Co-delivery of antigen and dual agonists by programmed mannose-targeted cationic lipid-hybrid polymersomes for enhanced vaccination

Exploiting Toll-like receptor (TLR) agonists or their certain combinations can enhance the immune potency of subunit vaccine. Nevertheless, the design of co-delivery systems which can act in a synergistic and spatio-temporal way to achieve effective and durable specific immune response is still chal...

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Veröffentlicht in:	Biomaterials 2019-06, Vol.206, p.25-40
Hauptverfasser:	Zhu, Dunwan, Hu, Chunyan, Fan, Fan, Qin, Yu, Huang, Chenlu, Zhang, Zhiming, Lu, Lu, Wang, Hai, Sun, Hongfan, Leng, Xigang, Wang, Chun, Kong, Deling, Zhang, Linhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen delivery Cancer vaccine Imiquimod Lipid-hybrid polymersomes Mannose-receptor targeting Monophosphoryl lipid A
Online-Zugang:	Volltext
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