Selective antibacterial activity of the cationic peptide PaDBS1R6 against Gram-negative bacteria

Infections caused by Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa foremost among them, constitute a major worldwide health problem. Bioinformatics methodologies are being used to rationally design new antimicrobial peptides, a potential alternative for treating these infection...

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Veröffentlicht in:	Biochimica et biophysica acta. Biomembranes 2019-07, Vol.1861 (7), p.1375-1387
Hauptverfasser:	Fensterseifer, Isabel C.M., Felício, Mário R., Alves, Eliane S.F., Cardoso, Marlon H., Torres, Marcelo D.T., Matos, Carolina O., Silva, Osmar N., Lu, Timothy K., Freire, Maurício V., Neves, Natan C., Gonçalves, Sónia, Lião, Luciano M., Santos, Nuno C., Porto, William F., de la Fuente-Nunez, Cesar, Franco, Octavio L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibiotic resistance Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptide (AMP) Drug design Escherichia coli Gram-Negative Bacteria - drug effects Joker algorithm Mice Mice, Inbred C57BL Microbial Sensitivity Tests PaDBS1R6 Pseudomonas aeruginosa
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