Hexahistidine-metal assemblies: A promising drug delivery system

[Display omitted] It is of considerable interest to construct an ideal drug delivery system (i.e., high drug payload, minimal cytotoxicity, rapid endocytosis, and lysosomal escape) under mild conditions for disease treatment, tissue engineering, bioimaging, etc. Inspired by the coordinative interact...

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Veröffentlicht in:	Acta biomaterialia 2019-05, Vol.90, p.441-452
Hauptverfasser:	Huang, Wenjuan, Hao, Pengyan, Qin, Jianghui, Luo, Shan, Zhang, Tinghong, Peng, Bo, Chen, Hao, Zan, Xingjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biocompatibility Camptothecin Camptothecin - chemistry Camptothecin - pharmacokinetics Camptothecin - pharmacology Coordination Complexes - chemistry Coordination Complexes - pharmacokinetics Coordination Complexes - pharmacology Coordination polymer Cytotoxicity Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology Drug delivery Drug delivery systems Endocytosis HeLa Cells Hexahistidine Histidine Histidine - chemistry Histidine - pharmacokinetics Histidine - pharmacology Humans Internalization Lysosomes Lysosomes - metabolism Lysosomes - pathology Medical imaging Medical treatment Metal ions Metals Nanomedicine Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Responsive release Tissue engineering Toxicity
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