Label-free target identification in drug discovery via phenotypic screening

[Display omitted] Phenotypic screening has demonstrated its advantage in the discovery of first-in-class therapeutics, whereas target-based screening has showed strength for follower drugs. Owing to the unbiased nature of phenotypic screening, novel druggable proteins can be uncovered by target iden...

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Veröffentlicht in:	Current opinion in chemical biology 2019-06, Vol.50, p.66-72
Hauptverfasser:	Park, Hankum, Ha, Jaeyoung, Park, Seung Bum
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Discovery Electrophoresis, Gel, Two-Dimensional Oxidation-Reduction Phenotype Protein Denaturation Protein Stability Proteolysis Proteome Small Molecule Libraries Temperature
Online-Zugang:	Volltext
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