Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal models
Alzheimer’s disease (AD) is a devastating neurodegenerative disease affecting millions of people worldwide. AD is characterized by a profound impairment of higher cognitive functions and still lacks any effective disease-modifying treatment. Defective insulin signaling has been implicated in AD path...
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| Veröffentlicht in: | Experimental neurology 2019-06, Vol.316, p.1-11 |
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| container_title | Experimental neurology |
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| creator | Lyra e Silva, Natalia de M. Gonçalves, Rafaella Araujo Boehnke, Susan E. Forny-Germano, Leticia Munoz, Douglas P. De Felice, Fernanda G. |
| description | Alzheimer’s disease (AD) is a devastating neurodegenerative disease affecting millions of people worldwide. AD is characterized by a profound impairment of higher cognitive functions and still lacks any effective disease-modifying treatment. Defective insulin signaling has been implicated in AD pathophysiology, but the mechanisms underlying this process are not fully understood. Here, we review the molecular mechanisms underlying defective brain insulin signaling in rodent models of AD, and in a non-human primate (NHP) model of the disease that recapitulates features observed in AD brains. We further highlight similarities between the NHP and human brains and discuss why NHP models of AD are important to understand disease mechanisms and to improve the translation of effective therapies to humans. We discuss how studies using different animal models have contributed to elucidate the link between insulin resistance and AD. |
| doi_str_mv | 10.1016/j.expneurol.2019.03.016 |
| format | Article |
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AD is characterized by a profound impairment of higher cognitive functions and still lacks any effective disease-modifying treatment. Defective insulin signaling has been implicated in AD pathophysiology, but the mechanisms underlying this process are not fully understood. Here, we review the molecular mechanisms underlying defective brain insulin signaling in rodent models of AD, and in a non-human primate (NHP) model of the disease that recapitulates features observed in AD brains. We further highlight similarities between the NHP and human brains and discuss why NHP models of AD are important to understand disease mechanisms and to improve the translation of effective therapies to humans. 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AD is characterized by a profound impairment of higher cognitive functions and still lacks any effective disease-modifying treatment. Defective insulin signaling has been implicated in AD pathophysiology, but the mechanisms underlying this process are not fully understood. Here, we review the molecular mechanisms underlying defective brain insulin signaling in rodent models of AD, and in a non-human primate (NHP) model of the disease that recapitulates features observed in AD brains. We further highlight similarities between the NHP and human brains and discuss why NHP models of AD are important to understand disease mechanisms and to improve the translation of effective therapies to humans. We discuss how studies using different animal models have contributed to elucidate the link between insulin resistance and AD.</description><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer’s disease</subject><subject>Animal models</subject><subject>Animals</subject><subject>Cognitive control</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Models, Animal</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9u1DAQhy0EokvhFcBHLgljO2tvuK0qCpUqcaFnK7YnXS-Js3gSCpz6GrweT4JXW3rlNPJP3_zxx9gbAbUAod_ta_xxSLjkaagliLYGVZf8CVsJaKGSjYKnbAUgmqrZbPQZe0G0B4C2keY5O1PQqvLQK7a7SQEzzV0KMd3yeYd8iOkrdzjfISYeEy0l4BkpHimPvKB8O_zaYRwx_7n_TTxEwo7wPb9KFG93M_E-T2MB49gNfJwCDvSSPeu7gfDVQz1nN5cfvlx8qq4_f7y62F5XXhkxV86LfqOkNmGNau1k12vwEjrj12i0Mj4o1_c-hLVSLXgjXd-6xoXO6da12qlz9vY095CnbwvSbMdIHoehSzgtZGXRZYTRjSyoOaE-T0QZe3vI5eL80wqwR812bx8126NmC8qWvHS-fliyuBHDY98_rwXYnoDyc_weMVvyEYu9EDP62YYp_nfJX4gblro</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Lyra e Silva, Natalia de M.</creator><creator>Gonçalves, Rafaella Araujo</creator><creator>Boehnke, Susan E.</creator><creator>Forny-Germano, Leticia</creator><creator>Munoz, Douglas P.</creator><creator>De Felice, Fernanda G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201906</creationdate><title>Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal models</title><author>Lyra e Silva, Natalia de M. ; Gonçalves, Rafaella Araujo ; Boehnke, Susan E. ; Forny-Germano, Leticia ; Munoz, Douglas P. ; De Felice, Fernanda G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-bc1f83267d5e35b2af60c20a7c5e7637cd3bffcdd53390c72bf9b4bdab69b96b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer’s disease</topic><topic>Animal models</topic><topic>Animals</topic><topic>Cognitive control</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Models, Animal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyra e Silva, Natalia de M.</creatorcontrib><creatorcontrib>Gonçalves, Rafaella Araujo</creatorcontrib><creatorcontrib>Boehnke, Susan E.</creatorcontrib><creatorcontrib>Forny-Germano, Leticia</creatorcontrib><creatorcontrib>Munoz, Douglas P.</creatorcontrib><creatorcontrib>De Felice, Fernanda G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyra e Silva, Natalia de M.</au><au>Gonçalves, Rafaella Araujo</au><au>Boehnke, Susan E.</au><au>Forny-Germano, Leticia</au><au>Munoz, Douglas P.</au><au>De Felice, Fernanda G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal models</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2019-06</date><risdate>2019</risdate><volume>316</volume><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><abstract>Alzheimer’s disease (AD) is a devastating neurodegenerative disease affecting millions of people worldwide. 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| fulltext | fulltext |
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| ispartof | Experimental neurology, 2019-06, Vol.316, p.1-11 |
| issn | 0014-4886 1090-2430 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2201717642 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alzheimer Disease - pathology Alzheimer’s disease Animal models Animals Cognitive control Humans Inflammation Insulin Insulin Resistance Models, Animal |
| title | Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal models |
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