Changes of the postcentral cortex in irritable bowel syndrome patients
The postcentral cortex (poCC) is commonly found to respond to visceral stimulation, but researchers usually pay less attention to this role of the poCC in the patients with functional gastrointestinal disorders, because it is a primary receptor for general bodily feeling of touch, such as temperatur...
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| Veröffentlicht in: | Brain imaging and behavior 2020-10, Vol.14 (5), p.1566-1576 |
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| creator | Nan, Jiaofen Yang, Wenya Meng, Panting Huang, Wei Zheng, Qian Xia, Yongquan Liu, Feng |
| description | The postcentral cortex (poCC) is commonly found to respond to visceral stimulation, but researchers usually pay less attention to this role of the poCC in the patients with functional gastrointestinal disorders, because it is a primary receptor for general bodily feeling of touch, such as temperature and pain. The current study focuses on the changes around the poCC in irritable bowel syndrome (IBS) patients based on the resting-state functional magnetic resonance imaging, aiming to investigate whether the poCC-centric brain metrics may be directly related to visceral perception. In the study, we calculated the regional homogeneity, seed-based correlation (SBC) and nodal centralities of the poCC to explore the changes in the regional activity and information flow around the poCC in IBS patients. Moreover, we examined the performance of the poCC-centric features in classifying the IBS group and healthy group in comparison to those features unrelated to the poCC. The results found that central alterations around the poCC in IBS patients were associated with the level of visceral pain, and exhibited a better discriminative power than those around the whole brain and the insula when classifying the IBS group and healthy group. In conclusion, the preliminary investigation provided fundamental advances in understanding the roles of the poCC in the pathphysiology of the IBS. |
| doi_str_mv | 10.1007/s11682-019-00087-7 |
| format | Article |
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The current study focuses on the changes around the poCC in irritable bowel syndrome (IBS) patients based on the resting-state functional magnetic resonance imaging, aiming to investigate whether the poCC-centric brain metrics may be directly related to visceral perception. In the study, we calculated the regional homogeneity, seed-based correlation (SBC) and nodal centralities of the poCC to explore the changes in the regional activity and information flow around the poCC in IBS patients. Moreover, we examined the performance of the poCC-centric features in classifying the IBS group and healthy group in comparison to those features unrelated to the poCC. The results found that central alterations around the poCC in IBS patients were associated with the level of visceral pain, and exhibited a better discriminative power than those around the whole brain and the insula when classifying the IBS group and healthy group. In conclusion, the preliminary investigation provided fundamental advances in understanding the roles of the poCC in the pathphysiology of the IBS.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-019-00087-7</identifier><identifier>PMID: 30927201</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain Mapping ; Cerebral Cortex - diagnostic imaging ; Classification ; Colon ; Functional magnetic resonance imaging ; Gastrointestinal diseases ; Homogeneity ; Humans ; Information flow ; Intestine ; Irritable bowel syndrome ; Irritable Bowel Syndrome - diagnostic imaging ; Magnetic Resonance Imaging ; Neuroimaging ; Neuropsychology ; Neuroradiology ; Neurosciences ; Original Research ; Pain ; Patients ; Psychiatry</subject><ispartof>Brain imaging and behavior, 2020-10, Vol.14 (5), p.1566-1576</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Brain Imaging and Behavior is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-30cb8d90dd1374640d5ccc69024082164a4bd8e954fc82eb4e2ec5e3dfaea943</citedby><cites>FETCH-LOGICAL-c375t-30cb8d90dd1374640d5ccc69024082164a4bd8e954fc82eb4e2ec5e3dfaea943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-019-00087-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-019-00087-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30927201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nan, Jiaofen</creatorcontrib><creatorcontrib>Yang, Wenya</creatorcontrib><creatorcontrib>Meng, Panting</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><creatorcontrib>Zheng, Qian</creatorcontrib><creatorcontrib>Xia, Yongquan</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><title>Changes of the postcentral cortex in irritable bowel syndrome patients</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><addtitle>Brain Imaging Behav</addtitle><description>The postcentral cortex (poCC) is commonly found to respond to visceral stimulation, but researchers usually pay less attention to this role of the poCC in the patients with functional gastrointestinal disorders, because it is a primary receptor for general bodily feeling of touch, such as temperature and pain. The current study focuses on the changes around the poCC in irritable bowel syndrome (IBS) patients based on the resting-state functional magnetic resonance imaging, aiming to investigate whether the poCC-centric brain metrics may be directly related to visceral perception. In the study, we calculated the regional homogeneity, seed-based correlation (SBC) and nodal centralities of the poCC to explore the changes in the regional activity and information flow around the poCC in IBS patients. Moreover, we examined the performance of the poCC-centric features in classifying the IBS group and healthy group in comparison to those features unrelated to the poCC. The results found that central alterations around the poCC in IBS patients were associated with the level of visceral pain, and exhibited a better discriminative power than those around the whole brain and the insula when classifying the IBS group and healthy group. In conclusion, the preliminary investigation provided fundamental advances in understanding the roles of the poCC in the pathphysiology of the IBS.