Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis
Background Esophageal spindle cell carcinoma (ESpCC) is a malignant tumor composed of sarcomatous components. ESpCC is treated as a squamous cell carcinoma. However, because ESpCC is a rare tumor, little is known regarding its prognosis. This study aimed to analyze patients with ESpCC who were surgi...
Gespeichert in:
| Veröffentlicht in: | Esophagus : official journal of the Japan Esophageal Society 2019-07, Vol.16 (3), p.292-299 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 299 |
|---|---|
| container_issue | 3 |
| container_start_page | 292 |
| container_title | Esophagus : official journal of the Japan Esophageal Society |
| container_volume | 16 |
| creator | Hashimoto, Masashi Kitagami, Hidehiko Niwa, Hiroki Kikkawa, Tomohiro Ohuchi, Tomoyuki Takenouchi, Toshinao Hosokawa, Masao |
| description | Background
Esophageal spindle cell carcinoma (ESpCC) is a malignant tumor composed of sarcomatous components. ESpCC is treated as a squamous cell carcinoma. However, because ESpCC is a rare tumor, little is known regarding its prognosis. This study aimed to analyze patients with ESpCC who were surgically treated at our hospital, determine the validity of surgery, and identify factors that indicate a prognosis.
Methods
Treatment characteristics, overall survival (OS), and recurrence-free survival (RFS) of 28 patients with ESpCC who underwent surgery at our hospital between 1990 and 2016 were assessed. Furthermore, factors associated with OS and RFS were analyzed.
Results
Subtotal esophagectomy with 3-field lymph node dissection and lower esophagectomy with 2-field lymph node dissection were performed in 25 and 3 patients, respectively. Chemotherapy was administered as preoperative therapy to two patients. Postoperative therapy, comprising radiotherapy and chemotherapy, was administered to three and nine patients, respectively. The 3- and 5-year RFS were 66.4% and 61.6% and the 3- and 5-year OS were 73% and 61.9%, respectively. Macroscopic type was identified as a prognostic factor. In terms of OS, prognosis was significantly worse in ulcerative-type ESpCC than in the polypoid type.
Conclusion
The 5-year OS of ESpCC mainly treated with surgical therapy was 61.9%. However, prognosis was poor in some patients with ulcerative-type ESpCC according to macroscopic type. In the future, it will be necessary to accumulate more cases and investigate therapeutic strategies added to surgery to improve prognosis. |
| doi_str_mv | 10.1007/s10388-019-00667-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2202205730</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2202205730</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-af1c3e3e0e13e16f3356712a791caccf6fb951a872285f065b13b00aa26c83493</originalsourceid><addsrcrecordid>eNp9kc2KFTEQhYMozo--gAsJuHHTWkluJ93uZFBHGHAW4zqkcyvXDN1Jm6SFfoZ5aTP2eAUXA4H8faeqDoeQVwzeMQD1PjMQXdcA6xsAKVWzPiGnTDLe9CDV0-O57U_IWc63AILvOvGcnAjohWrV7pTcXad4CDH7TE3Y03m7FW-pM7bElGl0FHOcf5gDmpHm2Yf9iNTiOFJrkvUhToaWhKbgng7rEa7qaf1ADU1YUsxzffC_kGYfDiM2PtQmZSk-htrYjGud4AV55syY8eXDfk6-f_50c3HZXH378vXi41Vjdz0vjXHMChQIyAQy6YRopWLcqJ5ZY62TbuhbZjrFedc6kO3AxABgDJe2E7tenJO3W93q9ueCuejJ53tDJmBcsuYc6mqVgIq--Q-9jUuq81aqDqO4lEJUim-UrUZzQqfn5CeTVs1A30elt6h0jUr_iUqvVfT6ofQyTLg_Sv5mUwGxAbl-hQOmf70fKfsbxYCihg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2492726633</pqid></control><display><type>article</type><title>Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hashimoto, Masashi ; Kitagami, Hidehiko ; Niwa, Hiroki ; Kikkawa, Tomohiro ; Ohuchi, Tomoyuki ; Takenouchi, Toshinao ; Hosokawa, Masao</creator><creatorcontrib>Hashimoto, Masashi ; Kitagami, Hidehiko ; Niwa, Hiroki ; Kikkawa, Tomohiro ; Ohuchi, Tomoyuki ; Takenouchi, Toshinao ; Hosokawa, Masao</creatorcontrib><description>Background
Esophageal spindle cell carcinoma (ESpCC) is a malignant tumor composed of sarcomatous components. ESpCC is treated as a squamous cell carcinoma. However, because ESpCC is a rare tumor, little is known regarding its prognosis. This study aimed to analyze patients with ESpCC who were surgically treated at our hospital, determine the validity of surgery, and identify factors that indicate a prognosis.
