Quadrupole Dalton-Based Controlled Proteolysis Method for Characterization of Higher Order Protein Structure

The higher order structure (HOS) of proteins plays a critical role in the efficacy and stability of biological drugs. Perturbation of the regional structure of proteins can affect biological activity and cause instability. Characterization of HOS has become an integral part of biological drug develo...

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Veröffentlicht in:	Analytical chemistry (Washington) 2019-04, Vol.91 (8), p.5339-5345
Hauptverfasser:	Cao, Xiang, Flagg, Shannon C, Li, Xue, Chennamsetty, Naresh, Balakrishnan, Gurusamy, Das, Tapan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Biological products Calorimetry Change detection Chemistry Circular dichroism Denaturation Deuterium Dichroism Differential scanning calorimetry Digestion Domains Drug development Fluorescence Fourier transforms Instrumentation Liquid chromatography Mass spectrometry Mass spectroscopy Peptides Protein structure Proteins Proteolysis Quadrupoles Regulatory agencies Sensitivity
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