The synthesis of 4,6-diaryl-2-pyridones and their bioactivation in CYP1 expressing breast cancer cells

[Display omitted] As part of a programme to develop anticancer prodrugs which are activated by cytochrome P450 (CYP)1B1, a library of 4,6-diaryl-2-pyridones was synthesised in yields of 6–60% from the corresponding chalcones. A number of these derivatives showed promising antiproliferative activitie...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2019-06, Vol.29 (11), p.1403-1406
Hauptverfasser:	Ruparelia, Ketan C., Lodhi, Sabahat, Ankrett, Dyan N., Wilsher, Nicola E., Arroo, Randolph R.J., Potter, Gerard A., Beresford, Kenneth J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	4,6-Diaryl-2-pyridones Antiproliferative Chalcones CYP1B1 Prodrug
Online-Zugang:	Volltext
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