. Tissue factor (TF) is a key factor that affects the development of atherosclerotic plaques and the formation of thrombus and thus constitutes a potential target for the detection of atherosclerotic plaques. In this study, the conjugation of the fusion protein ‘enhanced green fluorescent protein with the first epidermal growth factor domain’ (EGFP-EGF1) and superparamagnetic iron oxide nanoparticles (EGFP-EGF1-SPIONs) was explored for molecular imaging of TF-positive atherosclerotic plaques. EGFP-EGF1-SPIONs showed improved accuracy, superior contrast effects, and better cytocompatibility compared with common contrast agents in the detection of atherosclerotic plaques of apolipoprotein E knockout (ApoE−/−) mice using magnetic resonance imaging. In conclusion, EGFP-EGF1-SPION is a promising TF-targeting nanoprobe to precisely and specifically detect atherosclerotic plaques, which may improve molecular imaging diagnosis of cardiovascular and cerebrovascular events for the comprehensive evaluation of atherosclerosis.
Traditional methods can only display the status of atherosclerosis, but not forecast the progress of lesions efficiently. It remains challenging to evaluate the plaques specifically and sensitively. In this study, we constructed a tissue factor-targeted magnetic nanoprobe to specifically detect plaques by magnetic resonance imaging in vivo, which will improve the diagnostic technology for atherosclerotic plaques and offer molecular level guidance to treat atherosclerosis. Furthermore, this strategy has critical clinical significance on prevention, diagnosis and therapeutic evaluation of cardio-cerebral vascular events. |
| doi_str_mv | 10.1016/j.actbio.2019.04.014 |
| format | Article |
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Rupture of atherosclerotic plaques causes acute cardiovascular and cerebrovascular pathology. Tissue factor (TF) is a key factor that affects the development of atherosclerotic plaques and the formation of thrombus and thus constitutes a potential target for the detection of atherosclerotic plaques. In this study, the conjugation of the fusion protein ‘enhanced green fluorescent protein with the first epidermal growth factor domain’ (EGFP-EGF1) and superparamagnetic iron oxide nanoparticles (EGFP-EGF1-SPIONs) was explored for molecular imaging of TF-positive atherosclerotic plaques. EGFP-EGF1-SPIONs showed improved accuracy, superior contrast effects, and better cytocompatibility compared with common contrast agents in the detection of atherosclerotic plaques of apolipoprotein E knockout (ApoE−/−) mice using magnetic resonance imaging. In conclusion, EGFP-EGF1-SPION is a promising TF-targeting nanoprobe to precisely and specifically detect atherosclerotic plaques, which may improve molecular imaging diagnosis of cardiovascular and cerebrovascular events for the comprehensive evaluation of atherosclerosis.
Traditional methods can only display the status of atherosclerosis, but not forecast the progress of lesions efficiently. It remains challenging to evaluate the plaques specifically and sensitively. In this study, we constructed a tissue factor-targeted magnetic nanoprobe to specifically detect plaques by magnetic resonance imaging in vivo, which will improve the diagnostic technology for atherosclerotic plaques and offer molecular level guidance to treat atherosclerosis. Furthermore, this strategy has critical clinical significance on prevention, diagnosis and therapeutic evaluation of cardio-cerebral vascular events.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2019.04.014</identifier><identifier>PMID: 30954623</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Apolipoprotein E ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - metabolism ; Atherosclerosis - pathology ; Atherosclerotic plaque ; Biocompatibility ; Centenarians ; Conjugation ; Contrast agents ; Contrast Media - chemistry ; Contrast Media - pharmacokinetics ; Contrast Media - pharmacology ; Drug Delivery Systems ; EGFP-EGF1 ; Epidermal growth factor ; Fluorescence ; Fusion protein ; Green fluorescent protein ; Growth factors ; Iron oxides ; Magnetic Resonance Imaging ; Magnetite Nanoparticles - chemistry ; Mice ; Mice, Knockout, ApoE ; Molecular Imaging ; Nanoparticles ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - metabolism ; Plaque, Atherosclerotic - pathology ; Plaques ; Proteins ; Superparamagnetic iron oxide nanoparticle ; Target detection ; Thrombosis ; Tissue factor</subject><ispartof>Acta biomaterialia, 2019-05, Vol.90, p.324-336</ispartof><rights>2019 Acta Materialia Inc.</rights><rights>Copyright © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV May 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-3ef4bdc125a32ef405aa2a163d347b1b466a995b3ae26e2db5224bd1f27595d93</citedby><cites>FETCH-LOGICAL-c427t-3ef4bdc125a32ef405aa2a163d347b1b466a995b3ae26e2db5224bd1f27595d93</cites><orcidid>0000-0002-2815-4568 ; 0000-0001-7941-2443</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2019.04.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30954623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Qiuzhe</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Jiang, Huiwen</creatorcontrib><creatorcontrib>Du, Mengyi</creatorcontrib><creatorcontrib>Mei, Heng</creatorcontrib><creatorcontrib>Hu, Yu</creatorcontrib><title>Improved in vivo detection of atherosclerotic plaques with a tissue factor-targeting magnetic nanoprobe</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
