Quantitative analysis of corneal nerve fibers in type 2 diabetics with and without diabetic peripheral neuropathy: Comparison of manual and automated assessments
•Manual and full-automated methods for the whole cohort were significantly positive correlated for CNFL, CNBD and CNFD.•Bland–Altman plots showed good agreement between the manual and fully automated analyses of CNFL and CNBD.•Both manual and automated measurements can effectively distinguish betwee...
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| Veröffentlicht in: | Diabetes research and clinical practice 2019-05, Vol.151, p.33-38 |
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| container_title | Diabetes research and clinical practice |
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| creator | Li, Qingchun Zhong, Ying Zhang, Tiansong Zhang, Ruiyun Zhang, Qi Zheng, Hangping Ji, Lijin Sun, Wanwan Zhu, Xiaoming Zhang, Shuo Liu, Xiaoxia Lu, Bin Xiong, Qian |
| description | •Manual and full-automated methods for the whole cohort were significantly positive correlated for CNFL, CNBD and CNFD.•Bland–Altman plots showed good agreement between the manual and fully automated analyses of CNFL and CNBD.•Both manual and automated measurements can effectively distinguish between subjects with and without DPN.•Fully-automated corneal nerve quantification may be a fast, objective way to detect DPN.
To examine and compare fully-automated and manually measured corneal nerve fiber parameters in type 2 diabetes mellitus (T2DM) patients with and without diabetic peripheral neuropathy (DPN).
A total of 128 T2DM subjects and 24 healthy controls underwent neuropathy assessment and bilateral corneal confocal microscopy (CCM). Five representative nerve fiber images were selected for each participant and analyzed manually and with fully-automated software. Corneal nerve fiber length (CNFL), branch density (CNBD), and fiber density (CNFD) were examined.
Manual and full-automated methods for the whole cohort were significantly positive correlated for CNFL, CNBD and CNFD (r = 0.818, 0.845, 0.457, all P |
| doi_str_mv | 10.1016/j.diabres.2019.03.039 |
| format | Article |
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To examine and compare fully-automated and manually measured corneal nerve fiber parameters in type 2 diabetes mellitus (T2DM) patients with and without diabetic peripheral neuropathy (DPN).
A total of 128 T2DM subjects and 24 healthy controls underwent neuropathy assessment and bilateral corneal confocal microscopy (CCM). Five representative nerve fiber images were selected for each participant and analyzed manually and with fully-automated software. Corneal nerve fiber length (CNFL), branch density (CNBD), and fiber density (CNFD) were examined.
Manual and full-automated methods for the whole cohort were significantly positive correlated for CNFL, CNBD and CNFD (r = 0.818, 0.845, 0.457, all P < 0.001). Analysis of agreement between the two measurements using Bland-Altman method showed a bias of 2.05 mm/mm2 (95% limits of agreement: −2.03 mm/mm2, 6.13 mm/mm2), 1.62 no./mm2 (95% limits of agreement: −17.92 no./mm2, 21.17 no./mm2), and 16.0 no./mm2 (95% limits of agreement: −0.14 no./mm2, 32.14 no./mm2) for CNFL, CNBD and CNFD respectively. A progressive decrease in manual and full-automated CNFL, CNBD and CNFD accompanied with the occurrence of DPN, The fully-automated method slightly underestimated corneal nerve fiber parameters.
This study demonstrated strong correlations between manual and fully-automated CNFL and CNBD, but not CNFD. Fully-automated corneal nerve fiber parameter quantification may be a fast, objective way to detect DPN.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2019.03.039</identifier><identifier>PMID: 30935930</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>ACCMetrics ; Corneal confocal microscopy ; Corneal nerve fiber ; Diabetic peripheral neuropathy ; Type 2 diabetes mellitus</subject><ispartof>Diabetes research and clinical practice, 2019-05, Vol.151, p.33-38</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-3155243ea7d665fd26c5a07e26a921f7f80f591a6c7922e09d817f8b19a82c9b3</citedby><cites>FETCH-LOGICAL-c365t-3155243ea7d665fd26c5a07e26a921f7f80f591a6c7922e09d817f8b19a82c9b3</cites><orcidid>0000-0003-2812-2176</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2019.03.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30935930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Qingchun</creatorcontrib><creatorcontrib>Zhong, Ying</creatorcontrib><creatorcontrib>Zhang, Tiansong</creatorcontrib><creatorcontrib>Zhang, Ruiyun</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Zheng, Hangping</creatorcontrib><creatorcontrib>Ji, Lijin</creatorcontrib><creatorcontrib>Sun, Wanwan</creatorcontrib><creatorcontrib>Zhu, Xiaoming</creatorcontrib><creatorcontrib>Zhang, Shuo</creatorcontrib><creatorcontrib>Liu, Xiaoxia</creatorcontrib><creatorcontrib>Lu, Bin</creatorcontrib><creatorcontrib>Xiong, Qian</creatorcontrib><title>Quantitative analysis of corneal nerve fibers in type 2 diabetics with and without diabetic peripheral neuropathy: Comparison of manual and automated assessments</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>•Manual and full-automated methods for the whole cohort were significantly positive correlated for CNFL, CNBD and CNFD.•Bland–Altman plots showed good agreement between the manual and fully automated analyses of CNFL and CNBD.•Both manual and automated measurements can effectively distinguish between subjects with and without DPN.•Fully-automated corneal nerve quantification may be a fast, objective way to detect DPN.
