Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin
Objectives This study aimed to revisit benign odontogenic ghost cell lesions (BOGCL) by hematoxylin and eosin staining and immunohistochemistry. Materials and methods Thirty cases of calcifying odontogenic cyst (COC) and 6 cases of dentinogenic ghost cell tumor (DGCT) were selected for histopatholog...
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| Veröffentlicht in: | Clinical oral investigations 2019-12, Vol.23 (12), p.4335-4343 |
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| creator | Rosa, Ana Cláudia Garcia Teixeira, Lucas Novaes Passador-Santos, Fabricio Furuse, Cristiane Montalli, Victor Ângelo Martins de Araújo, Ney Soares de Araújo, Vera Cavalcanti |
| description | Objectives
This study aimed to revisit benign odontogenic ghost cell lesions (BOGCL) by hematoxylin and eosin staining and immunohistochemistry.
Materials and methods
Thirty cases of calcifying odontogenic cyst (COC) and 6 cases of dentinogenic ghost cell tumor (DGCT) were selected for histopathological and immunohistochemical analysis. Sections stained for cytokeratin (K) 14, K-19, amelogenin, collagen type 1 (COL-1), and dentin matrix acidic phosphoprotein 1 (DMP-1) were evaluated using qualitative analysis. Sections stained for Ki-67 and minichromosome maintenance protein-2 (MCM-2) were evaluated using semi-quantitative analysis.
Results
A morphologic overlap was noticed in all BOGCL. Moreover, no differences were detected in the expression of K-14 and K-19. The expression of proliferative markers Ki-67 and MCM-2 was similar between cystic and tumor lesions (
p
> .05). The presence of COL-1 and absence of amelogenin in the so-called dysplastic dentin, associated with its histologic pattern, suggest that this is in fact an enameloid-like tissue.
Conclusions
The dysplastic dentin should be considered an enameloid-like tissue in these lesions.
Clinical relevance
The similarity in histology, protein expression, and proliferative marker indices between COC and DGCT suggest that they are a sole entity and likely represent types of the same neoplasia. |
| doi_str_mv | 10.1007/s00784-019-02863-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2197889155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2197038396</sourcerecordid><originalsourceid>FETCH-LOGICAL-p213t-44aa1c1f18d02bcfb0a28f78433a1be81edf0c8618f134d878714d7212f4ab6c3</originalsourceid><addsrcrecordid>eNpdkU1PwzAMhiMEYmPwBzigSFy4FOIma9IjTHxJk7jAiUOUNmnp1CWlSUH792TdEBKXOLYfvbL9InQO5BoI4Tc-PoIlBPKEpCKjCT9AU2A0SyjncDj-0yTLBUzQifcrQoBlnB6jCSU5gGBsit7vjG1qi512Nrg6JiWuP5wPuDRti1vjG2c97s1X45tgNFZWY2u-cRnLjTa9CiPgLNYb37XKh6igjQ2NPUVHlWq9OdvHGXp7uH9dPCXLl8fnxe0y6VKgIWFMKSihAqFJWpRVQVQqqrgZpQoKI8DoipQiA1EBZVpwwYFpnkJaMVVkJZ2hq51u17vPwfgg143fjq-scYOXKeRciBzm84he_kNXbuhtnG6kCBU0zyJ1saeGYm207PpmrfqN_D1bBOgO8LFla9P_yQCRW3PkzhwZzZGjOZLTH4ozf-s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2197038396</pqid></control><display><type>article</type><title>Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Rosa, Ana Cláudia Garcia ; Teixeira, Lucas Novaes ; Passador-Santos, Fabricio ; Furuse, Cristiane ; Montalli, Victor Ângelo Martins ; de Araújo, Ney Soares ; de Araújo, Vera Cavalcanti</creator><creatorcontrib>Rosa, Ana Cláudia Garcia ; Teixeira, Lucas Novaes ; Passador-Santos, Fabricio ; Furuse, Cristiane ; Montalli, Victor Ângelo Martins ; de Araújo, Ney Soares ; de Araújo, Vera Cavalcanti</creatorcontrib><description>Objectives
This study aimed to revisit benign odontogenic ghost cell lesions (BOGCL) by hematoxylin and eosin staining and immunohistochemistry.
