Structural basis for substrate binding to human pyridoxal 5′-phosphate phosphatase/chronophin by a conformational change

Human pyridoxal 5′-phosphate phosphatase (PLPP), also known as a chronophin, is a phosphatase belonging to subfamily II of the HAD phosphatases, characterized by a large cap domain. As a member of the subfamily, its cap-open conformation is expected for substrate binding. We determined apo and PLP-b...

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Veröffentlicht in:	International journal of biological macromolecules 2019-06, Vol.131, p.912-924
Hauptverfasser:	Cho, Hyo Je, Lee, Hyun Joo, Cho, Ha Yeon, Park, Jeen-Woo, Lee, Dong-Seok, Lee, Hyun-Shik, Kwon, Oh-Shin, Kang, Beom Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronophin Crystal structure HAD phosphatase Phosphotransfer Pyridoxal-5′-phosphate phosphatase
Online-Zugang:	Volltext
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