Determinants of neurodevelopment in early childhood – results from the Copenhagen prospective studies on asthma in childhood (COPSAC2010) mother–child cohort
Aim The objective of this study was to identify possible pre‐ and postnatal factors influencing neurodevelopment of the young child. Methods We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort, but excluded those with a neurological diagn...
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| Veröffentlicht in: | Acta Paediatrica 2019-09, Vol.108 (9), p.1632-1641 |
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| container_title | Acta Paediatrica |
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| creator | Bjarnadóttir, Elín Stokholm, Jakob Chawes, Bo Thorsen, Jonathan Mora‐Jensen, Anna‐Rosa Cecilie Deleuran, Maja Bønnelykke, Klaus Lauritzen, Lotte Bisgaard, Hans |
| description | Aim
The objective of this study was to identify possible pre‐ and postnatal factors influencing neurodevelopment of the young child.
Methods
We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort, but excluded those with a neurological diagnosis, born |
| doi_str_mv | 10.1111/apa.14753 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2196518425</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2196518425</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3883-dafdcefe9c89b9ea1d17e1334b0db16d11b32202f05dd57569677d37533387053</originalsourceid><addsrcrecordid>eNp1kctq3DAUhkVpaabTLvICRdBNsnCii21Zy8HpDQIJJF0L2TqOHWzJleSE2fUd8gR5tT5JNZm0hUK10eJ85-Pw_wgdUnJC0zvVsz6huSj4C7SiZUEzxph4iVakIjwrWMEP0JsQbglhXObla3TAicjTrFyhxzOI4KfBahsDdh22sHhn4A5GN09gIx4sBu3HLW77YTS9cwb__PGAPYRlTCuddxOOPeDazWB7fQMWz96FGdo43AEOcTEDJLXFOsR-0jvhX9VRfXF5takZoeQYTy6JfLI_zXHreufjW_Sq02OAd8__Gn379PG6_pKdX3z-Wm_Os5ZXFc-M7kwLHci2ko0ETQ0VQDnPG2IaWhpKG84YYR0pjClEUcpSCMNTaJxXghR8jY723nT99wVCVNMQWhhHbcEtQTEqU7RVznboh3_QW7d4m65TjJVScCnTSWt0vKfaFEfw0KnZD5P2W0WJ2vWmUm_qqbfEvn82Ls0E5g_5u6gEnO6B-2GE7f9NanO52St_AZrlpJM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2269739988</pqid></control><display><type>article</type><title>Determinants of neurodevelopment in early childhood – results from the Copenhagen prospective studies on asthma in childhood (COPSAC2010) mother–child cohort</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Bjarnadóttir, Elín ; Stokholm, Jakob ; Chawes, Bo ; Thorsen, Jonathan ; Mora‐Jensen, Anna‐Rosa Cecilie ; Deleuran, Maja ; Bønnelykke, Klaus ; Lauritzen, Lotte ; Bisgaard, Hans</creator><creatorcontrib>Bjarnadóttir, Elín ; Stokholm, Jakob ; Chawes, Bo ; Thorsen, Jonathan ; Mora‐Jensen, Anna‐Rosa Cecilie ; Deleuran, Maja ; Bønnelykke, Klaus ; Lauritzen, Lotte ; Bisgaard, Hans</creatorcontrib><description>Aim
The objective of this study was to identify possible pre‐ and postnatal factors influencing neurodevelopment of the young child.
Methods
We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birthweights <2500 g, resulting in 650 children analysed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.
Results
Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema and number of sick days (p > 0.05 in all tests). Early age at milestone achievement was associated with male sex (p = 0.05), lower maternal age (p = 0.02), higher gestational age (p < 0.001) and paternity leave (p = 0.01). A higher 1‐year language score was associated with female sex (p = 0.02) and maternal smoking during pregnancy (p = 0.01) and a higher 2‐year language score with female sex (p < 0.001) and being first born (p = 0.01). A higher cognitive score was associated with female sex (p = 0.02).
