Novel contamination-free wet milling technique using ice beads for poorly water-soluble compounds

[Display omitted] The aim of this study is to establish a contamination-free milling method using ice beads instead of conventional hard beads such as metal or ceramics. Ice beads, which melt after the milling process to form water, would solve the contamination issue attributed to bead breakage or...

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Veröffentlicht in:	International journal of pharmaceutics 2019-05, Vol.563, p.413-425
Hauptverfasser:	Funahashi, Isao, Kondo, Keita, Ito, Yu, Yamada, Mina, Niwa, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Beads mill Contamination-free Dry nanosuspension Ice beads Nanomilling Spray dry
Online-Zugang:	Volltext
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