Effect of acupuncture at Neiguan point combined with amiodarone therapy on early recurrence after pulmonary vein electrical isolation in patients with persistent atrial fibrillation
Objective Early atrial fibrillation (AF) recurrences are common and have been shown to predict AF recurrences late after AF ablation during follow‐up. Neiguan point acupuncture has been recognized to be therapeutic in treating AF in clinical practice. Methods and results Eighty‐five patients were en...
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| Veröffentlicht in: | Journal of cardiovascular electrophysiology 2019-06, Vol.30 (6), p.910-917 |
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| container_title | Journal of cardiovascular electrophysiology |
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| creator | Yin, Junkui Yang, Mei Yu, Shengbo Fu, Haixia Huang, He Yang, Bo Liu, Yu He, Bo Bao, Mingwei Wu, Gang Lu, Zhibing Liu, Huangfen Liu, Xiujuan Dong, Libin Huang, Congxin Zhao, Qingyan |
| description | Objective
Early atrial fibrillation (AF) recurrences are common and have been shown to predict AF recurrences late after AF ablation during follow‐up. Neiguan point acupuncture has been recognized to be therapeutic in treating AF in clinical practice.
Methods and results
Eighty‐five patients were enrolled in succession due to persistent AF. All patients were randomized divided into control group and acupuncture group. In the control group (n = 45), amiodarone was orally taken from the first day after pulmonary vein isolation (PVI). In the acupuncture group (n = 40), patients were treated with Neiguan point acupuncture for 7 days and amiodarone was prescribed as same as the control group after PVI. The levels of inflammatory factors were analyzed before operation, 1 week after the operation and 3 months later. After 3 months, the acupuncture group had a lower rate of early recurrences than the control group (5/40 [12.5%] vs 15/45 [33.3%], P = 0.039). The inflammatory factors level in the two groups were significantly increased after ablation. However, compared with the control group, the levels of TNF‐α, IL‐6, CRP, TGF‐β1, MMP2 in the acupuncture group significantly lower (P |
| doi_str_mv | 10.1111/jce.13924 |
| format | Article |
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Early atrial fibrillation (AF) recurrences are common and have been shown to predict AF recurrences late after AF ablation during follow‐up. Neiguan point acupuncture has been recognized to be therapeutic in treating AF in clinical practice.
Methods and results
Eighty‐five patients were enrolled in succession due to persistent AF. All patients were randomized divided into control group and acupuncture group. In the control group (n = 45), amiodarone was orally taken from the first day after pulmonary vein isolation (PVI). In the acupuncture group (n = 40), patients were treated with Neiguan point acupuncture for 7 days and amiodarone was prescribed as same as the control group after PVI. The levels of inflammatory factors were analyzed before operation, 1 week after the operation and 3 months later. After 3 months, the acupuncture group had a lower rate of early recurrences than the control group (5/40 [12.5%] vs 15/45 [33.3%], P = 0.039). The inflammatory factors level in the two groups were significantly increased after ablation. However, compared with the control group, the levels of TNF‐α, IL‐6, CRP, TGF‐β1, MMP2 in the acupuncture group significantly lower (P < 0.05). In a multivariate analysis, acupuncture was an independent factor associated with a lower rate of early recurrences during the blanking period (odds ratio, 0.17; 95% confidence interval, 0.05‐0.63; P = 0.008).
Conclusion
Neiguan point acupuncture combined with amiodarone is superior to amiodarone alone in reducing early recurrences of patients with persistent AF after PVI. The efficacy of Neiguan acupuncture therapy on the early recurrence is associated with the decreased inflammation factors.</description><identifier>ISSN: 1045-3873</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1111/jce.13924</identifier><identifier>PMID: 30907035</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Ablation ; Acupuncture ; Amiodarone ; atrial fibrillation ; Blanking ; Cardiac arrhythmia ; early recurrences ; Fibrillation ; Gelatinase A ; Inflammation ; Multivariate analysis ; Neiguan point ; Patients ; Transforming growth factor-b1 ; Tumor necrosis factor</subject><ispartof>Journal of cardiovascular electrophysiology, 2019-06, Vol.30 (6), p.910-917</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-a76ba5e4bdd15935e2b09ec092a510dda746ea74818be7b6a5ec765b25a75f9c3</citedby><cites>FETCH-LOGICAL-c3534-a76ba5e4bdd15935e2b09ec092a510dda746ea74818be7b6a5ec765b25a75f9c3</cites><orcidid>0000-0002-7950-3465 ; 0000-0002-9610-2452 ; 0000-0003-2817-7863 ; 0000-0002-0814-5269</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjce.13924$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjce.13924$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30907035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Junkui</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><creatorcontrib>Yu, Shengbo</creatorcontrib><creatorcontrib>Fu, Haixia</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Yang, Bo</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>He, Bo</creatorcontrib><creatorcontrib>Bao, Mingwei</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Lu, Zhibing</creatorcontrib><creatorcontrib>Liu, Huangfen</creatorcontrib><creatorcontrib>Liu, Xiujuan</creatorcontrib><creatorcontrib>Dong, Libin</creatorcontrib><creatorcontrib>Huang, Congxin</creatorcontrib><creatorcontrib>Zhao, Qingyan</creatorcontrib><title>Effect of acupuncture at Neiguan point combined with amiodarone therapy on early recurrence after pulmonary vein electrical isolation in patients with persistent atrial fibrillation</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description>Objective
Early atrial fibrillation (AF) recurrences are common and have been shown to predict AF recurrences late after AF ablation during follow‐up. Neiguan point acupuncture has been recognized to be therapeutic in treating AF in clinical practice.
