Effect of spinal manipulative therapy on mechanical pain sensitivity in patients with chronic nonspecific low back pain: a pilot randomized, controlled trial
Objectives: The long-term goal of our study is to improve the understanding of the biological mechanisms associated with spinal manipulative therapy (SMT) in low back pain. Methods: This project involved a pilot randomized, blinded clinical trial (ClinicalTrials.gov registration number NCT03078114)...
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| Veröffentlicht in: | The Journal of manual & manipulative therapy 2020-01, Vol.28 (1), p.15-27 |
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| creator | Bond, Bryan M. Kinslow, Chris D. Yoder, Adam W. Liu, Wen |
| description | Objectives: The long-term goal of our study is to improve the understanding of the biological mechanisms associated with spinal manipulative therapy (SMT) in low back pain.
Methods: This project involved a pilot randomized, blinded clinical trial (ClinicalTrials.gov registration number NCT03078114) of 3-week SMT in chronic nonspecific low back pain (CNSLBP) patients. We recruited 29 participants and randomly assigned them into either a SMT (n = 14) or sham SMT (n = 15) group. Pre- and postintervention, we quantified the effect of SMT on clinical outcomes (Numeric Pain Rating Scale and Oswestry Disability Index) and pressure pain threshold (PPT) at local (lumbar spine), regional (lower extremity), and remote (upper extremity) anatomical sites.
Results: We observed a significant main effect for time signifying reduced hypersensitivity (increased PPT) at local (p = .015) and regional (p = .014) locations at 3 weeks. Furthermore, we found significant main effects of time indicating improvements in pain (p |
| doi_str_mv | 10.1080/10669817.2019.1572986 |
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Methods: This project involved a pilot randomized, blinded clinical trial (ClinicalTrials.gov registration number NCT03078114) of 3-week SMT in chronic nonspecific low back pain (CNSLBP) patients. We recruited 29 participants and randomly assigned them into either a SMT (n = 14) or sham SMT (n = 15) group. Pre- and postintervention, we quantified the effect of SMT on clinical outcomes (Numeric Pain Rating Scale and Oswestry Disability Index) and pressure pain threshold (PPT) at local (lumbar spine), regional (lower extremity), and remote (upper extremity) anatomical sites.
Results: We observed a significant main effect for time signifying reduced hypersensitivity (increased PPT) at local (p = .015) and regional (p = .014) locations at 3 weeks. Furthermore, we found significant main effects of time indicating improvements in pain (p < .001) and disability (p = .02) from baseline among all participants regardless of intervention. However, no between-group differences were observed in PPT, clinical pain, or disability between the SMT and sham SMT groups over 3 weeks.
Conclusions: After 3 weeks of SMT or sham SMT in CNSLBP patients, we found hypoalgesia at local and remote sites along with improved pain and low back-related disability.
Level of Evidence: 1b
Trial registration:
ClinicalTrials.gov identifier: NCT03078114.</description><identifier>ISSN: 1066-9817</identifier><identifier>EISSN: 2042-6186</identifier><identifier>DOI: 10.1080/10669817.2019.1572986</identifier><identifier>PMID: 30935324</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adolescent ; Adult ; chronic ; Disability Evaluation ; Female ; Humans ; low back pain ; Low Back Pain - physiopathology ; Low Back Pain - therapy ; lumbar spine ; Male ; Manipulation, Spinal - methods ; manual therapy ; Original ; Pain Measurement ; Pain Threshold - physiology ; Pilot Projects ; pressure pain threshold ; Single-Blind Method ; Spinal manipulation ; treatment outcome ; Young Adult</subject><ispartof>The Journal of manual & manipulative therapy, 2020-01, Vol.28 (1), p.15-27</ispartof><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019</rights><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-4f3a2071a296f3cbb238eac2333ca50fafeaf359db6df1c2bb19a3327485cb683</citedby><cites>FETCH-LOGICAL-c468t-4f3a2071a296f3cbb238eac2333ca50fafeaf359db6df1c2bb19a3327485cb683</cites><orcidid>0000-0003-2431-9801</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006726/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006726/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30935324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bond, Bryan M.</creatorcontrib><creatorcontrib>Kinslow, Chris D.</creatorcontrib><creatorcontrib>Yoder, Adam W.</creatorcontrib><creatorcontrib>Liu, Wen</creatorcontrib><title>Effect of spinal manipulative therapy on mechanical pain sensitivity in patients with chronic nonspecific low back pain: a pilot randomized, controlled trial</title><title>The Journal of manual & manipulative therapy</title><addtitle>J Man Manip Ther</addtitle><description>Objectives: The long-term goal of our study is to improve the understanding of the biological mechanisms associated with spinal manipulative therapy (SMT) in low back pain.
