Accumulation of hyaluronic acid in stromal cells modulates osteoclast formation by regulation of receptor activator of nuclear factor kappa-B ligand expression

Hyaluronic acid (HA) has a pivotal role in bone and cartilage metabolism. In this study, we investigated the effect and underlying mechanisms of HA accumulation on the expression of receptor activator of nuclear factor kappa-B ligand (RANKL) induced by 1α,25(OH)2D3 and dexamethasone in stromal cells...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-05, Vol.512 (3), p.537-543
Hauptverfasser:	Nakao, Yuko, Hikiji, Hisako, Okinaga, Toshinori, Takeuchi, Jun, Habu, Manabu, Yoshiga, Daigo, Yoshioka, Izumi, Nishihara, Tatsuji, Ariyoshi, Wataru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cells, Cultured Hyaluronic acid Hyaluronic Acid - metabolism Hyaluronidase Male Mice Osteoclast Osteoclasts - cytology Osteoclasts - metabolism Osteogenesis RANK Ligand - metabolism Receptor activator of nuclear factor kappa-B ligand (RANKL) Signal transducers and activator of transcription 3 (STAT3) Stromal Cells - cytology Stromal Cells - metabolism Vitamin D receptor (VDR)
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