To examine and compare fully-automated and manually measured corneal nerve fiber parameters in type 2 diabetes mellitus (T2DM) patients with and without diabetic peripheral neuropathy (DPN).
A total of 128 T2DM subjects and 24 healthy controls underwent neuropathy assessment and bilateral corneal confocal microscopy (CCM). Five representative nerve fiber images were selected for each participant and analyzed manually and with fully-automated software. Corneal nerve fiber length (CNFL), branch density (CNBD), and fiber density (CNFD) were examined.
Manual and full-automated methods for the whole cohort were significantly positive correlated for CNFL, CNBD and CNFD (r = 0.818, 0.845, 0.457, all P < 0.001). Analysis of agreement between the two measurements using Bland-Altman method showed a bias of 2.05 mm/mm2 (95% limits of agreement: −2.03 mm/mm2, 6.13 mm/mm2), 1.62 no./mm2 (95% limits of agreement: −17.92 no./mm2, 21.17 no./mm2), and 16.0 no./mm2 (95% limits of agreement: −0.14 no./mm2, 32.14 no./mm2) for CNFL, CNBD and CNFD respectively. A progressive decrease in manual and full-automated CNFL, CNBD and CNFD accompanied with the occurrence of DPN, The fully-automated method slightly underestimated corneal nerve fiber parameters.
This study demonstrated strong correlations between manual and fully-automated CNFL and CNBD, but not CNFD. Fully-automated corneal nerve fiber parameter quantification may be a fast, objective way to detect DPN.</description><subject>ACCMetrics</subject><subject>Corneal confocal microscopy</subject><subject>Corneal nerve fiber</subject><subject>Diabetic peripheral neuropathy</subject><subject>Type 2 diabetes mellitus</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFUduKFDEQDaK44-onKHn0ZcZcpi_xRWTwBgsi6HOoSVczGbqTNpXeZT7HPzU9M-6rcCBF1bkQDmOvpdhIIet3x03nYZ-QNkpIsxG6wDxhK9k2at0q1Txlq8Jrz_MNe0F0FELUels9ZzdaGF0ZLVbsz48ZQvYZsr9HDgGGE3nisecupoAw8ICpXHq_x0TcB55PE3LFl3TM3hF_8PlQlN15iHN-PPEJk58OmM4uc4oT5MPpPd_FcYLkKYYlZ4QwF8JiAHOOI2QsExESjRgyvWTPehgIX13fW_br86efu6_ru-9fvu0-3q2drqu81rKq1FYjNF1dV32naleBaFDVYJTsm74VfWUk1K4xSqEwXSvLci8NtMqZvb5lby--U4q_Z6RsR08OhwECxpmsUmKBabaFWl2oLkWihL2dkh8hnawUdmnHHu21Hbu0Y4UuMEX35hox70fsHlX_6iiEDxcClo_ee0yWnMfgsPMJXbZd9P-J-Av64qcF</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Li, Qingchun</creator><creator>Zhong, Ying</creator><creator>Zhang, Tiansong</creator><creator>Zhang, Ruiyun</creator><creator>Zhang, Qi</creator><creator>Zheng, Hangping</creator><creator>Ji, Lijin</creator><creator>Sun, Wanwan</creator><creator>Zhu, Xiaoming</creator><creator>Zhang, Shuo</creator><creator>Liu, Xiaoxia</creator><creator>Lu, Bin</creator><creator>Xiong, Qian</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2812-2176</orcidid></search><sort><creationdate>20190501</creationdate><title>Quantitative analysis of corneal nerve fibers in type 2 diabetics with and without diabetic peripheral neuropathy: Comparison of manual and automated assessments</title><author>Li, Qingchun ; Zhong, Ying ; Zhang, Tiansong ; Zhang, Ruiyun ; Zhang, Qi ; Zheng, Hangping ; Ji, Lijin ; Sun, Wanwan ; Zhu, Xiaoming ; Zhang, Shuo ; Liu, Xiaoxia ; Lu, Bin ; Xiong, Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-3155243ea7d665fd26c5a07e26a921f7f80f591a6c7922e09d817f8b19a82c9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>ACCMetrics</topic><topic>Corneal confocal microscopy</topic><topic>Corneal nerve fiber</topic><topic>Diabetic peripheral