Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold

A new class of quinoline derivatives, bearing amino chains at C-4 and a styryl group at C-2, were tested on Leishmania donovani promastigotes and axenic and intracellular Leishmania pifanoi amastigotes. The introduction of the C-4 substituent improves the activity, which is due to interference with...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of medicinal chemistry 2019-06, Vol.171, p.38-53
Hauptverfasser:	Staderini, Matteo, Piquero, Marta, Abengózar, María Ángeles, Nachér-Vázquez, Montserrat, Romanelli, Giulia, López-Alvarado, Pilar, Rivas, Luis, Bolognesi, Maria Laura, Menéndez, J. Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Styrylquinolines 4-Aminoquinolines Leishmanicidal compounds Mitochondrial metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!