Rupture of atherosclerotic plaques causes acute cardiovascular and cerebrovascular pathology. Tissue factor (TF) is a key factor that affects the development of atherosclerotic plaques and the formation of thrombus and thus constitutes a potential target for the detection of atherosclerotic plaques. In this study, the conjugation of the fusion protein ‘enhanced green fluorescent protein with the first epidermal growth factor domain’ (EGFP-EGF1) and superparamagnetic iron oxide nanoparticles (EGFP-EGF1-SPIONs) was explored for molecular imaging of TF-positive atherosclerotic plaques. EGFP-EGF1-SPIONs showed improved accuracy, superior contrast effects, and better cytocompatibility compared with common contrast agents in the detection of atherosclerotic plaques of apolipoprotein E knockout (ApoE−/−) mice using magnetic resonance imaging. In conclusion, EGFP-EGF1-SPION is a promising TF-targeting nanoprobe to precisely and specifically detect atherosclerotic plaques, which may improve molecular imaging diagnosis of cardiovascular and cerebrovascular events for the comprehensive evaluation of atherosclerosis.
Traditional methods can only display the status of atherosclerosis, but not forecast the progress of lesions efficiently. It remains challenging to evaluate the plaques specifically and sensitively. In this study, we constructed a tissue factor-targeted magnetic nanoprobe to specifically detect plaques by magnetic resonance imaging in vivo, which will improve the diagnostic technology for atherosclerotic plaques and offer molecular level guidance to treat atherosclerosis. Furthermore, this strategy has critical clinical significance on prevention, diagnosis and therapeutic evaluation of cardio-cerebral vascular events.</description><subject>Animals</subject><subject>Apolipoprotein E</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Atherosclerosis - metabolism</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerotic plaque</subject><subject>Biocompatibility</subject><subject>Centenarians</subject><subject>Conjugation</subject><subject>Contrast agents</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Contrast Media - pharmacology</subject><subject>Drug Delivery Systems</subject><subject>EGFP-EGF1</subject><subject>Epidermal growth factor</subject><subject>Fluorescence</subject><subject>Fusion protein</subject><subject>Green fluorescent protein</subject><subject>Growth factors</subject><subject>Iron oxides</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Mice</subject><subject>Mice, Knockout, ApoE</subject><subject>Molecular Imaging</subject><subject>Nanoparticles</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Plaque, Atherosclerotic - metabolism</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Plaques</subject><subject>Proteins</subject><subject>Superparamagnetic iron oxide nanoparticle</subject><subject>Target detection</subject><subject>Thrombosis</subject><subject>Tissue factor</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuLFDEUhYMoztj6D0QCbtxUmXeqNoIMPgYG3Og6pJJbPWmqkjZJtcy_N02PLly4Se7iO_cezkHoNSU9JVS9P_TW1SmknhE69kT0hIon6JoOeui0VMPTNmvBOk0UvUIvSjkQwgfKhufoipNRCsX4NdrfrsecTuBxiPgUTgl7qOBqSBGnGdt6DzkVt7S3BoePi_25QcG_Qr3HFtdQygZ4bk5S7qrNe6gh7vFq9xHOfLQxtf0TvETPZrsUePX479CPz5--33zt7r59ub35eNc5wXTtOMxi8o4yaTlrM5HWMksV91zoiU5CKTuOcuIWmALmJ8lYE9CZaTlKP_IdenfZ266enVazhuJgWWyEtBXDGJGCaDbohr79Bz2kLcfmrlGipUlVi2iHxIVyLYeSYTbHHFabHwwl5lyEOZhLEeZchCHCNGmTvXlcvk0r-L-iP8k34MMFgJbGKUA2xQWIDnzILX_jU_j_hd9ns5xl</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Wei, Qiuzhe</creator><creator>Wang, Jing</creator><creator>Shi, Wei</creator><creator>Zhang, Bo</creator><creator>Jiang, Huiwen</creator><creator>Du, Mengyi</creator><creator>Mei, Heng</creator><creator>Hu, Yu</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2815-4568</orcidid><orcidid>https://orcid.org/0000-0001-7941-2443</orcidid></search><sort><creationdate>20190501</creationdate><title>Improved in vivo detection of atherosclerotic plaques with a tissue factor-targeting magnetic nanoprobe</title><author>Wei, Qiuzhe ; Wang, Jing ; Shi, Wei ; Zhang, Bo ; Jiang, Huiwen ; Du, Mengyi ; Mei, Heng ; Hu, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-3ef4bdc125a32ef405aa2a163d347b1b466a995b3ae26e2db5224bd1f27595d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Apolipoprotein