Patients with Plasma Cell Disorders Have High EBV DNA in Peripheral Blood than the General Population
Epstein-Barr virus (EBV) is involved in the development of a wide range of B cell lympho-proliferative disorders. Its association with plasma cell disorders (PCD) however is not clear, especially in immunocompetent patients. To explore any relationship, 39 patients of suspected PCD with positive M-b...
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| Veröffentlicht in: | Pathology oncology research 2020-10, Vol.26 (4), p.2789-2794 |
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| creator | Sangam, Kumar Kumar, Yashwant Minz, Ranjana Walker Varma, Neelam Varma, Subhash Anand, Shashi |
| description | Epstein-Barr virus (EBV) is involved in the development of a wide range of B cell lympho-proliferative disorders. Its association with plasma cell disorders (PCD) however is not clear, especially in immunocompetent patients. To explore any relationship, 39 patients of suspected PCD with positive M-band on electrophoresis and 50 healthy controls were enrolled. EBV DNA in peripheral blood was quantified using quantitative Real Time Polymerase Chain Reaction (qPCR). Of 39 patients, 15 (38.5%) had EBV DNA compared to 8/50 (16%) controls (
p = 0.0008
). The mean viral copy number was found to be significantly high in patients compared to controls (1.8 × 10
5
; range = 2.6 × 10
3
–7.6 × 10
5
copies/ml and 1.7 × 10
4
; range = 7.0 × 10
2
–6.1 × 10
4
copies/ml respectively;
p = 0.003
). This is the first study, which characterizes the frequency of EBV in circulation in patients of PCD. The significance of increased prevalence of circulating EBV and a higher viral load in our immunocompetent patients however, needs further evaluation. |
| doi_str_mv | 10.1007/s12253-019-00640-1 |
| format | Article |
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p = 0.0008
). The mean viral copy number was found to be significantly high in patients compared to controls (1.8 × 10
5
; range = 2.6 × 10
3
–7.6 × 10
5
copies/ml and 1.7 × 10
4
; range = 7.0 × 10
2
–6.1 × 10
4
copies/ml respectively;
p = 0.003
). This is the first study, which characterizes the frequency of EBV in circulation in patients of PCD. The significance of increased prevalence of circulating EBV and a higher viral load in our immunocompetent patients however, needs further evaluation.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-019-00640-1</identifier><identifier>PMID: 30900081</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Copy number ; Deoxyribonucleic acid ; DNA ; Electrophoresis ; Epstein-Barr virus ; Immunocompetence ; Immunology ; Lymphocytes B ; Oncology ; Pathology ; Peripheral blood ; Polymerase chain reaction ; Short Communication</subject><ispartof>Pathology oncology research, 2020-10, Vol.26 (4), p.2789-2794</ispartof><rights>Arányi Lajos Foundation 2019</rights><rights>Pathology & Oncology Research is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>Arányi Lajos Foundation 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-392719ce9c59c2f258faac38ad5b8dd9721841a16f4faac3a5c87090690033d43</citedby><cites>FETCH-LOGICAL-c403t-392719ce9c59c2f258faac38ad5b8dd9721841a16f4faac3a5c87090690033d43</cites><orcidid>0000-0001-6369-3834</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-019-00640-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-019-00640-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30900081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sangam, Kumar</creatorcontrib><creatorcontrib>Kumar, Yashwant</creatorcontrib><creatorcontrib>Minz, Ranjana Walker</creatorcontrib><creatorcontrib>Varma, Neelam</creatorcontrib><creatorcontrib>Varma, Subhash</creatorcontrib><creatorcontrib>Anand, Shashi</creatorcontrib><title>Patients with Plasma Cell Disorders Have High EBV DNA in Peripheral Blood than the General Population</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>Epstein-Barr virus (EBV) is involved in the development of a wide range of B cell lympho-proliferative disorders. Its association with plasma cell disorders (PCD) however is not clear, especially in immunocompetent patients. To explore any relationship, 39 patients of suspected PCD with positive M-band on electrophoresis and 50 healthy controls were enrolled. EBV DNA in peripheral blood was quantified using quantitative Real Time Polymerase Chain Reaction (qPCR). Of 39 patients, 15 (38.5%) had EBV DNA compared to 8/50 (16%) controls (
p = 0.0008
). The mean viral copy number was found to be significantly high in patients compared to controls (1.8 × 10
5
; range = 2.6 × 10
3
–7.6 × 10
5
copies/ml and 1.7 × 10
4
; range = 7.0 × 10
2
–6.1 × 10
4
copies/ml respectively;
p = 0.003