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Classification</subject><subject>Colon</subject><subject>Functional magnetic resonance imaging</subject><subject>Gastrointestinal diseases</subject><subject>Homogeneity</subject><subject>Humans</subject><subject>Information flow</subject><subject>Intestine</subject><subject>Irritable bowel syndrome</subject><subject>Irritable Bowel Syndrome - diagnostic imaging</subject><subject>Magnetic Resonance Imaging</subject><subject>Neuroimaging</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Pain</subject><subject>Patients</subject><subject>Psychiatry</subject><issn>1931-7557</issn><issn>1931-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LxDAQhoMofqz-AQ9S8OKlOvlqkqMsrgoLXryHNJ1qpdusSRfdf2_W9QM8eJqBeead4SHklMIlBVBXidJKsxKoKQFAq1LtkENqOC2VrOTuTy_VATlK6QVACm3oPjngYJhiQA_JbPrshidMRWiL8RmLZUijx2GMri98iCO-F91QdDF2o6t7LOrwhn2R1kMTwyLjbuwynY7JXuv6hCdfdUIeZzeP07ty_nB7P72el54rOZYcfK0bA01DuRKVgEZ67ysDTIBmtBJO1I1GI0XrNcNaIEMvkTetQ2cEn5CLbewyhtcVptEuuuSx792AYZUsY9mLMlxu0PM_6EtYxSE_Zxk1pqJUS50ptqV8DClFbO0ydgsX15aC3Ui2W8k2S7afkq3KS2df0at6gc3PyrfVDPAtkPIo242_t_-J_QAfX4cc</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Nan, Jiaofen</creator><creator>Yang, Wenya</creator><creator>Meng, Panting</creator><creator>Huang, Wei</creator><creator>Zheng, Qian</creator><creator>Xia, Yongquan</creator><creator>Liu, Feng</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20201001</creationdate><title>Changes of the postcentral cortex in irritable bowel syndrome patients</title><author>Nan, Jiaofen ; Yang, Wenya ; Meng, Panting ; Huang, Wei ; Zheng, Qian ; Xia, Yongquan ; Liu, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-30cb8d90dd1374640d5ccc69024082164a4bd8e954fc82eb4e2ec5e3dfaea943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Classification</topic><topic>Colon</topic><topic>Functional magnetic resonance imaging</topic><topic>Gastrointestinal diseases</topic><topic>Homogeneity</topic><topic>Humans</topic><topic>Information flow</topic><topic>Intestine</topic><topic>Irritable bowel syndrome</topic><topic>Irritable Bowel Syndrome - diagnostic imaging</topic><topic>Magnetic Resonance Imaging</topic><topic>Neuroimaging</topic><topic>Neuropsychology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Research</topic><topic>Pain</topic><topic>Patients</topic><topic>Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nan, Jiaofen</creatorcontrib><creatorcontrib>Yang, Wenya</creatorcontrib><creatorcontrib>Meng, Panting</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><creatorcontrib>Zheng, Qian</creatorcontrib><creatorcontrib>Xia, Yongquan</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain imaging and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nan, Jiaofen</au><au>Yang, Wenya</au><au>Meng, Panting</au><au>Huang, Wei</au><au>Zheng, Qian</au><au>Xia, Yongquan</au><au>Liu, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes of the postcentral cortex in irritable bowel syndrome patients</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><addtitle>Brain Imaging Behav</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>14</volume><issue>5</issue><spage>1566</spage><epage>1576</epage><pages>1566-1576</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>The postcentral cortex (poCC) is commonly found to respond to visceral stimulation, but researchers usually pay less attention to this role of the poCC in the patients with functional gastrointestinal disorders, because it is a primary receptor for general bodily feeling of touch, such as temperature and pain. The current study focuses on the changes around the poCC in irritable bowel syndrome (IBS) patients based on the resting-state functional magnetic resonance imaging, aiming to investigate whether the poCC-centric brain metrics may be directly related to visceral perception. In the study, we calculated the regional homogeneity, seed-based correlation (SBC) and nodal centralities of the poCC to explore the changes in the regional activity and information flow around the poCC in IBS patients. Moreover, we examined the performance of the poCC-centric features in classifying the IBS group and healthy group in comparison to those features unrelated to the poCC. The results found that central alterations around the poCC in IBS patients were associated with the level of visceral pain, and exhibited a better discriminative power than those around the whole brain and the insula when classifying the IBS group and healthy group. In conclusion, the preliminary investigation provided fundamental advances in understanding the roles of the poCC in the pathphysiology of the IBS.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30927201</pmid><doi>10.1007/s11682-019-00087-7</doi><tpages>11</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Brain Brain Mapping Cerebral Cortex - diagnostic imaging Classification Colon Functional magnetic resonance imaging Gastrointestinal diseases Homogeneity Humans Information flow Intestine Irritable bowel syndrome Irritable Bowel Syndrome - diagnostic imaging Magnetic Resonance Imaging Neuroimaging Neuropsychology Neuroradiology Neurosciences Original Research Pain Patients Psychiatry |
| title | Changes of the postcentral cortex in irritable bowel syndrome patients |
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