AMPK‐mediated degradation of Nav1.5 through autophagy

ABSTRACTThe voltage‐gated cardiac sodium channel, Nav1.5, is the key component that controls cardiac excitative electrical impulse and propagation. However, the dynamic alterations of Nav1.5 during cardiac ischemia and reperfusion (I/R) are seldom reported. We found that the protein levels of rat ca...

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Veröffentlicht in:	The FASEB journal 2019-04, Vol.33 (4), p.5366-5376
Hauptverfasser:	Liu, Xuehua, Chen, Zheng, Han, Zhonglin, Liu, Yu, Wu, Xiang, Peng, Yuzhu, Di, Wencheng, Lan, Rongfang, Sun, Bugao, Xu, Biao, Xu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Animals, Newborn Autophagy - physiology Immunoprecipitation ischemia and reperfusion injury Male Muscle Cells - metabolism Myocytes, Cardiac - metabolism NAV1.5 Voltage-Gated Sodium Channel - metabolism Phosphorylation protein degradation Rats Rats, Sprague-Dawley Reperfusion Injury - metabolism Reverse Transcriptase Polymerase Chain Reaction SCN5A Signal Transduction sodium channel
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