). This is the first study, which characterizes the frequency of EBV in circulation in patients of PCD. The significance of increased prevalence of circulating EBV and a higher viral load in our immunocompetent patients however, needs further evaluation.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Copy number</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Electrophoresis</subject><subject>Epstein-Barr virus</subject><subject>Immunocompetence</subject><subject>Immunology</subject><subject>Lymphocytes B</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Peripheral blood</subject><subject>Polymerase chain reaction</subject><subject>Short Communication</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kblOxDAQhi0E4n4BCmSJhibgM4nLvWCRVpACaC2TOCSrbLzYCYi3Z9hwSBQ0tsfzze8Z_widUHJBCUkuA2VM8ohQFRESCxLRLbRPJWcRS0myDWcGKaFkvIcOQlgSKIpVvIv2OFEQpHQf2cx0tW27gN_qrsJZY8LK4IltGjytg_OF9QHPzavF8_q5wrPxI57ejnDd4sz6el1Zbxo8bpwrcFeZFhaLr227uc7cum9A3rVHaKc0TbDHX_sheria3U_m0eLu-mYyWkS5ILyLuGIJVblVuVQ5K5lMS2NynppCPqVFoRJGU0ENjUuxSRiZpwmMEsM0nBeCH6LzQXft3UtvQ6dXdchhGNNa1wcN_xFLJqlkgJ79QZeu9y10p5kQhLA4FepfiiqhEmiZAMUGKvcuBG9Lvfb1yvh3TYn-tEoPVmmwSm-s0hSKTr-k-6eVLX5Kvr0BgA9AgFT7bP3v2__IfgBITZtg</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Sangam, Kumar</creator><creator>Kumar, Yashwant</creator><creator>Minz, Ranjana Walker</creator><creator>Varma, Neelam</creator><creator>Varma, Subhash</creator><creator>Anand, Shashi</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6369-3834</orcidid></search><sort><creationdate>20201001</creationdate><title>Patients with Plasma Cell Disorders Have High EBV DNA in Peripheral Blood than the General Population</title><author>Sangam, Kumar ; Kumar, Yashwant ; Minz, Ranjana Walker ; Varma, Neelam ; Varma, Subhash ; Anand, Shashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-392719ce9c59c2f258faac38ad5b8dd9721841a16f4faac3a5c87090690033d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Copy number</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Electrophoresis</topic><topic>Epstein-Barr virus</topic><topic>Immunocompetence</topic><topic>Immunology</topic><topic>Lymphocytes B</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Peripheral blood</topic><topic>Polymerase chain reaction</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sangam, Kumar</creatorcontrib><creatorcontrib>Kumar, Yashwant</creatorcontrib><creatorcontrib>Minz, Ranjana Walker</creatorcontrib><creatorcontrib>Varma, Neelam</creatorcontrib><creatorcontrib>Varma, Subhash</creatorcontrib><creatorcontrib>Anand, Shashi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sangam, Kumar</au><au>Kumar, Yashwant</au><au>Minz, Ranjana Walker</au><au>Varma, Neelam</au><au>Varma, Subhash</au><au>Anand, Shashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patients with Plasma Cell Disorders Have High EBV DNA in Peripheral Blood than the General Population</atitle><jtitle>Pathology oncology research</jtitle><stitle>Pathol. Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>26</volume><issue>4</issue><spage>2789</spage><epage>2794</epage><pages>2789-2794</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>Epstein-Barr virus (EBV) is involved in the development of a wide range of B cell lympho-proliferative disorders. Its association with plasma cell disorders (PCD) however is not clear, especially in immunocompetent patients. To explore any relationship, 39 patients of suspected PCD with positive M-band on electrophoresis and 50 healthy controls were enrolled. EBV DNA in peripheral blood was quantified using quantitative Real Time Polymerase Chain Reaction (qPCR). Of 39 patients, 15 (38.5%) had EBV DNA compared to 8/50 (16%) controls (
p = 0.0008
). The mean viral copy number was found to be significantly high in patients compared to controls (1.8 × 10
5
; range = 2.6 × 10
3
–7.6 × 10
5
copies/ml and 1.7 × 10
4
; range = 7.0 × 10
2
–6.1 × 10
4
copies/ml respectively;
p = 0.003
). This is the first study, which characterizes the frequency of EBV in circulation in patients of PCD. The significance of increased prevalence of circulating EBV and a higher viral load in our immunocompetent patients however, needs further evaluation.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>30900081</pmid><doi>10.1007/s12253-019-00640-1</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6369-3834</orcidid></addata></record> |
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| language | eng |
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| subjects | Biomedical and Life Sciences Biomedicine Cancer Research Copy number Deoxyribonucleic acid DNA Electrophoresis Epstein-Barr virus Immunocompetence Immunology Lymphocytes B Oncology Pathology Peripheral blood Polymerase chain reaction Short Communication |
| title | Patients with Plasma Cell Disorders Have High EBV DNA in Peripheral Blood than the General Population |
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