Methods
Treatment characteristics, overall survival (OS), and recurrence-free survival (RFS) of 28 patients with ESpCC who underwent surgery at our hospital between 1990 and 2016 were assessed. Furthermore, factors associated with OS and RFS were analyzed.
Results
Subtotal esophagectomy with 3-field lymph node dissection and lower esophagectomy with 2-field lymph node dissection were performed in 25 and 3 patients, respectively. Chemotherapy was administered as preoperative therapy to two patients. Postoperative therapy, comprising radiotherapy and chemotherapy, was administered to three and nine patients, respectively. The 3- and 5-year RFS were 66.4% and 61.6% and the 3- and 5-year OS were 73% and 61.9%, respectively. Macroscopic type was identified as a prognostic factor. In terms of OS, prognosis was significantly worse in ulcerative-type ESpCC than in the polypoid type.
Conclusion
The 5-year OS of ESpCC mainly treated with surgical therapy was 61.9%. However, prognosis was poor in some patients with ulcerative-type ESpCC according to macroscopic type. In the future, it will be necessary to accumulate more cases and investigate therapeutic strategies added to surgery to improve prognosis.</description><identifier>ISSN: 1612-9059</identifier><identifier>EISSN: 1612-9067</identifier><identifier>DOI: 10.1007/s10388-019-00667-y</identifier><identifier>PMID: 30937574</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Aged ; Carcinosarcoma - pathology ; Chemotherapy ; Combined Modality Therapy - methods ; Disease-Free Survival ; Drug Therapy - methods ; Esophageal cancer ; Esophageal Neoplasms - pathology ; Esophageal Squamous Cell Carcinoma - drug therapy ; Esophageal Squamous Cell Carcinoma - mortality ; Esophageal Squamous Cell Carcinoma - radiotherapy ; Esophageal Squamous Cell Carcinoma - surgery ; Esophagectomy - methods ; Esophagectomy - trends ; Esophagus ; Female ; Gastroenterology ; Gastrointestinal surgery ; Humans ; Japan - epidemiology ; Lymph Node Excision - methods ; Lymphatic system ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Prognosis ; Radiation therapy ; Radiotherapy - methods ; Retrospective Studies ; Sarcoma - pathology ; Surgery ; Surgical Oncology ; Thoracic Surgery ; Throat surgery</subject><ispartof>Esophagus : official journal of the Japan Esophageal Society, 2019-07, Vol.16 (3), p.292-299</ispartof><rights>The Japan Esophageal Society and Springer 2019</rights><rights>The Japan Esophageal Society and Springer 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-af1c3e3e0e13e16f3356712a791caccf6fb951a872285f065b13b00aa26c83493</citedby><cites>FETCH-LOGICAL-c492t-af1c3e3e0e13e16f3356712a791caccf6fb951a872285f065b13b00aa26c83493</cites><orcidid>0000-0002-0329-5110</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10388-019-00667-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10388-019-00667-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30937574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashimoto, Masashi</creatorcontrib><creatorcontrib>Kitagami, Hidehiko</creatorcontrib><creatorcontrib>Niwa, Hiroki</creatorcontrib><creatorcontrib>Kikkawa, Tomohiro</creatorcontrib><creatorcontrib>Ohuchi, Tomoyuki</creatorcontrib><creatorcontrib>Takenouchi, Toshinao</creatorcontrib><creatorcontrib>Hosokawa, Masao</creatorcontrib><title>Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis</title><title>Esophagus : official journal of the Japan Esophageal Society</title><addtitle>Esophagus</addtitle><addtitle>Esophagus</addtitle><description>Background
Esophageal spindle cell carcinoma (ESpCC) is a malignant tumor composed of sarcomatous components. ESpCC is treated as a squamous cell carcinoma. However, because ESpCC is a rare tumor, little is known regarding its prognosis. This study aimed to analyze patients with ESpCC who were surgically treated at our hospital, determine the validity of surgery, and identify factors that indicate a prognosis.
Methods
Treatment characteristics, overall survival (OS), and recurrence-free survival (RFS) of 28 patients with ESpCC who underwent surgery at our hospital between 1990 and 2016 were assessed. Furthermore, factors associated with OS and RFS were analyzed.