Materials and methods
Thirty cases of calcifying odontogenic cyst (COC) and 6 cases of dentinogenic ghost cell tumor (DGCT) were selected for histopathological and immunohistochemical analysis. Sections stained for cytokeratin (K) 14, K-19, amelogenin, collagen type 1 (COL-1), and dentin matrix acidic phosphoprotein 1 (DMP-1) were evaluated using qualitative analysis. Sections stained for Ki-67 and minichromosome maintenance protein-2 (MCM-2) were evaluated using semi-quantitative analysis.
Results
A morphologic overlap was noticed in all BOGCL. Moreover, no differences were detected in the expression of K-14 and K-19. The expression of proliferative markers Ki-67 and MCM-2 was similar between cystic and tumor lesions (
p
> .05). The presence of COL-1 and absence of amelogenin in the so-called dysplastic dentin, associated with its histologic pattern, suggest that this is in fact an enameloid-like tissue.
Conclusions
The dysplastic dentin should be considered an enameloid-like tissue in these lesions.
Clinical relevance
The similarity in histology, protein expression, and proliferative marker indices between COC and DGCT suggest that they are a sole entity and likely represent types of the same neoplasia.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-019-02863-7</identifier><identifier>PMID: 30911844</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Benign ; Collagen Type I ; Cytokeratin ; Dental enamel ; Dentin ; Dentistry ; Dmp1 protein ; Humans ; Immunohistochemistry ; Keratins ; Medicine ; Odontogenic Cyst, Calcifying ; Odontogenic Tumors ; Original Article</subject><ispartof>Clinical oral investigations, 2019-12, Vol.23 (12), p.4335-4343</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Clinical Oral Investigations is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-8566-3174</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-019-02863-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-019-02863-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30911844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosa, Ana Cláudia Garcia</creatorcontrib><creatorcontrib>Teixeira, Lucas Novaes</creatorcontrib><creatorcontrib>Passador-Santos, Fabricio</creatorcontrib><creatorcontrib>Furuse, Cristiane</creatorcontrib><creatorcontrib>Montalli, Victor Ângelo Martins</creatorcontrib><creatorcontrib>de Araújo, Ney Soares</creatorcontrib><creatorcontrib>de Araújo, Vera Cavalcanti</creatorcontrib><title>Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
This study aimed to revisit benign odontogenic ghost cell lesions (BOGCL) by hematoxylin and eosin staining and immunohistochemistry.
Materials and methods
Thirty cases of calcifying odontogenic cyst (COC) and 6 cases of dentinogenic ghost cell tumor (DGCT) were selected for histopathological and immunohistochemical analysis. Sections stained for cytokeratin (K) 14, K-19, amelogenin, collagen type 1 (COL-1), and dentin matrix acidic phosphoprotein 1 (DMP-1) were evaluated using qualitative analysis. Sections stained for Ki-67 and minichromosome maintenance protein-2 (MCM-2) were evaluated using semi-quantitative analysis.
Results
A morphologic overlap was noticed in all BOGCL. Moreover, no differences were detected in the expression of K-14 and K-19. The expression of proliferative markers Ki-67 and MCM-2 was similar between cystic and tumor lesions (
p
> .05). The presence of COL-1 and absence of amelogenin in the so-called dysplastic dentin, associated with its histologic pattern, suggest that this is in fact an enameloid-like tissue.
Conclusions
The dysplastic dentin should be considered an enameloid-like tissue in these lesions.
