Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension
In most cases of acute pulmonary embolism, fbrinolysis of the embolus takes place, restoring blood fow and normalizing hemodynamic parameters. However, in a minority of patients, a residual organized clot remains adherent to the pulmonary vasculature which, over time, results in a progressive increa...
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| Veröffentlicht in: | Internal and emergency medicine 2019-06, Vol.14 (4), p.495-496 |
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| creator | Cervi, Andrea Douketis, James Demetrios |
| description | In most cases of acute pulmonary embolism, fbrinolysis of the embolus takes place, restoring blood fow and normalizing hemodynamic parameters. However, in a minority of patients, a residual organized clot remains adherent to the pulmonary vasculature which, over time, results in a progressive increase in pulmonary vascular resistance. This condition, known as chronic thromboembolic pulmonary hypertension (CTEPH), is a rare complication of pulmonary embolism that is characterized by the presence of persistent and organized thrombi in the proximal pulmonary arteries [1, 2]. Poor thrombus resolution due to inadequate fbrinolysis and/or recurrent thrombosis likely predispose towards the development of CTEPH. However, why only a small subset of patients go on to develop CTEPH following acute pulmonary embolism remains uncertain. |
| doi_str_mv | 10.1007/s11739-019-02078-4 |
| format | Article |
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However, in a minority of patients, a residual organized clot remains adherent to the pulmonary vasculature which, over time, results in a progressive increase in pulmonary vascular resistance. This condition, known as chronic thromboembolic pulmonary hypertension (CTEPH), is a rare complication of pulmonary embolism that is characterized by the presence of persistent and organized thrombi in the proximal pulmonary arteries [1, 2]. Poor thrombus resolution due to inadequate fbrinolysis and/or recurrent thrombosis likely predispose towards the development of CTEPH. 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However, why only a small subset of patients go on to develop CTEPH following acute pulmonary embolism remains uncertain.</description><subject>Antibodies, Antiphospholipid</subject><subject>Anticoagulants</subject><subject>Antiphospholipid antibodies</subject><subject>Blood clots</subject><subject>Embolisms</subject><subject>Emergency medical care</subject><subject>Epidemiology</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypertension, Pulmonary</subject><subject>Im - Commentary</subject><subject>Immunoglobulins</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Pulmonary hypertension</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><issn>1828-0447</issn><issn>1970-9366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1P3DAQhq2KqsDSP9ADisSllxQ7ju34iBD9kJDKoZwtx5nsGhI72AnV_vsO7EIlDhxG47Gf-fC8hHxh9BujVJ1nxhTXJWVoFVVNWX8gR0wrWmou5QGem6opaV2rQ3Kc8x2lQkimPpFDTjVXDedH5P4mwaMdIDgoYl_YMPtpEzPa4CffPV-0sfOQCzvGsC4mO3sIcy7--nlTuE2KwbtiRj-2EdAGDKdlQNimbbHZTpBmCNnHcEI-9nbI8HnvV-T2-9Wfy5_l9e8fvy4vrkvHKznj8J0QvWw6pfqWMqe5k9QpC1oKVbEWOqEbyygGFYXKMl13Wlgrectkazlfka-7ulOKDwvk2Yw-OxgGGyAu2WBaxbQQuIEVOXuD3sUlBZzuiWK1pLpWSFU7yqWYc4LeTMmP-D3DqHmSwuykMCiFeZbC1Jh0ui-9tCN0rykvu0eA74CMT2EN6X_vd8r-A7dJlgY</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Cervi, Andrea</creator><creator>Douketis, James Demetrios</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension</title><author>Cervi, Andrea ; 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| subjects | Antibodies, Antiphospholipid Anticoagulants Antiphospholipid antibodies Blood clots Embolisms Emergency medical care Epidemiology Health risk assessment Humans Hypertension, Pulmonary Im - Commentary Immunoglobulins Internal Medicine Medicine Medicine & Public Health Prevalence Proteins Pulmonary arteries Pulmonary artery Pulmonary hypertension Studies Systematic review Thromboembolism Thrombosis |
| title | Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension |
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