Endothelial biomarkers in the light of new sepsis definition
The aim of our study was to compare usefulness of endothelial biomarkers for severity and outcome prediction in patients with positive Sepsis-3 criteria with traditionally used biomarkers. A total of 150 patients were included in our study. Patients were divided into two groups: patients with sepsis...
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| Veröffentlicht in: | Biomarkers in medicine 2019-04, Vol.13 (5), p.341-351 |
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| container_title | Biomarkers in medicine |
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| creator | Mihajlovic, Dunja Brkic, Snezana Lendak, Dajana Mikic, Aleksandra Novakov Draskovic, Biljana Mitic, Gorana |
| description | The aim of our study was to compare usefulness of endothelial biomarkers for severity and outcome prediction in patients with positive Sepsis-3 criteria with traditionally used biomarkers. A total of 150 patients were included in our study. Patients were divided into two groups: patients with sepsis and those with infectious systemic inflammatory response syndrome. Development of septic shock and 28-day mortality were assessed. Endocan and thrombomodulin showed better discriminative power than procalcitonin for the presence of sepsis. Endocan showed good discriminative power for septic shock prediction. Addition of endocan significantly contributed to sequential (sepsis-related) organ failure assessment score in logistic regression model.
Endothelial biomarkers have a good diagnostic potential for sepsis. Endocan is useful as a predictor of the severity and fatality of sepsis. |
| doi_str_mv | 10.2217/bmm-2018-0282 |
| format | Article |
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Endothelial biomarkers have a good diagnostic potential for sepsis. Endocan is useful as a predictor of the severity and fatality of sepsis.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2018-0282</identifier><identifier>PMID: 30920847</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Adult ; Aged ; Antigens ; Biomarkers ; Biomarkers - metabolism ; Critical care ; Endothelium ; Endothelium - metabolism ; Female ; Humans ; Identification ; Infections ; Inflammation ; Laboratories ; Male ; Middle Aged ; Mortality ; Procalcitonin ; Proteins ; ROC Curve ; Sepsis ; Sepsis - diagnosis ; Sepsis - metabolism ; Septic shock ; shock ; Systemic inflammatory response syndrome ; Thrombomodulin</subject><ispartof>Biomarkers in medicine, 2019-04, Vol.13 (5), p.341-351</ispartof><rights>2019 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Apr 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-56307456cc7db448085a3ac37e8df64fc05e07d289e5cbfa4726f13a330f58d33</citedby><cites>FETCH-LOGICAL-c371t-56307456cc7db448085a3ac37e8df64fc05e07d289e5cbfa4726f13a330f58d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30920847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mihajlovic, Dunja</creatorcontrib><creatorcontrib>Brkic, Snezana</creatorcontrib><creatorcontrib>Lendak, Dajana</creatorcontrib><creatorcontrib>Mikic, Aleksandra Novakov</creatorcontrib><creatorcontrib>Draskovic, Biljana</creatorcontrib><creatorcontrib>Mitic, Gorana</creatorcontrib><title>Endothelial biomarkers in the light of new sepsis definition</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>The aim of our study was to compare usefulness of endothelial biomarkers for severity and outcome prediction in patients with positive Sepsis-3 criteria with traditionally used biomarkers. A total of 150 patients were included in our study. Patients were divided into two groups: patients with sepsis and those with infectious systemic inflammatory response syndrome. Development of septic shock and 28-day mortality were assessed. Endocan and thrombomodulin showed better discriminative power than procalcitonin for the presence of sepsis. Endocan showed good discriminative power for septic shock prediction. Addition of endocan significantly contributed to sequential (sepsis-related) organ failure assessment score in logistic regression model.
