The granulopoietic cytokine granulocyte colony-stimulating factor (G-CSF) induces pain: analgesia by rutin

Rutin is a glycone form of the flavonol quercetin and it reduces inflammatory pain in animal models. Therapy with granulocyte colony-stimulating factor (G-CSF) is known by the pain caused as its main side effect. The effect of rutin and its mechanisms of action were evaluated in a model of hyperalge...

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Veröffentlicht in:	Inflammopharmacology 2019-12, Vol.27 (6), p.1285-1296
Hauptverfasser:	Carvalho, Thacyana T., Mizokami, Sandra S., Ferraz, Camila R., Manchope, Marília F., Borghi, Sergio M., Fattori, Victor, Calixto-Campos, Cassia, Camilios-Neto, Doumit, Casagrande, Rubia, Verri, Waldiceu A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Analgesics - pharmacology Animals Biomedical and Life Sciences Biomedicine Cyclic GMP - physiology Cyclic GMP-Dependent Protein Kinases - physiology Cytokines - biosynthesis Dermatology Gastroenterology Granulocyte Colony-Stimulating Factor - pharmacology Heme Oxygenase-1 - physiology Hyperalgesia - drug therapy Immunology KATP Channels - physiology Male Mice Neutrophils - drug effects NF-E2-Related Factor 2 - physiology NF-kappa B - antagonists & inhibitors Nitric Oxide - physiology Original Article Pain - chemically induced Pain - drug therapy Pharmacology/Toxicology Rheumatology Rutin - pharmacology Signal Transduction - drug effects
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