Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus–positive oropharyngeal squamous cell carcinoma

Background Human papillomavirus (HPV)–associated oropharyngeal cancer is a disease clinically and biologically distinct from smoking‐related head and neck squamous cell carcinoma (HNSCC). Despite its rapidly increasing incidence, the mutational landscape of HPV+ oropharyngeal squamous cell carcinoma...

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Veröffentlicht in:	Cancer 2019-07, Vol.125 (14), p.2423-2434
Hauptverfasser:	Haft, Sunny, Ren, Shuling, Xu, Guorong, Mark, Adam, Fisch, Kathleen, Guo, Theresa W., Khan, Zubair, Pang, John, Ando, Mizuo, Liu, Chao, Sakai, Akihiro, Fukusumi, Takahito, Califano, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Cancer Catalysis Chromatin Chromatin Assembly and Disassembly - genetics Class I Phosphatidylinositol 3-Kinases - genetics Cohort Studies Cyclic AMP response element-binding protein DNA helicase epigenetics Event-related potentials exome sequencing Female Fibroblast growth factor receptor 3 Fibroblast growth factor receptors Gene expression Gene regulation Gene sequencing Genes Genomes Growth factors Head & neck cancer head and neck squamous cell carcinoma Human papillomavirus human papillomavirus (HPV) Human papillomavirus 16 - immunology Humans Kinases Lymphocytes Lysine Male Methyltransferase Middle Aged Mutation Mutation hot spots Oncology Oropharyngeal cancer Oropharyngeal Neoplasms - genetics Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - virology oropharyngeal squamous cell carcinoma Papillomavirus Infections - genetics Papillomavirus Infections - pathology Papillomavirus Infections - virology Phosphatidylinositol Proteins Receptor, Fibroblast Growth Factor, Type 3 - genetics Smoking Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - pathology Squamous Cell Carcinoma of Head and Neck - virology The Cancer Genome Atlas (TCGA) Therapeutic applications Throat cancer Tumors Whole Exome Sequencing
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