MicroRNA-132 attenuates cerebral injury by protecting blood-brain-barrier in MCAO mice

MicroRNAs (miRNAs) have been widely reported to induce posttranscriptional gene silencing and led to an explosion of new strategies for the treatment of human disease. It has been reported that the expression of MicroRNA-132 (miR-132) are altered both in the blood and brain after stroke. However, th...

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Veröffentlicht in:	Experimental neurology 2019-06, Vol.316, p.12-19
Hauptverfasser:	Zuo, Xiaokun, Lu, Jianfei, Manaenko, Anatol, Qi, Xin, Tang, Jiping, Mei, Qiyong, Xia, Ying, Hu, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial Occlusive Diseases - drug therapy Arterial Occlusive Diseases - pathology Arterial Occlusive Diseases - psychology BBB integrity Blood-Brain Barrier - pathology Brain Edema - pathology Brain Ischemia - drug therapy Brain Ischemia - pathology Brain Ischemia - psychology Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - psychology Injections, Intraventricular Ischemic stroke Male Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Mice Mice, Inbred C57BL MicroRNA-132 MicroRNAs - administration & dosage MicroRNAs - therapeutic use Middle Cerebral Artery MMP-9 Psychomotor Performance Stroke - drug therapy Stroke - pathology Stroke - psychology Tight Junction Proteins - metabolism
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