Conclusion
Neurodevelopmental scores were unrelated to breastfeeding, persistent wheeze, eczema and number of sick days. Neurodevelopment in early childhood was mostly associated with gender.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.14753</identifier><identifier>PMID: 30748036</identifier><language>eng</language><publisher>Norway: Wiley Subscription Services, Inc</publisher><subject>Age ; Asthma ; Breast feeding ; Breastfeeding & lactation ; Childhood ; Children ; Cognitive ability ; Cognitive development ; Eczema ; Gender ; Gestation ; Gestational age ; Language ; Language development ; Maternity & paternity leaves ; Motor development ; Neurodevelopment ; Neurological development ; Paternity ; Pregnancy ; Sex ; Skin diseases ; Smoking</subject><ispartof>Acta Paediatrica, 2019-09, Vol.108 (9), p.1632-1641</ispartof><rights>2019 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><rights>2019 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-dafdcefe9c89b9ea1d17e1334b0db16d11b32202f05dd57569677d37533387053</citedby><cites>FETCH-LOGICAL-c3883-dafdcefe9c89b9ea1d17e1334b0db16d11b32202f05dd57569677d37533387053</cites><orcidid>0000-0003-4131-7592</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.14753$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.14753$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30748036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bjarnadóttir, Elín</creatorcontrib><creatorcontrib>Stokholm, Jakob</creatorcontrib><creatorcontrib>Chawes, Bo</creatorcontrib><creatorcontrib>Thorsen, Jonathan</creatorcontrib><creatorcontrib>Mora‐Jensen, Anna‐Rosa Cecilie</creatorcontrib><creatorcontrib>Deleuran, Maja</creatorcontrib><creatorcontrib>Bønnelykke, Klaus</creatorcontrib><creatorcontrib>Lauritzen, Lotte</creatorcontrib><creatorcontrib>Bisgaard, Hans</creatorcontrib><title>Determinants of neurodevelopment in early childhood – results from the Copenhagen prospective studies on asthma in childhood (COPSAC2010) mother–child cohort</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim
The objective of this study was to identify possible pre‐ and postnatal factors influencing neurodevelopment of the young child.
Methods
We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birthweights <2500 g, resulting in 650 children analysed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.
Results
Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema and number of sick days (p > 0.05 in all tests). Early age at milestone achievement was associated with male sex (p = 0.05), lower maternal age (p = 0.02), higher gestational age (p < 0.001) and paternity leave (p = 0.01). A higher 1‐year language score was associated with female sex (p = 0.02) and maternal smoking during pregnancy (p = 0.01) and a higher 2‐year language score with female sex (p < 0.001) and being first born (p = 0.01). A higher cognitive score was associated with female sex (p = 0.02).
Conclusion
Neurodevelopmental scores were unrelated to breastfeeding, persistent wheeze, eczema and number of sick days. Neurodevelopment in early childhood was mostly associated with gender.</description><subject>Age</subject><subject>Asthma</subject><subject>Breast feeding</subject><subject>Breastfeeding & lactation</subject><subject>Childhood</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Cognitive development</subject><subject>Eczema</subject><subject>Gender</subject><subject>Gestation</subject><subject>Gestational age</subject><subject>Language</subject><subject>Language development</subject><subject>Maternity & paternity leaves</subject><subject>Motor development</subject><subject>Neurodevelopment</subject><subject>Neurological development</subject><subject>Paternity</subject><subject>Pregnancy</subject><subject>Sex</subject><subject>Skin diseases</subject><subject>Smoking</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kctq3DAUhkVpaabTLvICRdBNsnCii21Zy8HpDQIJJF0L2TqOHWzJleSE2fUd8gR5tT5JNZm0hUK10eJ85-Pw_wgdUnJC0zvVsz6huSj4C7SiZUEzxph4iVakIjwrWMEP0JsQbglhXObla3TAicjTrFyhxzOI4KfBahsDdh22sHhn4A5GN09gIx4sBu3HLW77YTS9cwb__PGAPYRlTCuddxOOPeDazWB7fQMWz96FGdo43AEOcTEDJLXFOsR-0jvhX9VRfXF5takZoeQYTy6JfLI_zXHreufjW_Sq02OAd8__Gn379PG6_pKdX3z-Wm_Os5ZXFc-M7kwLHci2ko0ETQ0VQDnPG2IaWhpKG84YYR0pjClEUcpSCMNTaJxXghR8jY723nT99wVCVNMQWhhHbcEtQTEqU7RVznboh3_QW7d4m65TjJVScCnTSWt0vKfaFEfw0KnZD5P2W0WJ2vWmUm_qqbfEvn82Ls0E5g_5u6gEnO6B-2GE7f9NanO52St_AZrlpJM</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Bjarnadóttir, Elín</creator><creator>Stokholm, Jakob</creator><creator>Chawes, Bo</creator><creator>Thorsen, Jonathan</creator><creator>Mora‐Jensen, Anna‐Rosa