Methods: This project involved a pilot randomized, blinded clinical trial (ClinicalTrials.gov registration number NCT03078114) of 3-week SMT in chronic nonspecific low back pain (CNSLBP) patients. We recruited 29 participants and randomly assigned them into either a SMT (n = 14) or sham SMT (n = 15) group. Pre- and postintervention, we quantified the effect of SMT on clinical outcomes (Numeric Pain Rating Scale and Oswestry Disability Index) and pressure pain threshold (PPT) at local (lumbar spine), regional (lower extremity), and remote (upper extremity) anatomical sites.
Results: We observed a significant main effect for time signifying reduced hypersensitivity (increased PPT) at local (p = .015) and regional (p = .014) locations at 3 weeks. Furthermore, we found significant main effects of time indicating improvements in pain (p < .001) and disability (p = .02) from baseline among all participants regardless of intervention. However, no between-group differences were observed in PPT, clinical pain, or disability between the SMT and sham SMT groups over 3 weeks.
Conclusions: After 3 weeks of SMT or sham SMT in CNSLBP patients, we found hypoalgesia at local and remote sites along with improved pain and low back-related disability.
Level of Evidence: 1b
Trial registration:
ClinicalTrials.gov identifier: NCT03078114.</description><subject>Adolescent</subject><subject>Adult</subject><subject>chronic</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>low back pain</subject><subject>Low Back Pain - physiopathology</subject><subject>Low Back Pain - therapy</subject><subject>lumbar spine</subject><subject>Male</subject><subject>Manipulation, Spinal - methods</subject><subject>manual therapy</subject><subject>Original</subject><subject>Pain Measurement</subject><subject>Pain Threshold - physiology</subject><subject>Pilot Projects</subject><subject>pressure pain threshold</subject><subject>Single-Blind Method</subject><subject>Spinal manipulation</subject><subject>treatment outcome</subject><subject>Young Adult</subject><issn>1066-9817</issn><issn>2042-6186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2OFCEUhYnROO3oI2hYurBafqooyoXRTMafZBI3uia3KLBRCkqgp9O-y7zr0HbPRDcmJHBzv3MucBB6TsmaEkleUyLEIGm_ZoQOa9r1bJDiAVox0rJGUCkeotWBaQ7QGXqS8w9CiGyJfIzOOBl4x1m7QjeX1hpdcLQ4Ly6AxzMEt2w9FHdtcNmYBMsex4Bnoze1pSuygAs4m5BdhVzZ41ouVWBCyXjnygbrTYqVxSGGvBjtbD37uMMj6J9_5G8w4MX5WHCCMMXZ_TbTK6xjKCl6byZckgP_FD2y4LN5dtrP0bcPl18vPjVXXz5-vnh_1ehWyNK0lgMjPQU2CMv1ODIuDWjGOdfQEQvWgOXdMI1islSzcaQDcM76VnZ6FJKfo7dH32U7zmbS9SEJvFqSmyHtVQSn_u0Et1Hf47XqCRE9E9Xg5ckgxV9bk4uaXdbGewgmbrNijNTFadtWtDuiOsWck7H3YyhRh2jVXbTqEK06RVt1L_6-473qLssKvDsCLtiYZtjF5CdVYO9jsvWXtcuK_3_GLWptuNQ</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Bond, Bryan M.</creator><creator>Kinslow, Chris D.</creator><creator>Yoder, Adam W.</creator><creator>Liu, Wen</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2431-9801</orcidid></search><sort><creationdate>20200101</creationdate><title>Effect of spinal manipulative therapy on mechanical pain sensitivity in patients with chronic nonspecific low back pain: a pilot randomized, controlled trial</title><author>Bond, Bryan M. ; Kinslow, Chris D. ; Yoder, Adam W. ; Liu, Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-4f3a2071a296f3cbb238eac2333ca50fafeaf359db6df1c2bb19a3327485cb683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>chronic</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>low back pain</topic><topic>Low Back Pain - physiopathology</topic><topic>Low Back Pain - therapy</topic><topic>lumbar spine</topic><topic>Male</topic><topic>Manipulation, Spinal - methods</topic><topic>manual therapy</topic><topic>Original</topic><topic>Pain Measurement</topic><topic>Pain Threshold - physiology</topic><topic>Pilot Projects</topic><topic>pressure pain threshold</topic><topic>Single-Blind Method</topic><topic>Spinal manipulation</topic><topic>treatment outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bond, Bryan M.