Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension
In most cases of acute pulmonary embolism, fbrinolysis of the embolus takes place, restoring blood fow and normalizing hemodynamic parameters. However, in a minority of patients, a residual organized clot remains adherent to the pulmonary vasculature which, over time, results in a progressive increa...
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Veröffentlicht in: | Internal and emergency medicine 2019-06, Vol.14 (4), p.495-496 |
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description | In most cases of acute pulmonary embolism, fbrinolysis of the embolus takes place, restoring blood fow and normalizing hemodynamic parameters. However, in a minority of patients, a residual organized clot remains adherent to the pulmonary vasculature which, over time, results in a progressive increase in pulmonary vascular resistance. This condition, known as chronic thromboembolic pulmonary hypertension (CTEPH), is a rare complication of pulmonary embolism that is characterized by the presence of persistent and organized thrombi in the proximal pulmonary arteries [1, 2]. Poor thrombus resolution due to inadequate fbrinolysis and/or recurrent thrombosis likely predispose towards the development of CTEPH. However, why only a small subset of patients go on to develop CTEPH following acute pulmonary embolism remains uncertain. |
doi_str_mv | 10.1007/s11739-019-02078-4 |
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However, in a minority of patients, a residual organized clot remains adherent to the pulmonary vasculature which, over time, results in a progressive increase in pulmonary vascular resistance. This condition, known as chronic thromboembolic pulmonary hypertension (CTEPH), is a rare complication of pulmonary embolism that is characterized by the presence of persistent and organized thrombi in the proximal pulmonary arteries [1, 2]. Poor thrombus resolution due to inadequate fbrinolysis and/or recurrent thrombosis likely predispose towards the development of CTEPH. However, why only a small subset of patients go on to develop CTEPH following acute pulmonary embolism remains uncertain.</description><identifier>ISSN: 1828-0447</identifier><identifier>EISSN: 1970-9366</identifier><identifier>DOI: 10.1007/s11739-019-02078-4</identifier><identifier>PMID: 30937833</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antibodies, Antiphospholipid ; Anticoagulants ; Antiphospholipid antibodies ; Blood clots ; Embolisms ; Emergency medical care ; Epidemiology ; Health risk assessment ; Humans ; Hypertension, Pulmonary ; Im - Commentary ; Immunoglobulins ; Internal Medicine ; Medicine ; Medicine & Public Health ; Prevalence ; Proteins ; Pulmonary arteries ; Pulmonary artery ; Pulmonary hypertension ; Studies ; Systematic review ; Thromboembolism ; Thrombosis</subject><ispartof>Internal and emergency medicine, 2019-06, Vol.14 (4), p.495-496</ispartof><rights>Società Italiana di Medicina Interna (SIMI) 2019</rights><rights>Internal and Emergency Medicine is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-93d55f68d77fb01c93c60c7ae965721bed598a1057220e2a194d95aa63b16ba33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11739-019-02078-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11739-019-02078-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30937833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cervi, Andrea</creatorcontrib><creatorcontrib>Douketis, James Demetrios</creatorcontrib><title>Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension</title><title>Internal and emergency medicine</title><addtitle>Intern Emerg Med</addtitle><addtitle>Intern Emerg Med</addtitle><description>In most cases of acute pulmonary embolism, fbrinolysis of the embolus takes place, restoring blood fow and normalizing hemodynamic parameters. 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However, why only a small subset of patients go on to develop CTEPH following acute pulmonary embolism remains uncertain.</description><subject>Antibodies, Antiphospholipid</subject><subject>Anticoagulants</subject><subject>Antiphospholipid antibodies</subject><subject>Blood clots</subject><subject>Embolisms</subject><subject>Emergency medical care</subject><subject>Epidemiology</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypertension, Pulmonary</subject><subject>Im - Commentary</subject><subject>Immunoglobulins</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Pulmonary hypertension</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><issn>1828-0447</issn><issn>1970-9366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1P3DAQhq2KqsDSP9ADisSllxQ7ju34iBD9kJDKoZwtx5nsGhI72AnV_vsO7EIlDhxG47Gf-fC8hHxh9BujVJ1nxhTXJWVoFVVNWX8gR0wrWmou5QGem6opaV2rQ3Kc8x2lQkimPpFDTjVXDedH5P4mwaMdIDgoYl_YMPtpEzPa4CffPV-0sfOQCzvGsC4mO3sIcy7--nlTuE2KwbtiRj-2EdAGDKdlQNimbbHZTpBmCNnHcEI-9nbI8HnvV-T2-9Wfy5_l9e8fvy4vrkvHKznj8J0QvWw6pfqWMqe5k9QpC1oKVbEWOqEbyygGFYXKMl13Wlgrectkazlfka-7ulOKDwvk2Yw-OxgGGyAu2WBaxbQQuIEVOXuD3sUlBZzuiWK1pLpWSFU7yqWYc4LeTMmP-D3DqHmSwuykMCiFeZbC1Jh0ui-9tCN0rykvu0eA74CMT2EN6X_vd8r-A7dJlgY</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Cervi, Andrea</creator><creator>Douketis, James Demetrios</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension</title><author>Cervi, Andrea ; Douketis, James Demetrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-93d55f68d77fb01c93c60c7ae965721bed598a1057220e2a194d95aa63b16ba33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antibodies, Antiphospholipid</topic><topic>Anticoagulants</topic><topic>Antiphospholipid antibodies</topic><topic>Blood clots</topic><topic>Embolisms</topic><topic>Emergency medical care</topic><topic>Epidemiology</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypertension, Pulmonary</topic><topic>Im - Commentary</topic><topic>Immunoglobulins</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Prevalence</topic><topic>Proteins</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Pulmonary hypertension</topic><topic>Studies</topic><topic>Systematic review</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cervi, Andrea</creatorcontrib><creatorcontrib>Douketis, James Demetrios</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Internal and emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cervi, Andrea</au><au>Douketis, James Demetrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension</atitle><jtitle>Internal and emergency medicine</jtitle><stitle>Intern Emerg Med</stitle><addtitle>Intern Emerg Med</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>14</volume><issue>4</issue><spage>495</spage><epage>496</epage><pages>495-496</pages><issn>1828-0447</issn><eissn>1970-9366</eissn><abstract>In most cases of acute pulmonary embolism, fbrinolysis of the embolus takes place, restoring blood fow and normalizing hemodynamic parameters. However, in a minority of patients, a residual organized clot remains adherent to the pulmonary vasculature which, over time, results in a progressive increase in pulmonary vascular resistance. This condition, known as chronic thromboembolic pulmonary hypertension (CTEPH), is a rare complication of pulmonary embolism that is characterized by the presence of persistent and organized thrombi in the proximal pulmonary arteries [1, 2]. Poor thrombus resolution due to inadequate fbrinolysis and/or recurrent thrombosis likely predispose towards the development of CTEPH. However, why only a small subset of patients go on to develop CTEPH following acute pulmonary embolism remains uncertain.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30937833</pmid><doi>10.1007/s11739-019-02078-4</doi><tpages>2</tpages></addata></record> |
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subjects | Antibodies, Antiphospholipid Anticoagulants Antiphospholipid antibodies Blood clots Embolisms Emergency medical care Epidemiology Health risk assessment Humans Hypertension, Pulmonary Im - Commentary Immunoglobulins Internal Medicine Medicine Medicine & Public Health Prevalence Proteins Pulmonary arteries Pulmonary artery Pulmonary hypertension Studies Systematic review Thromboembolism Thrombosis |
title | Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension |
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