Cecilie</creator><creator>Deleuran, Maja</creator><creator>Bønnelykke, Klaus</creator><creator>Lauritzen, Lotte</creator><creator>Bisgaard, Hans</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4131-7592</orcidid></search><sort><creationdate>201909</creationdate><title>Determinants of neurodevelopment in early childhood – results from the Copenhagen prospective studies on asthma in childhood (COPSAC2010) mother–child cohort</title><author>Bjarnadóttir, Elín ; Stokholm, Jakob ; Chawes, Bo ; Thorsen, Jonathan ; Mora‐Jensen, Anna‐Rosa Cecilie ; Deleuran, Maja ; Bønnelykke, Klaus ; Lauritzen, Lotte ; Bisgaard, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-dafdcefe9c89b9ea1d17e1334b0db16d11b32202f05dd57569677d37533387053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Asthma</topic><topic>Breast feeding</topic><topic>Breastfeeding & lactation</topic><topic>Childhood</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Cognitive development</topic><topic>Eczema</topic><topic>Gender</topic><topic>Gestation</topic><topic>Gestational age</topic><topic>Language</topic><topic>Language development</topic><topic>Maternity & paternity leaves</topic><topic>Motor development</topic><topic>Neurodevelopment</topic><topic>Neurological development</topic><topic>Paternity</topic><topic>Pregnancy</topic><topic>Sex</topic><topic>Skin diseases</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bjarnadóttir, Elín</creatorcontrib><creatorcontrib>Stokholm, Jakob</creatorcontrib><creatorcontrib>Chawes, Bo</creatorcontrib><creatorcontrib>Thorsen, Jonathan</creatorcontrib><creatorcontrib>Mora‐Jensen, Anna‐Rosa Cecilie</creatorcontrib><creatorcontrib>Deleuran, Maja</creatorcontrib><creatorcontrib>Bønnelykke, Klaus</creatorcontrib><creatorcontrib>Lauritzen, Lotte</creatorcontrib><creatorcontrib>Bisgaard, Hans</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bjarnadóttir, Elín</au><au>Stokholm, Jakob</au><au>Chawes, Bo</au><au>Thorsen, Jonathan</au><au>Mora‐Jensen, Anna‐Rosa Cecilie</au><au>Deleuran, Maja</au><au>Bønnelykke, Klaus</au><au>Lauritzen, Lotte</au><au>Bisgaard, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of neurodevelopment in early childhood – results from the Copenhagen prospective studies on asthma in childhood (COPSAC2010) mother–child cohort</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2019-09</date><risdate>2019</risdate><volume>108</volume><issue>9</issue><spage>1632</spage><epage>1641</epage><pages>1632-1641</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim
The objective of this study was to identify possible pre‐ and postnatal factors influencing neurodevelopment of the young child.
Methods
We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birthweights <2500 g, resulting in 650 children analysed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.
Results
Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema and number of sick days (p > 0.05 in all tests). Early age at milestone achievement was associated with male sex (p = 0.05), lower maternal age (p = 0.02), higher gestational age (p < 0.001) and paternity leave (p = 0.01). A higher 1‐year language score was associated with female sex (p = 0.02) and maternal smoking during pregnancy (p = 0.01) and a higher 2‐year language score with female sex (p < 0.001) and being first born (p = 0.01). A higher cognitive score was associated with female sex (p = 0.02).
Conclusion
Neurodevelopmental scores were unrelated to breastfeeding, persistent wheeze, eczema and number of sick days. Neurodevelopment in early childhood was mostly associated with gender.</abstract><cop>Norway</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30748036</pmid><doi>10.1111/apa.14753</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4131-7592</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta Paediatrica, 2019-09, Vol.108 (9), p.1632-1641 |
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| source | Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Age Asthma Breast feeding Breastfeeding & lactation Childhood Children Cognitive ability Cognitive development Eczema Gender Gestation Gestational age Language Language development Maternity & paternity leaves Motor development Neurodevelopment Neurological development Paternity Pregnancy Sex Skin diseases Smoking |
| title | Determinants of neurodevelopment in early childhood – results from the Copenhagen prospective studies on asthma in childhood (COPSAC2010) mother–child cohort |
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