neuropathy</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qingchun</creatorcontrib><creatorcontrib>Zhong, Ying</creatorcontrib><creatorcontrib>Zhang, Tiansong</creatorcontrib><creatorcontrib>Zhang, Ruiyun</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Zheng, Hangping</creatorcontrib><creatorcontrib>Ji, Lijin</creatorcontrib><creatorcontrib>Sun, Wanwan</creatorcontrib><creatorcontrib>Zhu, Xiaoming</creatorcontrib><creatorcontrib>Zhang, Shuo</creatorcontrib><creatorcontrib>Liu, Xiaoxia</creatorcontrib><creatorcontrib>Lu, Bin</creatorcontrib><creatorcontrib>Xiong, Qian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qingchun</au><au>Zhong, Ying</au><au>Zhang, Tiansong</au><au>Zhang, Ruiyun</au><au>Zhang, Qi</au><au>Zheng, Hangping</au><au>Ji, Lijin</au><au>Sun, Wanwan</au><au>Zhu, Xiaoming</au><au>Zhang, Shuo</au><au>Liu, Xiaoxia</au><au>Lu, Bin</au><au>Xiong, Qian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative analysis of corneal nerve fibers in type 2 diabetics with and without diabetic peripheral neuropathy: Comparison of manual and automated assessments</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>151</volume><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>•Manual and full-automated methods for the whole cohort were significantly positive correlated for CNFL, CNBD and CNFD.•Bland–Altman plots showed good agreement between the manual and fully automated analyses of CNFL and CNBD.•Both manual and automated measurements can effectively distinguish between subjects with and without DPN.•Fully-automated corneal nerve quantification may be a fast, objective way to detect DPN.
To examine and compare fully-automated and manually measured corneal nerve fiber parameters in type 2 diabetes mellitus (T2DM) patients with and without diabetic peripheral neuropathy (DPN).
A total of 128 T2DM subjects and 24 healthy controls underwent neuropathy assessment and bilateral corneal confocal microscopy (CCM). Five representative nerve fiber images were selected for each participant and analyzed manually and with fully-automated software. Corneal nerve fiber length (CNFL), branch density (CNBD), and fiber density (CNFD) were examined.
Manual and full-automated methods for the whole cohort were significantly positive correlated for CNFL, CNBD and CNFD (r = 0.818, 0.845, 0.457, all P < 0.001). Analysis of agreement between the two measurements using Bland-Altman method showed a bias of 2.05 mm/mm2 (95% limits of agreement: −2.03 mm/mm2, 6.13 mm/mm2), 1.62 no./mm2 (95% limits of agreement: −17.92 no./mm2, 21.17 no./mm2), and 16.0 no./mm2 (95% limits of agreement: −0.14 no./mm2, 32.14 no./mm2) for CNFL, CNBD and CNFD respectively. A progressive decrease in manual and full-automated CNFL, CNBD and CNFD accompanied with the occurrence of DPN, The fully-automated method slightly underestimated corneal nerve fiber parameters.
This study demonstrated strong correlations between manual and fully-automated CNFL and CNBD, but not CNFD. Fully-automated corneal nerve fiber parameter quantification may be a fast, objective way to detect DPN.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>30935930</pmid><doi>10.1016/j.diabres.2019.03.039</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2812-2176</orcidid></addata></record> |
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| ispartof | Diabetes research and clinical practice, 2019-05, Vol.151, p.33-38 |
| issn | 0168-8227 1872-8227 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | ACCMetrics Corneal confocal microscopy Corneal nerve fiber Diabetic peripheral neuropathy Type 2 diabetes mellitus |
| title | Quantitative analysis of corneal nerve fibers in type 2 diabetics with and without diabetic peripheral neuropathy: Comparison of manual and automated assessments |
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