Clinical relevance
The similarity in histology, protein expression, and proliferative marker indices between COC and DGCT suggest that they are a sole entity and likely represent types of the same neoplasia.</description><subject>Benign</subject><subject>Collagen Type I</subject><subject>Cytokeratin</subject><subject>Dental enamel</subject><subject>Dentin</subject><subject>Dentistry</subject><subject>Dmp1 protein</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratins</subject><subject>Medicine</subject><subject>Odontogenic Cyst, Calcifying</subject><subject>Odontogenic Tumors</subject><subject>Original Article</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1PwzAMhiMEYmPwBzigSFy4FOIma9IjTHxJk7jAiUOUNmnp1CWlSUH792TdEBKXOLYfvbL9InQO5BoI4Tc-PoIlBPKEpCKjCT9AU2A0SyjncDj-0yTLBUzQifcrQoBlnB6jCSU5gGBsit7vjG1qi512Nrg6JiWuP5wPuDRti1vjG2c97s1X45tgNFZWY2u-cRnLjTa9CiPgLNYb37XKh6igjQ2NPUVHlWq9OdvHGXp7uH9dPCXLl8fnxe0y6VKgIWFMKSihAqFJWpRVQVQqqrgZpQoKI8DoipQiA1EBZVpwwYFpnkJaMVVkJZ2hq51u17vPwfgg143fjq-scYOXKeRciBzm84he_kNXbuhtnG6kCBU0zyJ1saeGYm207PpmrfqN_D1bBOgO8LFla9P_yQCRW3PkzhwZzZGjOZLTH4ozf-s</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Rosa, Ana Cláudia Garcia</creator><creator>Teixeira, Lucas Novaes</creator><creator>Passador-Santos, Fabricio</creator><creator>Furuse, Cristiane</creator><creator>Montalli, Victor Ângelo Martins</creator><creator>de Araújo, Ney Soares</creator><creator>de Araújo, Vera Cavalcanti</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8566-3174</orcidid></search><sort><creationdate>20191201</creationdate><title>Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin</title><author>Rosa, Ana Cláudia Garcia ; Teixeira, Lucas Novaes ; Passador-Santos, Fabricio ; Furuse, Cristiane ; Montalli, Victor Ângelo Martins ; de Araújo, Ney Soares ; de Araújo, Vera Cavalcanti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p213t-44aa1c1f18d02bcfb0a28f78433a1be81edf0c8618f134d878714d7212f4ab6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Benign</topic><topic>Collagen Type I</topic><topic>Cytokeratin</topic><topic>Dental enamel</topic><topic>Dentin</topic><topic>Dentistry</topic><topic>Dmp1 protein</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratins</topic><topic>Medicine</topic><topic>Odontogenic Cyst, Calcifying</topic><topic>Odontogenic Tumors</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosa, Ana Cláudia Garcia</creatorcontrib><creatorcontrib>Teixeira, Lucas Novaes</creatorcontrib><creatorcontrib>Passador-Santos, Fabricio</creatorcontrib><creatorcontrib>Furuse, Cristiane</creatorcontrib><creatorcontrib>Montalli, Victor Ângelo Martins</creatorcontrib><creatorcontrib>de Araújo, Ney Soares</creatorcontrib><creatorcontrib>de Araújo, Vera Cavalcanti</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosa, Ana Cláudia Garcia</au><au>Teixeira, Lucas Novaes</au><au>Passador-Santos, Fabricio</au><au>Furuse, Cristiane</au><au>Montalli, Victor Ângelo Martins</au><au>de Araújo, Ney Soares</au><au>de Araújo, Vera Cavalcanti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>23</volume><issue>12</issue><spage>4335</spage><epage>4343</epage><pages>4335-4343</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
This study aimed to revisit benign odontogenic ghost cell lesions (BOGCL) by hematoxylin and eosin staining and immunohistochemistry.
Materials and methods
Thirty cases of calcifying odontogenic cyst (COC) and 6 cases of dentinogenic ghost cell tumor (DGCT) were selected for histopathological and immunohistochemical analysis. Sections stained for cytokeratin (K) 14, K-19, amelogenin, collagen type 1 (COL-1), and dentin matrix acidic phosphoprotein 1 (DMP-1) were evaluated using qualitative analysis. Sections stained for Ki-67 and minichromosome maintenance protein-2 (MCM-2) were evaluated using semi-quantitative analysis.
Results
A morphologic overlap was noticed in all BOGCL. Moreover, no differences were detected in the expression of K-14 and K-19. The expression of proliferative markers Ki-67 and MCM-2 was similar between cystic and tumor lesions (
p
> .05). The presence of COL-1 and absence of amelogenin in the so-called dysplastic dentin, associated with its histologic pattern, suggest that this is in fact an enameloid-like tissue.
Conclusions
The dysplastic dentin should be considered an enameloid-like tissue in these lesions.
Clinical relevance
The similarity in histology, protein expression, and proliferative marker indices between COC and DGCT suggest that they are a sole entity and likely represent types of the same neoplasia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30911844</pmid><doi>10.1007/s00784-019-02863-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8566-3174</orcidid></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Benign Collagen Type I Cytokeratin Dental enamel Dentin Dentistry Dmp1 protein Humans Immunohistochemistry Keratins Medicine Odontogenic Cyst, Calcifying Odontogenic Tumors Original Article |
| title | Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin |
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