High prevalence of dyslipidemia and high atherogenic index of plasma in children and adolescents
Dyslipidemias in childhood increase the risk of cardiovascular events in adult life. To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents. Cross-sectional study of 208 children aged 10.4 ±...
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| Veröffentlicht in: | Revista medíca de Chile 2018-12, Vol.146 (10), p.1112-1122 |
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| container_title | Revista medíca de Chile |
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| creator | Sapunar, Jorge Aguilar-Farías, Nicolás Navarro, Juan Araneda, Gustavo Chandía-Poblete, Damian Manríquez, Víctor Brito, Roberto Cerda, Álvaro |
| description | Dyslipidemias in childhood increase the risk of cardiovascular events in adult life.
To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents.
Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low: AIP < 0.11, intermediate: AIP 0.11-0.21, high: AIP > 0.21).
Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP.
There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance. |
| doi_str_mv | 10.4067/S0034-98872018001001112 |
| format | Article |
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To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents.
Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low: AIP < 0.11, intermediate: AIP 0.11-0.21, high: AIP > 0.21).
Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP.
There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance.</description><identifier>EISSN: 0717-6163</identifier><identifier>DOI: 10.4067/S0034-98872018001001112</identifier><identifier>PMID: 30724974</identifier><language>spa</language><publisher>Chile</publisher><subject>Analysis of Variance ; Anthropometry ; Atherosclerosis - blood ; Blood Glucose - analysis ; Cardiovascular Diseases - etiology ; Child ; Chile - epidemiology ; Cholesterol - blood ; Cross-Sectional Studies ; Dyslipidemias - blood ; Dyslipidemias - complications ; Dyslipidemias - epidemiology ; Female ; Humans ; Insulin Resistance ; Logistic Models ; Male ; Nutritional Status ; Obesity, Abdominal - blood ; Prevalence ; Reference Values ; Risk Assessment ; Risk Factors ; Sex Distribution ; Sex Factors ; Socioeconomic Factors ; Statistics, Nonparametric ; Triglycerides - blood</subject><ispartof>Revista medíca de Chile, 2018-12, Vol.146 (10), p.1112-1122</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c195t-cca94a0db55f22e7f7874ac45524486cb079bcf0e2edd58d0a006bafa6361f503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30724974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sapunar, Jorge</creatorcontrib><creatorcontrib>Aguilar-Farías, Nicolás</creatorcontrib><creatorcontrib>Navarro, Juan</creatorcontrib><creatorcontrib>Araneda, Gustavo</creatorcontrib><creatorcontrib>Chandía-Poblete, Damian</creatorcontrib><creatorcontrib>Manríquez, Víctor</creatorcontrib><creatorcontrib>Brito, Roberto</creatorcontrib><creatorcontrib>Cerda, Álvaro</creatorcontrib><title>High prevalence of dyslipidemia and high atherogenic index of plasma in children and adolescents</title><title>Revista medíca de Chile</title><addtitle>Rev Med Chil</addtitle><description>Dyslipidemias in childhood increase the risk of cardiovascular events in adult life.
To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents.
Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low: AIP < 0.11, intermediate: AIP 0.11-0.21, high: AIP > 0.21).
Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP.
