Rosette-forming and papillary glioneuronal tumors - A clinicopathological and molecular analysis
Rosette-forming glioneuronal tumors (RGNT) and papillary glioneuronal tumors (PGNT) account for < 1% of brain tumors. Genetic data regarding RGNT and PGNT is still evolving. We aimed to perform a detailed clinicopathological analysis on rosette-forming and papillary glioneuronal tumors and to eva...
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| Veröffentlicht in: | Clinical neuropathology 2019-07, Vol.38 (4), p.180-188 |
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| creator | Singh, Vikram Gupta, Kirti Salunke, Pravin Kumar, Sandeep Radotra, Bishan Dass Vasishta, Rakesh Kumar |
| description | Rosette-forming glioneuronal tumors (RGNT) and papillary glioneuronal tumors (PGNT) account for < 1% of brain tumors. Genetic data regarding RGNT and PGNT is still evolving. We aimed to perform a detailed clinicopathological analysis on rosette-forming and papillary glioneuronal tumors and to evaluate these for common, known genetic mutations.
Our cohort consisted of 6 cases of these rare glioneuronal tumors diagnosed over a period of 5 years. IDH1, ATRX, p53, and BRAF V600E mutations were evaluated on immunohistochemistry, and cases of RGNT were screened for the mutations in
gene at hotspots exon 4, 9, and 20.
Our findings confirm the presence of
gene mutations in RGNT along with two novel mutations in
gene, of which one is proposed to be of prognostic significance.
. |
| doi_str_mv | 10.5414/NP301164 |
| format | Article |
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Our cohort consisted of 6 cases of these rare glioneuronal tumors diagnosed over a period of 5 years. IDH1, ATRX, p53, and BRAF V600E mutations were evaluated on immunohistochemistry, and cases of RGNT were screened for the mutations in
gene at hotspots exon 4, 9, and 20.
Our findings confirm the presence of
gene mutations in RGNT along with two novel mutations in
gene, of which one is proposed to be of prognostic significance.
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Our cohort consisted of 6 cases of these rare glioneuronal tumors diagnosed over a period of 5 years. IDH1, ATRX, p53, and BRAF V600E mutations were evaluated on immunohistochemistry, and cases of RGNT were screened for the mutations in
gene at hotspots exon 4, 9, and 20.
Our findings confirm the presence of
gene mutations in RGNT along with two novel mutations in
gene, of which one is proposed to be of prognostic significance.
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Genetic data regarding RGNT and PGNT is still evolving. We aimed to perform a detailed clinicopathological analysis on rosette-forming and papillary glioneuronal tumors and to evaluate these for common, known genetic mutations.
Our cohort consisted of 6 cases of these rare glioneuronal tumors diagnosed over a period of 5 years. IDH1, ATRX, p53, and BRAF V600E mutations were evaluated on immunohistochemistry, and cases of RGNT were screened for the mutations in
gene at hotspots exon 4, 9, and 20.
Our findings confirm the presence of
gene mutations in RGNT along with two novel mutations in
gene, of which one is proposed to be of prognostic significance.
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| subjects | Adult Age Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - pathology Central Nervous System Neoplasms - diagnosis Central Nervous System Neoplasms - pathology Cerebral Ventricle Neoplasms - diagnosis Cerebral Ventricle Neoplasms - pathology Female Histopathology Humans Immunohistochemistry - methods Male Medical education Morphology Mutation Mutation - genetics Neoplasms, Neuroepithelial - diagnosis Neoplasms, Neuroepithelial - pathology Pathology, Molecular - methods Prognosis Rosette Formation - methods Tumors Young Adult |
| title | Rosette-forming and papillary glioneuronal tumors - A clinicopathological and molecular analysis |
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