Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8 + T Cell Responses

Cytotoxic CD8 T lymphocytes (CTLs) recognize peptides displayed by HLA class I molecules on cell surfaces, monitoring pathological conditions such as cancer. Difficulty in predicting HLA class I ligands is attributed to the complexity of the Ag processing pathway across the cytosol and the endoplasm...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-05, Vol.202 (10), p.2849-2855
Hauptverfasser:	Hongo, Ayumi, Kanaseki, Takayuki, Tokita, Serina, Kochin, Vitaly, Miyamoto, Sho, Hashino, Yuiko, Codd, Amy, Kawai, Noriko, Nakatsugawa, Munehide, Hirohashi, Yoshihiko, Sato, Noriyuki, Torigoe, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Line Histocompatibility Antigens Class I - chemistry Histocompatibility Antigens Class I - immunology Humans Immunity, Cellular Peptides - chemistry Peptides - immunology Proline - chemistry Proline - immunology
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