Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma
Background Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study was to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2019-07, Vol.48 (6), p.451-458 |
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| container_title | Journal of oral pathology & medicine |
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| creator | Xie, Nan Yu, Pei Liu, Haichao Liu, Xiqiang Hou, Jinsong Chen, Xiaohua Huang, Hongzhang Wang, Cheng |
| description | Background
Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study was to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.
Methods
Tumor budding was scored as ITBCC recommended in 255 patients with OTSCC. Then, associations between tumor budding and clinicopathologic parameters were examined. Among them, 136 patients with follow‐up data available were used to evaluate overall survival (OS) by the Kaplan‐Meier method. Prognostic value of tumor budding was assessed by Cox regression analysis. The inter‐observer and intra‐observer agreement was calculated by the kappa statistic.
Results
Tumor budding score was associated with lymph node metastasis, differentiation, invasive pattern, lymphoid infiltrate, tumor relapse, invasive depth, and reduced OS in OTSCC patients. The Cox analysis showed high budding score was an independent prognostic factor in patients with all clinical stage and patients with clinical early‐stage OTSCC. The high kappa values were achieved in intra‐observer and inter‐observer.
Conclusions
International Tumor Budding Consensus Conference scoring system is a simple, reliable, and reproducible method to measure tumor budding in OTSCC, which should be included in the routine pathological report. |
| doi_str_mv | 10.1111/jop.12856 |
| format | Article |
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Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study was to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.
Methods
Tumor budding was scored as ITBCC recommended in 255 patients with OTSCC. Then, associations between tumor budding and clinicopathologic parameters were examined. Among them, 136 patients with follow‐up data available were used to evaluate overall survival (OS) by the Kaplan‐Meier method. Prognostic value of tumor budding was assessed by Cox regression analysis. The inter‐observer and intra‐observer agreement was calculated by the kappa statistic.
Results
Tumor budding score was associated with lymph node metastasis, differentiation, invasive pattern, lymphoid infiltrate, tumor relapse, invasive depth, and reduced OS in OTSCC patients. The Cox analysis showed high budding score was an independent prognostic factor in patients with all clinical stage and patients with clinical early‐stage OTSCC. The high kappa values were achieved in intra‐observer and inter‐observer.
Conclusions
International Tumor Budding Consensus Conference scoring system is a simple, reliable, and reproducible method to measure tumor budding in OTSCC, which should be included in the routine pathological report.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.12856</identifier><identifier>PMID: 30927486</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - pathology ; Dentistry ; Humans ; Invasiveness ; ITBCC scoring system ; Lymph nodes ; Metastases ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Oral cancer ; oral tongue squamous cell carcinoma ; Prognosis ; Squamous cell carcinoma ; survival ; Tongue ; Tongue Neoplasms - diagnosis ; Tongue Neoplasms - pathology ; tumor budding</subject><ispartof>Journal of oral pathology & medicine, 2019-07, Vol.48 (6), p.451-458</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-be14e4cffa4c8eb0366613b3b080be3298e66327aab258e5f06a79b96a223cc23</citedby><cites>FETCH-LOGICAL-c3536-be14e4cffa4c8eb0366613b3b080be3298e66327aab258e5f06a79b96a223cc23</cites><orcidid>0000-0001-8155-5064</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.12856$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.12856$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30927486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Nan</creatorcontrib><creatorcontrib>Yu, Pei</creatorcontrib><creatorcontrib>Liu, Haichao</creatorcontrib><creatorcontrib>Liu, Xiqiang</creatorcontrib><creatorcontrib>Hou, Jinsong</creatorcontrib><creatorcontrib>Chen, Xiaohua</creatorcontrib><creatorcontrib>Huang, Hongzhang</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><title>Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background
Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study was to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.
Methods
Tumor budding was scored as ITBCC recommended in 255 patients with OTSCC. Then, associations between tumor budding and clinicopathologic parameters were examined. Among them, 136 patients with follow‐up data available were used to evaluate overall survival (OS) by the Kaplan‐Meier method. Prognostic value of tumor budding was assessed by Cox regression analysis. The inter‐observer and intra‐observer agreement was calculated by the kappa statistic.
Results
Tumor budding score was associated with lymph node metastasis, differentiation, invasive pattern, lymphoid infiltrate, tumor relapse, invasive depth, and reduced OS in OTSCC patients. The Cox analysis showed high budding score was an independent prognostic factor in patients with all clinical stage and patients with clinical early‐stage OTSCC. The high kappa values were achieved in intra‐observer and inter‐observer.