Results
Subtotal esophagectomy with 3-field lymph node dissection and lower esophagectomy with 2-field lymph node dissection were performed in 25 and 3 patients, respectively. Chemotherapy was administered as preoperative therapy to two patients. Postoperative therapy, comprising radiotherapy and chemotherapy, was administered to three and nine patients, respectively. The 3- and 5-year RFS were 66.4% and 61.6% and the 3- and 5-year OS were 73% and 61.9%, respectively. Macroscopic type was identified as a prognostic factor. In terms of OS, prognosis was significantly worse in ulcerative-type ESpCC than in the polypoid type.
Conclusion
The 5-year OS of ESpCC mainly treated with surgical therapy was 61.9%. However, prognosis was poor in some patients with ulcerative-type ESpCC according to macroscopic type. In the future, it will be necessary to accumulate more cases and investigate therapeutic strategies added to surgery to improve prognosis.</description><subject>Aged</subject><subject>Carcinosarcoma - pathology</subject><subject>Chemotherapy</subject><subject>Combined Modality Therapy - methods</subject><subject>Disease-Free Survival</subject><subject>Drug Therapy - methods</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Squamous Cell Carcinoma - drug therapy</subject><subject>Esophageal Squamous Cell Carcinoma - mortality</subject><subject>Esophageal Squamous Cell Carcinoma - radiotherapy</subject><subject>Esophageal Squamous Cell Carcinoma - surgery</subject><subject>Esophagectomy - methods</subject><subject>Esophagectomy - trends</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Lymph Node Excision - methods</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Radiotherapy - methods</subject><subject>Retrospective Studies</subject><subject>Sarcoma - pathology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Thoracic Surgery</subject><subject>Throat surgery</subject><issn>1612-9059</issn><issn>1612-9067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc2KFTEQhYMozo--gAsJuHHTWkluJ93uZFBHGHAW4zqkcyvXDN1Jm6SFfoZ5aTP2eAUXA4H8faeqDoeQVwzeMQD1PjMQXdcA6xsAKVWzPiGnTDLe9CDV0-O57U_IWc63AILvOvGcnAjohWrV7pTcXad4CDH7TE3Y03m7FW-pM7bElGl0FHOcf5gDmpHm2Yf9iNTiOFJrkvUhToaWhKbgng7rEa7qaf1ADU1YUsxzffC_kGYfDiM2PtQmZSk-htrYjGud4AV55syY8eXDfk6-f_50c3HZXH378vXi41Vjdz0vjXHMChQIyAQy6YRopWLcqJ5ZY62TbuhbZjrFedc6kO3AxABgDJe2E7tenJO3W93q9ueCuejJ53tDJmBcsuYc6mqVgIq--Q-9jUuq81aqDqO4lEJUim-UrUZzQqfn5CeTVs1A30elt6h0jUr_iUqvVfT6ofQyTLg_Sv5mUwGxAbl-hQOmf70fKfsbxYCihg</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Hashimoto, Masashi</creator><creator>Kitagami, Hidehiko</creator><creator>Niwa, Hiroki</creator><creator>Kikkawa, Tomohiro</creator><creator>Ohuchi, Tomoyuki</creator><creator>Takenouchi, Toshinao</creator><creator>Hosokawa, Masao</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0329-5110</orcidid></search><sort><creationdate>20190701</creationdate><title>Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis</title><author>Hashimoto, Masashi ; Kitagami, Hidehiko ; Niwa, Hiroki ; Kikkawa, Tomohiro ; Ohuchi, Tomoyuki ; Takenouchi, Toshinao ; Hosokawa, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-af1c3e3e0e13e16f3356712a791caccf6fb951a872285f065b13b00aa26c83493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Carcinosarcoma - pathology</topic><topic>Chemotherapy</topic><topic>Combined Modality Therapy - methods</topic><topic>Disease-Free Survival</topic><topic>Drug Therapy - methods</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Squamous Cell Carcinoma - drug therapy</topic><topic>Esophageal Squamous Cell Carcinoma - mortality</topic><topic>Esophageal Squamous Cell Carcinoma - radiotherapy</topic><topic>Esophageal Squamous Cell Carcinoma - surgery</topic><topic>Esophagectomy - methods</topic><topic>Esophagectomy - trends</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Lymph Node Excision - methods</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Radiotherapy - methods</topic><topic>Retrospective Studies</topic><topic>Sarcoma - pathology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Thoracic Surgery</topic><topic>Throat surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashimoto, Masashi</creatorcontrib><creatorcontrib>Kitagami, Hidehiko</creatorcontrib><creatorcontrib>Niwa, Hiroki</creatorcontrib><creatorcontrib>Kikkawa, Tomohiro</creatorcontrib><creatorcontrib>Ohuchi, Tomoyuki</creatorcontrib><creatorcontrib>Takenouchi, Toshinao</creatorcontrib><creatorcontrib>Hosokawa, Masao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Esophagus : official journal of the Japan Esophageal Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashimoto, Masashi</au><au>Kitagami, Hidehiko</au><au>Niwa, Hiroki</au><au>Kikkawa, Tomohiro</au><au>Ohuchi, Tomoyuki</au><au>Takenouchi, Toshinao</au><au>Hosokawa, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis</atitle><jtitle>Esophagus : official journal of the Japan Esophageal Society</jtitle><stitle>Esophagus</stitle><addtitle>Esophagus</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>16</volume><issue>3</issue><spage>292</spage><epage>299</epage><pages>292-299</pages><issn>1612-9059</issn><eissn>1612-9067</eissn><abstract>Background
Esophageal spindle cell carcinoma (ESpCC) is a malignant tumor composed of sarcomatous components. ESpCC is treated as a squamous cell carcinoma. However, because ESpCC is a rare tumor, little is known regarding its prognosis. This study aimed to analyze patients with ESpCC who were surgically treated at our hospital, determine the validity of surgery, and identify factors that indicate a prognosis.
Methods
Treatment characteristics, overall survival (OS), and recurrence-free survival (RFS) of 28 patients with ESpCC who underwent surgery at our hospital between 1990 and 2016 were assessed. Furthermore, factors associated with OS and RFS were analyzed.
Results
Subtotal esophagectomy with 3-field lymph node dissection and lower esophagectomy with 2-field lymph node dissection were performed in 25 and 3 patients, respectively. Chemotherapy was administered as preoperative therapy to two patients. Postoperative therapy, comprising radiotherapy and chemotherapy, was administered to three and nine patients, respectively. The 3- and 5-year RFS were 66.4% and 61.6% and the 3- and 5-year OS were 73% and 61.9%, respectively. Macroscopic type was identified as a prognostic factor. In terms of OS, prognosis was significantly worse in ulcerative-type ESpCC than in the polypoid type.
Conclusion
The 5-year OS of ESpCC mainly treated with surgical therapy was 61.9%. However, prognosis was poor in some patients with ulcerative-type ESpCC according to macroscopic type. In the future, it will be necessary to accumulate more cases and investigate therapeutic strategies added to surgery to improve prognosis.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>30937574</pmid><doi>10.1007/s10388-019-00667-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0329-5110</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1612-9059 |
| ispartof | Esophagus : official journal of the Japan Esophageal Society, 2019-07, Vol.16 (3), p.292-299 |
| issn | 1612-9059 1612-9067 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2202205730 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Carcinosarcoma - pathology Chemotherapy Combined Modality Therapy - methods Disease-Free Survival Drug Therapy - methods Esophageal cancer Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - drug therapy Esophageal Squamous Cell Carcinoma - mortality Esophageal Squamous Cell Carcinoma - radiotherapy Esophageal Squamous Cell Carcinoma - surgery Esophagectomy - methods Esophagectomy - trends Esophagus Female Gastroenterology Gastrointestinal surgery Humans Japan - epidemiology Lymph Node Excision - methods Lymphatic system Male Medical prognosis Medicine Medicine & Public Health Middle Aged Original Article Prognosis Radiation therapy Radiotherapy - methods Retrospective Studies Sarcoma - pathology Surgery Surgical Oncology Thoracic Surgery Throat surgery |
| title | Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A52%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognosis%20and%20prognostic%20factors%20of%20esophageal%20spindle%20cell%20carcinoma%20treated%20by%20esophagectomy:%20a%20retrospective%20single-institution%20analysis&rft.jtitle=Esophagus%20:%20official%20journal%20of%20the%20Japan%20Esophageal%20Society&rft.au=Hashimoto,%20Masashi&rft.date=2019-07-01&rft.volume=16&rft.issue=3&rft.spage=292&rft.epage=299&rft.pages=292-299&rft.issn=1612-9059&rft.eissn=1612-9067&rft_id=info:doi/10.1007/s10388-019-00667-y&rft_dat=%3Cproquest_cross%3E2202205730%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2492726633&rft_id=info:pmid/30937574&rfr_iscdi=true |