The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice

Background and objectives Excessive adipose tissue macrophage accumulation in obesity has been implicated in mediating inflammatory responses that impair glucose homeostasis and promote insulin resistance. Colony-stimulating factor 1 (CSF1) controls macrophage differentiation, and here we sought to...

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Veröffentlicht in:	International Journal of Obesity 2020-01, Vol.44 (1), p.245-253
Hauptverfasser:	Merry, Troy L., Brooks, Anna E. S., Masson, Stewart W., Adams, Shannon E., Jaiswal, Jagdish K., Jamieson, Stephen M. F., Shepherd, Peter R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 38/77 631/443/319/1642/137/773 64 64/60 692/163/2743/2815 82 Adipose tissue Adipose Tissue - cytology Adipose Tissue - drug effects Adipose tissues Aminopyridines - pharmacology Animals Bioaccumulation Colony-stimulating factor Dextrose Diabetes therapy Diet Diet, High-Fat Epidemiology Ethylenediaminetetraacetic acid Extracellular signal-regulated kinase Glucose Glucose - metabolism Glucose tolerance Health Promotion and Disease Prevention High fat diet Homeostasis Homeostasis - drug effects Immune system Immunological tolerance Inflammation Inhibitors Instrument industry Insulin Insulin resistance Insulin Resistance - physiology Interleukin 6 Internal Medicine Kinases Macrophage colony-stimulating factor Macrophages Macrophages - drug effects Medicine Medicine & Public Health Metabolic Diseases Mice Obesity Phosphorylation Public Health Pyrroles - pharmacology Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Resistance factors Sensitivity analysis Type 2 diabetes
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