Downregulation of cytokeratin 18 enhances BCRP-mediated multidrug resistance through induction of epithelial-mesenchymal transition and predicts poor prognosis in breast cancer

Multiple drug resistance (MDR) and metastasis have been identified as the two major causes of the poor prognosis of patients with breast cancer. However, the relationship between MDR and metastasis has not been characterized. Epithelial‑mesenchymal transition (EMT), a process known to promote metast...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncology reports 2019-05, Vol.41 (5), p.3015-3026
Hauptverfasser:	Shi, Ruizan, Wang, Chang, Fu, Naijie, Liu, Linhong, Zhu, Diying, Wei, Zehui, Zhang, Huifeng, Xing, Jianfeng, Wang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Binding sites Breast - pathology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer cells Cancer metastasis Cancer patients Cancer research Cell adhesion & migration Cell cycle Cell Line, Tumor Cellular signal transduction Chemotherapy Committees Cytotoxicity Development and progression Down-Regulation Drug resistance Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Drug therapy Epithelial-Mesenchymal Transition - genetics Ethics Family medical history Female Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic aspects Genetic regulation Humans Keratin Keratin-18 - genetics Keratin-18 - metabolism Lymphatic Metastasis - genetics Lymphatic Metastasis - pathology Lymphatic system Medical prognosis Metastasis Microbial drug resistance Middle Aged Mitoxantrone - pharmacology Mitoxantrone - therapeutic use Morphology Multidrug resistant organisms Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Novels Prognosis RNA, Small Interfering - metabolism Standard deviation Stem cells Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!