Targeting Tumor-Associated Macrophages in Cancer

Macrophages are phagocytes that serve as a first line of defense against pathogenic insults to tissues. These innate immune cells mount proinflammatory responses to pathogens and repair damaged tissues. However, tumor-associated macrophages (TAMs) express cytokines and chemokines that can suppress a...

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Veröffentlicht in:	Trends in immunology 2019-04, Vol.40 (4), p.310-327
Hauptverfasser:	Pathria, Paulina, Louis, Tiani L., Varner, Judith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Breast cancer Cancer Cancer therapies Cell activation Chemical compounds Chemokines Chemotherapy Clinical trials Cytokines Cytotoxicity Granulocytes Growth factors Immune checkpoint Immune system Immunoglobulins Immunotherapy Inflammation Lymphocytes Lymphocytes T Macrophages Medical prognosis Medical research Melanoma Metabolism Metastasis Pancreatic cancer Phagocytes Phagocytosis Pharmaceuticals Pharmacology Polarization Prostate cancer Radiation Radiation therapy repolarization Signal transduction Synergism T cell receptors Tissues trafficking Tumors
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