Conclusions
International Tumor Budding Consensus Conference scoring system is a simple, reliable, and reproducible method to measure tumor budding in OTSCC, which should be included in the routine pathological report.</description><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Dentistry</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>ITBCC scoring system</subject><subject>Lymph nodes</subject><subject>Metastases</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Oral cancer</subject><subject>oral tongue squamous cell carcinoma</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><subject>survival</subject><subject>Tongue</subject><subject>Tongue Neoplasms - diagnosis</subject><subject>Tongue Neoplasms - pathology</subject><subject>tumor budding</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LxDAQhoMoun4c_AMS8LIeqpOPpu1RFz8R9KBeS5qdapc2WZMW8eZPN2vVg2AuE4ZnHoZ5CdlncMziO1m45THjearWyIQpgAQyJtfJBAqQCU8Z3yLbISwAWCYk2yRbAgqeyVxNyMeTbpu57htnqatp_4L02vbo7VdLt_Rh6JynZ8N83thnOnM2oA1DWP1q9GgN0ikHpo6oR-O6Du1oC7SJRh8NvbPPA9LwOujOxUmDbUuN9qaxrtO7ZKPWbcC977pDHi_OH2ZXye3d5fXs9DYxIhUqqZBJlKautTQ5ViCUUkxUooIcKhS8yFEpwTOtK57mmNagdFZUhdKcC2O42CHT0bv07nXA0JddE1araItxq5JzgCyHlImIHv5BF26IF2lXVJrJQgmZRupopIx3IXisy6VvOu3fSwblKpY4tSy_YonswbdxqDqc_5I_OUTgZATemhbf_zeVN3f3o_ITWwWXMA</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Xie, Nan</creator><creator>Yu, Pei</creator><creator>Liu, Haichao</creator><creator>Liu, Xiqiang</creator><creator>Hou, Jinsong</creator><creator>Chen, Xiaohua</creator><creator>Huang, Hongzhang</creator><creator>Wang, Cheng</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8155-5064</orcidid></search><sort><creationdate>201907</creationdate><title>Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma</title><author>Xie, Nan ; Yu, Pei ; Liu, Haichao ; Liu, Xiqiang ; Hou, Jinsong ; Chen, Xiaohua ; Huang, Hongzhang ; Wang, Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-be14e4cffa4c8eb0366613b3b080be3298e66327aab258e5f06a79b96a223cc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Dentistry</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>ITBCC scoring system</topic><topic>Lymph nodes</topic><topic>Metastases</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Oral cancer</topic><topic>oral tongue squamous cell carcinoma</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><topic>survival</topic><topic>Tongue</topic><topic>Tongue Neoplasms - diagnosis</topic><topic>Tongue Neoplasms - pathology</topic><topic>tumor budding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Nan</creatorcontrib><creatorcontrib>Yu, Pei</creatorcontrib><creatorcontrib>Liu, Haichao</creatorcontrib><creatorcontrib>Liu, Xiqiang</creatorcontrib><creatorcontrib>Hou, Jinsong</creatorcontrib><creatorcontrib>Chen, Xiaohua</creatorcontrib><creatorcontrib>Huang, Hongzhang</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Nan</au><au>Yu, Pei</au><au>Liu, Haichao</au><au>Liu, Xiqiang</au><au>Hou, Jinsong</au><au>Chen, Xiaohua</au><au>Huang, Hongzhang</au><au>Wang, Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2019-07</date><risdate>2019</risdate><volume>48</volume><issue>6</issue><spage>451</spage><epage>458</epage><pages>451-458</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background
Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study was to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.
Methods
Tumor budding was scored as ITBCC recommended in 255 patients with OTSCC. Then, associations between tumor budding and clinicopathologic parameters were examined. Among them, 136 patients with follow‐up data available were used to evaluate overall survival (OS) by the Kaplan‐Meier method. Prognostic value of tumor budding was assessed by Cox regression analysis. The inter‐observer and intra‐observer agreement was calculated by the kappa statistic.
Results
Tumor budding score was associated with lymph node metastasis, differentiation, invasive pattern, lymphoid infiltrate, tumor relapse, invasive depth, and reduced OS in OTSCC patients. The Cox analysis showed high budding score was an independent prognostic factor in patients with all clinical stage and patients with clinical early‐stage OTSCC. The high kappa values were achieved in intra‐observer and inter‐observer.
Conclusions
International Tumor Budding Consensus Conference scoring system is a simple, reliable, and reproducible method to measure tumor budding in OTSCC, which should be included in the routine pathological report.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30927486</pmid><doi>10.1111/jop.12856</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8155-5064</orcidid></addata></record> |
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| subjects | Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Dentistry Humans Invasiveness ITBCC scoring system Lymph nodes Metastases Neoplasm Recurrence, Local Neoplasm Staging Oral cancer oral tongue squamous cell carcinoma Prognosis Squamous cell carcinoma survival Tongue Tongue Neoplasms - diagnosis Tongue Neoplasms - pathology tumor budding |
| title | Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma |
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