Caspase-1 Inhibition Attenuates Hyperoxia-induced Lung and Brain Injury in Neonatal Mice

Hyperoxia plays a key role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of preterm infants. Infants with BPD often have brain injury that leads to long-term neurodevelopmental impairment, but the underlying mechanisms that control BPD-induced neurodevelopmental impa...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2019-09, Vol.61 (3), p.341-354
Hauptverfasser:	Dapaah-Siakwan, Fredrick, Zambrano, Ronald, Luo, Shihua, Duncan, Matthew R, Kerr, Nadine, Donda, Keyur, de Rivero Vaccari, Juan Pablo, Keane, Robert W, Dietrich, W Dalton, Benny, Merline, Young, Karen, Wu, Shu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Animals, Newborn Apoptosis Atrophy Brain Injuries - metabolism Brain injury Brain research Caspase Caspase 1 - metabolism Caspase-1 Cell death Cell growth Cell proliferation Cell Proliferation - physiology Clinical trials Dysplasia Humans Hyperoxia Hyperoxia - metabolism Hypertension, Pulmonary - complications IL-1β Infant, Newborn Infants Inflammasomes Inflammasomes - metabolism Inflammation Lung diseases Lung Injury - metabolism Lungs Mice Mice, Inbred C57BL Neonates Neurodevelopmental disorders Newborn babies Oxygen therapy Pathogenesis Proteins Pyroptosis Serpins - pharmacology Stem cells Studies Subventricular zone Traumatic brain injury Vascular endothelial growth factor Ventilators Viral Proteins - pharmacology
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