Endothelial biomarkers have a good diagnostic potential for sepsis. Endocan is useful as a predictor of the severity and fatality of sepsis.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Critical care</subject><subject>Endothelium</subject><subject>Endothelium - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Identification</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Laboratories</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Procalcitonin</subject><subject>Proteins</subject><subject>ROC Curve</subject><subject>Sepsis</subject><subject>Sepsis - diagnosis</subject><subject>Sepsis - metabolism</subject><subject>Septic shock</subject><subject>shock</subject><subject>Systemic inflammatory response syndrome</subject><subject>Thrombomodulin</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LxDAQhoMo7rp69CoFL16q06RpUvAiy_oBC170HNp04mZt07VpEf-9KV09CJ4ymXnyMnkIOU_gmtJE3JRNE1NIZAxU0gMyTwSnMTCRHP7WGZuRE--3AFyIjB6TGYOcgkzFnNyuXNX2G6xtUUelbZuie8fOR9ZFoRvV9m3TR62JHH5GHnfe-qhCY53tbetOyZEpao9n-3NBXu9XL8vHeP388LS8W8c67NHHPGMgUp5pLaoyTSVIXrAizFBWJkuNBo4gKipz5Lo0RSpoZhJWMAaGy4qxBbmacndd-zGg71Vjvca6Lhy2g1eUAghJ04wH9PIPum2HzoXtAiUygFzkIxVPlO5a7zs0atfZ8PUvlYAataqgVY1a1ag18Bf71KFssPqlfzwGIJ8AM_RDh15bdBrVdAsvrLYO_wn_BhpdhN8</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Mihajlovic, Dunja</creator><creator>Brkic, Snezana</creator><creator>Lendak, Dajana</creator><creator>Mikic, Aleksandra Novakov</creator><creator>Draskovic, Biljana</creator><creator>Mitic, Gorana</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Endothelial biomarkers in the light of new sepsis definition</title><author>Mihajlovic, Dunja ; Brkic, Snezana ; Lendak, Dajana ; Mikic, Aleksandra Novakov ; Draskovic, Biljana ; Mitic, Gorana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-56307456cc7db448085a3ac37e8df64fc05e07d289e5cbfa4726f13a330f58d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Critical care</topic><topic>Endothelium</topic><topic>Endothelium - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Identification</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Laboratories</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Procalcitonin</topic><topic>Proteins</topic><topic>ROC Curve</topic><topic>Sepsis</topic><topic>Sepsis - diagnosis</topic><topic>Sepsis - metabolism</topic><topic>Septic shock</topic><topic>shock</topic><topic>Systemic inflammatory response syndrome</topic><topic>Thrombomodulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mihajlovic, Dunja</creatorcontrib><creatorcontrib>Brkic, Snezana</creatorcontrib><creatorcontrib>Lendak, Dajana</creatorcontrib><creatorcontrib>Mikic, Aleksandra Novakov</creatorcontrib><creatorcontrib>Draskovic, Biljana</creatorcontrib><creatorcontrib>Mitic, Gorana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mihajlovic, Dunja</au><au>Brkic, Snezana</au><au>Lendak, Dajana</au><au>Mikic, Aleksandra Novakov</au><au>Draskovic, Biljana</au><au>Mitic, Gorana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial biomarkers in the light of new sepsis definition</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>13</volume><issue>5</issue><spage>341</spage><epage>351</epage><pages>341-351</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>The aim of our study was to compare usefulness of endothelial biomarkers for severity and outcome prediction in patients with positive Sepsis-3 criteria with traditionally used biomarkers. A total of 150 patients were included in our study. Patients were divided into two groups: patients with sepsis and those with infectious systemic inflammatory response syndrome. Development of septic shock and 28-day mortality were assessed. Endocan and thrombomodulin showed better discriminative power than procalcitonin for the presence of sepsis. Endocan showed good discriminative power for septic shock prediction. Addition of endocan significantly contributed to sequential (sepsis-related) organ failure assessment score in logistic regression model.
Endothelial biomarkers have a good diagnostic potential for sepsis. Endocan is useful as a predictor of the severity and fatality of sepsis.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>30920847</pmid><doi>10.2217/bmm-2018-0282</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Aged Antigens Biomarkers Biomarkers - metabolism Critical care Endothelium Endothelium - metabolism Female Humans Identification Infections Inflammation Laboratories Male Middle Aged Mortality Procalcitonin Proteins ROC Curve Sepsis Sepsis - diagnosis Sepsis - metabolism Septic shock shock Systemic inflammatory response syndrome Thrombomodulin |
| title | Endothelial biomarkers in the light of new sepsis definition |
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