Direct targeting of Gαq and Gα11 oncoproteins in cancer cells

Targeting uveal melanomaUveal melanoma (UM) is a common cancer of the eye, and about half of patients with UM develop metastatic disease. Although most cases of UM are driven by constitutively active mutants of the G protein α subunits Gαq and Gα11, therapies that target signaling pathways downstrea...

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Veröffentlicht in:	Science signaling 2019-03, Vol.12 (573)
Hauptverfasser:	Annala Suvi, Feng Xiaodong, Shridhar Naveen, Eryilmaz Funda, Patt, Julian, Yang JuHee, Pfeil, Eva M, Cervantes-Villagrana Rodolfo Daniel, Inoue Asuka, Häberlein Felix, Slodczyk Tanja, Reher Raphael, Kehraus Stefan, Monteleone Stefania, Schrage Ramona, Heycke Nina, Rick, Ulrike, Engel, Sandra, Pfeifer, Alexander, Kolb, Peter, König Gabriele, Bünemann Moritz, Tüting, Thomas, Vázquez-Prado José, Silvio, Gutkind J, Gaffal Evelyn, Kostenis Evi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell culture Cell proliferation Guanosine Guanosine triphosphatases Guanosine triphosphate Melanoma Metabolic pathways Metastases Mutants Mutation Oncoproteins Patients Phospholipase Phospholipase C Proteins Radiation Signal transduction Signaling Surgery Tumors Xenografts Xenotransplantation
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