Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses

Interleukin-17A (IL17A) plays a critical role in the development of numerous autoimmune diseases, including psoriasis. The clinical success of IL17A neutralizing biologics in psoriasis has underlined its importance as a drug discovery target. While many studies have focused on the differentiation an...

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Veröffentlicht in:	ACS chemical biology 2019-05, Vol.14 (5), p.857-872
Hauptverfasser:	Slivka, Peter F, Hsieh, Chen-Lin, Lipovsky, Alex, Pratt, Steven D, Locklear, John, Namovic, Marian T, McDonald, Heath A, Wetter, Joseph, Edelmayer, Rebecca, Hu, Min, Murphy, Erin, Domanus, Marc, Lu, Charles, Duggan, Ryan, King, Jacob, Scott, Victoria E, Donnelly-Roberts, Diana, Slavin, Anthony, Gopalakrishnan, Sujatha, Chung, Namjin, Goedken, Eric R
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Cells, Cultured Clustered Regularly Interspaced Short Palindromic Repeats Gene Knockdown Techniques Homeostasis Humans Inflammation - metabolism Interleukin-17 - metabolism Keratinocytes - cytology Keratinocytes - metabolism RNA, Small Interfering - genetics Signal Transduction Small Molecule Libraries - metabolism Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Tumor Necrosis Factor-alpha - metabolism
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