E</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Atherosclerosis - metabolism</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerotic plaque</topic><topic>Biocompatibility</topic><topic>Centenarians</topic><topic>Conjugation</topic><topic>Contrast agents</topic><topic>Contrast Media - chemistry</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Contrast Media - pharmacology</topic><topic>Drug Delivery Systems</topic><topic>EGFP-EGF1</topic><topic>Epidermal growth factor</topic><topic>Fluorescence</topic><topic>Fusion protein</topic><topic>Green fluorescent protein</topic><topic>Growth factors</topic><topic>Iron oxides</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Mice</topic><topic>Mice, Knockout, ApoE</topic><topic>Molecular Imaging</topic><topic>Nanoparticles</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Plaque, Atherosclerotic - metabolism</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Plaques</topic><topic>Proteins</topic><topic>Superparamagnetic iron oxide nanoparticle</topic><topic>Target detection</topic><topic>Thrombosis</topic><topic>Tissue factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Qiuzhe</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Jiang, Huiwen</creatorcontrib><creatorcontrib>Du, Mengyi</creatorcontrib><creatorcontrib>Mei, Heng</creatorcontrib><creatorcontrib>Hu, Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Qiuzhe</au><au>Wang, Jing</au><au>Shi, Wei</au><au>Zhang, Bo</au><au>Jiang, Huiwen</au><au>Du, Mengyi</au><au>Mei, Heng</au><au>Hu, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved in vivo detection of atherosclerotic plaques with a tissue factor-targeting magnetic nanoprobe</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>90</volume><spage>324</spage><epage>336</epage><pages>324-336</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
Rupture of atherosclerotic plaques causes acute cardiovascular and cerebrovascular pathology. Tissue factor (TF) is a key factor that affects the development of atherosclerotic plaques and the formation of thrombus and thus constitutes a potential target for the detection of atherosclerotic plaques. In this study, the conjugation of the fusion protein ‘enhanced green fluorescent protein with the first epidermal growth factor domain’ (EGFP-EGF1) and superparamagnetic iron oxide nanoparticles (EGFP-EGF1-SPIONs) was explored for molecular imaging of TF-positive atherosclerotic plaques. EGFP-EGF1-SPIONs showed improved accuracy, superior contrast effects, and better cytocompatibility compared with common contrast agents in the detection of atherosclerotic plaques of apolipoprotein E knockout (ApoE−/−) mice using magnetic resonance imaging. In conclusion, EGFP-EGF1-SPION is a promising TF-targeting nanoprobe to precisely and specifically detect atherosclerotic plaques, which may improve molecular imaging diagnosis of cardiovascular and cerebrovascular events for the comprehensive evaluation of atherosclerosis.
Traditional methods can only display the status of atherosclerosis, but not forecast the progress of lesions efficiently. It remains challenging to evaluate the plaques specifically and sensitively. In this study, we constructed a tissue factor-targeted magnetic nanoprobe to specifically detect plaques by magnetic resonance imaging in vivo, which will improve the diagnostic technology for atherosclerotic plaques and offer molecular level guidance to treat atherosclerosis. Furthermore, this strategy has critical clinical significance on prevention, diagnosis and therapeutic evaluation of cardio-cerebral vascular events.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30954623</pmid><doi>10.1016/j.actbio.2019.04.014</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2815-4568</orcidid><orcidid>https://orcid.org/0000-0001-7941-2443</orcidid></addata></record> |
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| subjects | Animals Apolipoprotein E Arteriosclerosis Atherosclerosis Atherosclerosis - diagnostic imaging Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerotic plaque Biocompatibility Centenarians Conjugation Contrast agents Contrast Media - chemistry Contrast Media - pharmacokinetics Contrast Media - pharmacology Drug Delivery Systems EGFP-EGF1 Epidermal growth factor Fluorescence Fusion protein Green fluorescent protein Growth factors Iron oxides Magnetic Resonance Imaging Magnetite Nanoparticles - chemistry Mice Mice, Knockout, ApoE Molecular Imaging Nanoparticles Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Plaques Proteins Superparamagnetic iron oxide nanoparticle Target detection Thrombosis Tissue factor |
| title | Improved in vivo detection of atherosclerotic plaques with a tissue factor-targeting magnetic nanoprobe |
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