Methods and results
Eighty‐five patients were enrolled in succession due to persistent AF. All patients were randomized divided into control group and acupuncture group. In the control group (n = 45), amiodarone was orally taken from the first day after pulmonary vein isolation (PVI). In the acupuncture group (n = 40), patients were treated with Neiguan point acupuncture for 7 days and amiodarone was prescribed as same as the control group after PVI. The levels of inflammatory factors were analyzed before operation, 1 week after the operation and 3 months later. After 3 months, the acupuncture group had a lower rate of early recurrences than the control group (5/40 [12.5%] vs 15/45 [33.3%], P = 0.039). The inflammatory factors level in the two groups were significantly increased after ablation. However, compared with the control group, the levels of TNF‐α, IL‐6, CRP, TGF‐β1, MMP2 in the acupuncture group significantly lower (P < 0.05). In a multivariate analysis, acupuncture was an independent factor associated with a lower rate of early recurrences during the blanking period (odds ratio, 0.17; 95% confidence interval, 0.05‐0.63; P = 0.008).
Conclusion
Neiguan point acupuncture combined with amiodarone is superior to amiodarone alone in reducing early recurrences of patients with persistent AF after PVI. The efficacy of Neiguan acupuncture therapy on the early recurrence is associated with the decreased inflammation factors.</description><subject>Ablation</subject><subject>Acupuncture</subject><subject>Amiodarone</subject><subject>atrial fibrillation</subject><subject>Blanking</subject><subject>Cardiac arrhythmia</subject><subject>early recurrences</subject><subject>Fibrillation</subject><subject>Gelatinase A</subject><subject>Inflammation</subject><subject>Multivariate analysis</subject><subject>Neiguan point</subject><subject>Patients</subject><subject>Transforming growth factor-b1</subject><subject>Tumor necrosis factor</subject><issn>1045-3873</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kctu1TAQhiNERUthwQsgS2xgkdbXOFmio8NNVbuBdeQ4E-qjxA6-tDoPxvt1IIUFEl7Yo9Hnf37NX1WvGL1geC4PFi6Y6Lh8Up0xJWndskY_xZpKVYtWi9PqeUoHSploqHpWnQraUU2FOqt-7qcJbCZhIsaWtXibSwRiMrkG970YT9bgfCY2LIPzMJJ7l2-JWVwYTQweSL6FaNYjCZ6AifORRLAlRvAWVaYMkaxlXoI38UjuwCE147zorJmJS2E22eFX7K9Ygc9pm7BCTC5lbKCX6BCe3BDdvPEvqpPJzAlePr7n1bcP-6-7T_XVzcfPu_dXtRVKyNroZjAK5DCOTHVCAR9oB5Z23ChGx9Fo2QBeLWsH0EODrNWNGrgyWk2dFefV2013jeFHgZT7xSUL6MJDKKnnrNOCt5JxRN_8gx5CiR7d9ZxLhRSXHVLvNsrGkFKEqV-jW3A3PaP9ryx7zLL_nSWyrx8Vy7DA-Jf8Ex4Clxtw72Y4_l-p_7Lbb5IPs0itVQ</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Yin, Junkui</creator><creator>Yang, Mei</creator><creator>Yu, Shengbo</creator><creator>Fu, Haixia</creator><creator>Huang, He</creator><creator>Yang, Bo</creator><creator>Liu, Yu</creator><creator>He, Bo</creator><creator>Bao, Mingwei</creator><creator>Wu, Gang</creator><creator>Lu, Zhibing</creator><creator>Liu, Huangfen</creator><creator>Liu, Xiujuan</creator><creator>Dong, Libin</creator><creator>Huang, Congxin</creator><creator>Zhao, Qingyan</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7950-3465</orcidid><orcidid>https://orcid.org/0000-0002-9610-2452</orcidid><orcidid>https://orcid.org/0000-0003-2817-7863</orcidid><orcidid>https://orcid.org/0000-0002-0814-5269</orcidid></search><sort><creationdate>201906</creationdate><title>Effect of acupuncture at Neiguan point combined with amiodarone therapy on early recurrence after pulmonary vein electrical isolation in patients with persistent atrial fibrillation</title><author>Yin, Junkui ; Yang, Mei ; Yu, Shengbo ; Fu, Haixia ; Huang, He ; Yang, Bo ; Liu, Yu ; He, Bo ; Bao, Mingwei ; Wu, Gang ; Lu, Zhibing ; Liu, Huangfen ; Liu, Xiujuan ; Dong, Libin ; Huang, Congxin ; Zhao, Qingyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-a76ba5e4bdd15935e2b09ec092a510dda746ea74818be7b6a5ec765b25a75f9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ablation</topic><topic>Acupuncture</topic><topic>Amiodarone</topic><topic>atrial fibrillation</topic><topic>Blanking</topic><topic>Cardiac arrhythmia</topic><topic>early recurrences</topic><topic>Fibrillation</topic><topic>Gelatinase