Frameshift PQBP-1 mutants K192Sfs7 and R153Sfs41 implicated in X-linked intellectual disability form stable dimers

[Display omitted] •Both PQBP-1 frameshift mutants are dimeric, more compact and more stable.•ab initio bead models showed overall flat shapes, probably parallel arrangement.•Ensemble models suggested folded core (WW domain) with the rest as unfolded regions.•The interactions with an RNA pol II-deriv...

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Veröffentlicht in:	Journal of structural biology 2019-06, Vol.206 (3), p.305-313
Hauptverfasser:	Rahman, Shah Kamranur, Okazawa, Hitoshi, Chen, Yu Wai
Format:	Artikel
Sprache:	eng
Schlagworte:	Dimerisation Intrinsically disordered protein Natively unfolded Renpenning syndrome SAXS
Online-Zugang:	Volltext
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