Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain

•Vitamin D deficiency induces dysbiosis and alterations of endocannabinoidome members.•Vitamin D deficiency induces chronic pain and spinal electrophysiological changes.•PEA counteracts behavioral and biochemical changes, whilst affecting gut microbiota. Recent evidence points to the gut microbiota...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2020-03, Vol.85, p.128-141
Hauptverfasser:	Guida, Francesca, Boccella, Serena, Belardo, Carmela, Iannotta, Monica, Piscitelli, Fabiana, De Filippis, Francesca, Paino, Salvatore, Ricciardi, Flavia, Siniscalco, Dario, Marabese, Ida, Luongo, Livio, Ercolini, Danilo, Di Marzo, Vincenzo, Maione, Sabatino
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic Pain Endocannabinoids Gastrointestinal Microbiome Gut microbiota Inflammation Mice Pain Vitamin D deficiency Vitamin D Deficiency - complications
Online-Zugang:	Volltext
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