</creatorcontrib><creatorcontrib>Kinslow, Chris D.</creatorcontrib><creatorcontrib>Yoder, Adam W.</creatorcontrib><creatorcontrib>Liu, Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of manual & manipulative therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bond, Bryan M.</au><au>Kinslow, Chris D.</au><au>Yoder, Adam W.</au><au>Liu, Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of spinal manipulative therapy on mechanical pain sensitivity in patients with chronic nonspecific low back pain: a pilot randomized, controlled trial</atitle><jtitle>The Journal of manual & manipulative therapy</jtitle><addtitle>J Man Manip Ther</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>28</volume><issue>1</issue><spage>15</spage><epage>27</epage><pages>15-27</pages><issn>1066-9817</issn><eissn>2042-6186</eissn><abstract>Objectives: The long-term goal of our study is to improve the understanding of the biological mechanisms associated with spinal manipulative therapy (SMT) in low back pain.
Methods: This project involved a pilot randomized, blinded clinical trial (ClinicalTrials.gov registration number NCT03078114) of 3-week SMT in chronic nonspecific low back pain (CNSLBP) patients. We recruited 29 participants and randomly assigned them into either a SMT (n = 14) or sham SMT (n = 15) group. Pre- and postintervention, we quantified the effect of SMT on clinical outcomes (Numeric Pain Rating Scale and Oswestry Disability Index) and pressure pain threshold (PPT) at local (lumbar spine), regional (lower extremity), and remote (upper extremity) anatomical sites.
Results: We observed a significant main effect for time signifying reduced hypersensitivity (increased PPT) at local (p = .015) and regional (p = .014) locations at 3 weeks. Furthermore, we found significant main effects of time indicating improvements in pain (p < .001) and disability (p = .02) from baseline among all participants regardless of intervention. However, no between-group differences were observed in PPT, clinical pain, or disability between the SMT and sham SMT groups over 3 weeks.
Conclusions: After 3 weeks of SMT or sham SMT in CNSLBP patients, we found hypoalgesia at local and remote sites along with improved pain and low back-related disability.
Level of Evidence: 1b
Trial registration:
ClinicalTrials.gov identifier: NCT03078114.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>30935324</pmid><doi>10.1080/10669817.2019.1572986</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2431-9801</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult chronic Disability Evaluation Female Humans low back pain Low Back Pain - physiopathology Low Back Pain - therapy lumbar spine Male Manipulation, Spinal - methods manual therapy Original Pain Measurement Pain Threshold - physiology Pilot Projects pressure pain threshold Single-Blind Method Spinal manipulation treatment outcome Young Adult |
| title | Effect of spinal manipulative therapy on mechanical pain sensitivity in patients with chronic nonspecific low back pain: a pilot randomized, controlled trial |
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