IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer

Tumor immune reactions not only provide host defense but also accelerate tumor immune escape and phenotype switching. Here, we examined the association of programmed cell death ligand 1 (PD-L1) expression with epithelial-mesenchymal transition (EMT)–associated markers in pancreatic ductal adenocarci...

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Veröffentlicht in:	The Journal of surgical research 2019-08, Vol.240, p.115-123
Hauptverfasser:	Imai, Daisuke, Yoshizumi, Tomoharu, Okano, Shinji, Itoh, Shinji, Ikegami, Toru, Harada, Noboru, Aishima, Shinichi, Oda, Yoshinao, Maehara, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - immunology B7-H1 Antigen - metabolism Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - immunology Female Humans Interferon gamma Interferon-gamma - immunology Interferon-gamma - metabolism Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Pancreas - immunology Pancreas - pathology Pancreas - surgery Pancreatectomy Pancreatic cancer Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Programmed cell death ligand 1 RNA, Small Interfering - metabolism STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Vimentin - immunology Vimentin - metabolism
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