Site-Specific Reversible Protein and Peptide Modification: Transglutaminase-Catalyzed Glutamine Conjugation and Bioorthogonal Light-Mediated Removal

Dynamic photoswitches in proteins that impart spatial and temporal control are important to manipulate and study biotic and abiotic processes. Nonetheless, approaches to install these switches into proteins site-specifically are limited. Herein we describe a novel site-specific method to generate ph...

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Veröffentlicht in:	Bioconjugate chemistry 2019-06, Vol.30 (6), p.1617-1621
Hauptverfasser:	Moulton, Kevin R, Sadiki, Amissi, Koleva, Bilyana N, Ombelets, Lincoln J, Tran, Tina H, Liu, Shanshan, Wang, Bryan, Chen, Hongyan, Micheloni, Emily, Beuning, Penny J, O’Doherty, George A, Zhou, Zhaohui Sunny
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocatalysis Casein Chromophores Coloring Agents - chemistry Conjugation E coli Gliadin Glutamine Glutamine - chemistry Humans Light Models, Molecular Nitrobenzenes - chemistry Peptides Peptides - chemistry Photolysis Proteins Proteins - chemistry Switches Transglutaminase 2 Transglutaminases - chemistry
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