A</topic><topic>Inflammation</topic><topic>Multivariate analysis</topic><topic>Neiguan point</topic><topic>Patients</topic><topic>Transforming growth factor-b1</topic><topic>Tumor necrosis factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Junkui</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><creatorcontrib>Yu, Shengbo</creatorcontrib><creatorcontrib>Fu, Haixia</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Yang, Bo</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>He, Bo</creatorcontrib><creatorcontrib>Bao, Mingwei</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Lu, Zhibing</creatorcontrib><creatorcontrib>Liu, Huangfen</creatorcontrib><creatorcontrib>Liu, Xiujuan</creatorcontrib><creatorcontrib>Dong, Libin</creatorcontrib><creatorcontrib>Huang, Congxin</creatorcontrib><creatorcontrib>Zhao, Qingyan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Junkui</au><au>Yang, Mei</au><au>Yu, Shengbo</au><au>Fu, Haixia</au><au>Huang, He</au><au>Yang, Bo</au><au>Liu, Yu</au><au>He, Bo</au><au>Bao, Mingwei</au><au>Wu, Gang</au><au>Lu, Zhibing</au><au>Liu, Huangfen</au><au>Liu, Xiujuan</au><au>Dong, Libin</au><au>Huang, Congxin</au><au>Zhao, Qingyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of acupuncture at Neiguan point combined with amiodarone therapy on early recurrence after pulmonary vein electrical isolation in patients with persistent atrial fibrillation</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>2019-06</date><risdate>2019</risdate><volume>30</volume><issue>6</issue><spage>910</spage><epage>917</epage><pages>910-917</pages><issn>1045-3873</issn><eissn>1540-8167</eissn><abstract>Objective
Early atrial fibrillation (AF) recurrences are common and have been shown to predict AF recurrences late after AF ablation during follow‐up. Neiguan point acupuncture has been recognized to be therapeutic in treating AF in clinical practice.
Methods and results
Eighty‐five patients were enrolled in succession due to persistent AF. All patients were randomized divided into control group and acupuncture group. In the control group (n = 45), amiodarone was orally taken from the first day after pulmonary vein isolation (PVI). In the acupuncture group (n = 40), patients were treated with Neiguan point acupuncture for 7 days and amiodarone was prescribed as same as the control group after PVI. The levels of inflammatory factors were analyzed before operation, 1 week after the operation and 3 months later. After 3 months, the acupuncture group had a lower rate of early recurrences than the control group (5/40 [12.5%] vs 15/45 [33.3%], P = 0.039). The inflammatory factors level in the two groups were significantly increased after ablation. However, compared with the control group, the levels of TNF‐α, IL‐6, CRP, TGF‐β1, MMP2 in the acupuncture group significantly lower (P < 0.05). In a multivariate analysis, acupuncture was an independent factor associated with a lower rate of early recurrences during the blanking period (odds ratio, 0.17; 95% confidence interval, 0.05‐0.63; P = 0.008).
Conclusion
Neiguan point acupuncture combined with amiodarone is superior to amiodarone alone in reducing early recurrences of patients with persistent AF after PVI. The efficacy of Neiguan acupuncture therapy on the early recurrence is associated with the decreased inflammation factors.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30907035</pmid><doi>10.1111/jce.13924</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7950-3465</orcidid><orcidid>https://orcid.org/0000-0002-9610-2452</orcidid><orcidid>https://orcid.org/0000-0003-2817-7863</orcidid><orcidid>https://orcid.org/0000-0002-0814-5269</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Ablation Acupuncture Amiodarone atrial fibrillation Blanking Cardiac arrhythmia early recurrences Fibrillation Gelatinase A Inflammation Multivariate analysis Neiguan point Patients Transforming growth factor-b1 Tumor necrosis factor |
| title | Effect of acupuncture at Neiguan point combined with amiodarone therapy on early recurrence after pulmonary vein electrical isolation in patients with persistent atrial fibrillation |
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