Enantioselective Catalytic Asymmetric A3 Coupling with Phosphino-Imidazoline Ligands

Enantioselective Catalytic Asymmetric A3 Coupling with Phosphino-Imidazoline Ligands

A practical application of the UCD-PHIM ligand in the copper-catalyzed asymmetric A3 coupling is reported for aromatic, alkenylic, and alkynylic aldehydes under mild reaction conditions, low catalytic loading, and at ambient temperature. A broad range of aldehydes, secondary amines with a cheaper et...

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Veröffentlicht in:Journal of organic chemistry 2019-05, Vol.84 (9), p.5763-5772
Hauptverfasser: Rokade, Balaji V, Guiry, Patrick J
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description A practical application of the UCD-PHIM ligand in the copper-catalyzed asymmetric A3 coupling is reported for aromatic, alkenylic, and alkynylic aldehydes under mild reaction conditions, low catalytic loading, and at ambient temperature. A broad range of aldehydes, secondary amines with a cheaper ethyne equivalent, 2-methyl-3-butyn-2-ol, was explored and enantioselectivities of up to 99% ee were obtained. The importance of (i) axial chirality and central chirality, (ii) imidazoline moiety over oxazoline moiety, and (iii) phosphine unit is investigated for A3 coupling by synthesizing and testing a series of related ligands to UCD-PHIM.
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title Enantioselective Catalytic Asymmetric A3 Coupling with Phosphino-Imidazoline Ligands
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