There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance.</description><subject>Analysis of Variance</subject><subject>Anthropometry</subject><subject>Atherosclerosis - blood</subject><subject>Blood Glucose - analysis</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Child</subject><subject>Chile - epidemiology</subject><subject>Cholesterol - blood</subject><subject>Cross-Sectional Studies</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - complications</subject><subject>Dyslipidemias - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Nutritional Status</subject><subject>Obesity, Abdominal - blood</subject><subject>Prevalence</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Socioeconomic Factors</subject><subject>Statistics, Nonparametric</subject><subject>Triglycerides - blood</subject><issn>0717-6163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kFtLw0AQhRdBbK3-Bc2jL9HZzd7yKEWtUPBBfY6T3Um7kpvZVOy_N2qFgWHgO3MOh7FLDtcStLl5BshkmltrBHALwKfhXByxORhuUs11NmOnMb4DCKO5PWGzDIyQuZFz9rYKm23SD_SJNbWOkq5K_D7WoQ-emoAJtj7Z_jA4bmnoNtQGl4TW09cP2tcYG5zuxG1D7QdqfwXou5qio3aMZ-y4wjrS-WEv2Ov93ctyla6fHh6Xt-vU8VyNqXOYSwRfKlUJQaYy1kh0UikhpdWuBJOXrgIS5L2yHhBAl1ihzjSvFGQLdvX3tx-6jx3FsWjClKCusaVuFwsx2QilrNATenFAd2VDvuiH0OCwL_5byb4BjZ1kpA</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Sapunar, Jorge</creator><creator>Aguilar-Farías, Nicolás</creator><creator>Navarro, Juan</creator><creator>Araneda, Gustavo</creator><creator>Chandía-Poblete, Damian</creator><creator>Manríquez, Víctor</creator><creator>Brito, Roberto</creator><creator>Cerda, Álvaro</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>High prevalence of dyslipidemia and high atherogenic index of plasma in children and adolescents</title><author>Sapunar, Jorge ; Aguilar-Farías, Nicolás ; Navarro, Juan ; Araneda, Gustavo ; Chandía-Poblete, Damian ; Manríquez, Víctor ; Brito, Roberto ; Cerda, Álvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c195t-cca94a0db55f22e7f7874ac45524486cb079bcf0e2edd58d0a006bafa6361f503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2018</creationdate><topic>Analysis of Variance</topic><topic>Anthropometry</topic><topic>Atherosclerosis - blood</topic><topic>Blood Glucose - analysis</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Child</topic><topic>Chile - epidemiology</topic><topic>Cholesterol - blood</topic><topic>Cross-Sectional Studies</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - complications</topic><topic>Dyslipidemias - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Nutritional Status</topic><topic>Obesity, Abdominal - blood</topic><topic>Prevalence</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Sex Factors</topic><topic>Socioeconomic Factors</topic><topic>Statistics, Nonparametric</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sapunar, Jorge</creatorcontrib><creatorcontrib>Aguilar-Farías, Nicolás</creatorcontrib><creatorcontrib>Navarro, Juan</creatorcontrib><creatorcontrib>Araneda, Gustavo</creatorcontrib><creatorcontrib>Chandía-Poblete, Damian</creatorcontrib><creatorcontrib>Manríquez, Víctor</creatorcontrib><creatorcontrib>Brito, Roberto</creatorcontrib><creatorcontrib>Cerda, Álvaro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista medíca de Chile</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sapunar, Jorge</au><au>Aguilar-Farías, Nicolás</au><au>Navarro, Juan</au><au>Araneda, Gustavo</au><au>Chandía-Poblete, Damian</au><au>Manríquez, Víctor</au><au>Brito, Roberto</au><au>Cerda, Álvaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of dyslipidemia and high atherogenic index of plasma in children and adolescents</atitle><jtitle>Revista medíca de Chile</jtitle><addtitle>Rev Med Chil</addtitle><date>2018-12</date><risdate>2018</risdate><volume>146</volume><issue>10</issue><spage>1112</spage><epage>1122</epage><pages>1112-1122</pages><eissn>0717-6163</eissn><abstract>Dyslipidemias in childhood increase the risk of cardiovascular events in adult life.
To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents.
Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low: AIP < 0.11, intermediate: AIP 0.11-0.21, high: AIP > 0.21).
Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP.
There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance.</abstract><cop>Chile</cop><pmid>30724974</pmid><doi>10.4067/S0034-98872018001001112</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis of Variance Anthropometry Atherosclerosis - blood Blood Glucose - analysis Cardiovascular Diseases - etiology Child Chile - epidemiology Cholesterol - blood Cross-Sectional Studies Dyslipidemias - blood Dyslipidemias - complications Dyslipidemias - epidemiology Female Humans Insulin Resistance Logistic Models Male Nutritional Status Obesity, Abdominal - blood Prevalence Reference Values Risk Assessment Risk Factors Sex Distribution Sex Factors Socioeconomic Factors Statistics, Nonparametric Triglycerides - blood |
| title | High prevalence of dyslipidemia and high atherogenic index of plasma in children and adolescents |
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