Interaction of C20-substituted derivative of pregnenolone acetate with copper (II) leads to ROS generation, DNA cleavage and apoptosis in cervical cancer cells: Therapeutic potential of copper chelation for cancer treatment

[Display omitted] •Pregnenolone acetate derivative (Ligand-L) inhibits growth of cervical cancer cells.•Ligand-L targets cellular copper to induce apoptosis in malignant cells.•Redox cycling of Cu(II) by ligand-L leads to ROS-mediated DNA damage.•DNA damage induces p53/p21 expression, caspase activa...

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Veröffentlicht in:	Bioorganic chemistry 2019-06, Vol.87, p.276-290
Hauptverfasser:	Zafar, Atif, Singh, Swarnendra, Ahmad, Sabahuddin, Khan, Saman, Imran Siddiqi, Mohammad, Naseem, Imrana
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Copper DNA damage Pregnenolone acetate Redox cycling Tetrazole
Online-Zugang:	Volltext
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