Development of a platform for activatable fluorescent substrates of glucose transporters (GLUTs)

[Display omitted] We have developed a platform for activatable fluorescent substrates of glucose transporters (GLUTs). We firstly conjugated fluorescein to glucosamine via an amide or methylene linker at the C-2 position of d-glucosamine, but the resulting compounds, FLG1 and FLG2, showed no uptake...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2019-05, Vol.27 (10), p.2122-2126
Hauptverfasser:	Takasugi, Tomohiro, Hanaoka, Kenjiro, Sasaki, Ayako, Ikeno, Takayuki, Komatsu, Toru, Ueno, Tasuku, Yamada, Katsuya, Urano, Yasuteru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Fluorescein - chemistry Fluorescent Dyes - chemistry Fluorescent imaging Fluorescent substrates Glucosamine - analogs & derivatives Glucosamine - metabolism Glucose Glucose - analogs & derivatives Glucose - metabolism Glucose Transport Proteins, Facilitative - metabolism GLUT Mice Microscopy, Fluorescence Tumor
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