A Prospective Study of Presepsin as an Indicator of the Severity of Community-Acquired Pneumonia in Emergency Departments: Comparison with Pneumonia Severity Index and CURB-65 Scores
Despite widely used severity indices such as the pneumonia severity index (PSI) and CURB-65, a rapid, easy-to-detect biological marker is required for assessment of community-acquired pneumonia (CAP) severity. We aimed to investigate the ability of presepsin to differentiate between high- and low-ri...
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| Veröffentlicht in: | Laboratory medicine 2019-11, Vol.50 (4), p.364-369 |
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| creator | Ham, Ji Yeon Song, Kyung Eun |
| description | Despite widely used severity indices such as the pneumonia severity index (PSI) and CURB-65, a rapid, easy-to-detect biological marker is required for assessment of community-acquired pneumonia (CAP) severity. We aimed to investigate the ability of presepsin to differentiate between high- and low-risk patients, categorized according to PSI and CURB-65 scores. This prospective study was performed in an emergency department (ED) with 90 CAP patients. Whole blood presepsin levels were measured with a point-of-care test instrument. Using PSI and CURB-65 scores, we classified patients into outpatient (low-score group of PSI and CURB-65) and inpatient (high-score group of PSI and CURB-65) management groups. Presepsin levels were significantly higher in CAP patients with the high-score groups compared to the corresponding low-score groups. Presepsin correlated well with low- and high-score PSI (ROC AUC: presepsin, 0.726; PCT, 0.614; CRP, 0.544) and CURB-65 groups (ROC AUC: presepsin, 0.669; PCT, 0.645; CRP, 0.602). Presepsin is a valuable biomarker for assessing and classifying CAP severity. |
| doi_str_mv | 10.1093/labmed/lmz005 |
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We aimed to investigate the ability of presepsin to differentiate between high- and low-risk patients, categorized according to PSI and CURB-65 scores. This prospective study was performed in an emergency department (ED) with 90 CAP patients. Whole blood presepsin levels were measured with a point-of-care test instrument. Using PSI and CURB-65 scores, we classified patients into outpatient (low-score group of PSI and CURB-65) and inpatient (high-score group of PSI and CURB-65) management groups. Presepsin levels were significantly higher in CAP patients with the high-score groups compared to the corresponding low-score groups. Presepsin correlated well with low- and high-score PSI (ROC AUC: presepsin, 0.726; PCT, 0.614; CRP, 0.544) and CURB-65 groups (ROC AUC: presepsin, 0.669; PCT, 0.645; CRP, 0.602). Presepsin is a valuable biomarker for assessing and classifying CAP severity.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmz005</identifier><identifier>PMID: 30892617</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis ; B cells ; Biomarkers - blood ; Community-Acquired Infections - diagnosis ; Community-Acquired Infections - pathology ; Diagnostic Tests, Routine - methods ; Emergency Medical Services - methods ; Emergency service ; Ethylenediaminetetraacetic acid ; Female ; Hospitals ; Humans ; Lipopolysaccharide Receptors - blood ; Male ; Middle Aged ; Peptide Fragments - blood ; Pneumonia ; Pneumonia - diagnosis ; Pneumonia - pathology ; Prospective Studies ; ROC Curve ; Severity of Illness Index</subject><ispartof>Laboratory medicine, 2019-11, Vol.50 (4), p.364-369</ispartof><rights>American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2019 Oxford University Press</rights><rights>American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-2b88a4b40bc28085772c8e35fea525a0fc0c7481ed55b1a1e8f88e2b603808193</citedby><cites>FETCH-LOGICAL-c388t-2b88a4b40bc28085772c8e35fea525a0fc0c7481ed55b1a1e8f88e2b603808193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30892617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ham, Ji Yeon</creatorcontrib><creatorcontrib>Song, Kyung Eun</creatorcontrib><title>A Prospective Study of Presepsin as an Indicator of the Severity of Community-Acquired Pneumonia in Emergency Departments: Comparison with Pneumonia Severity Index and CURB-65 Scores</title><title>Laboratory medicine</title><addtitle>Lab Med</addtitle><description>Despite widely used severity indices such as the pneumonia severity index (PSI) and CURB-65, a rapid, easy-to-detect biological marker is required for assessment of community-acquired pneumonia (CAP) severity. We aimed to investigate the ability of presepsin to differentiate between high- and low-risk patients, categorized according to PSI and CURB-65 scores. This prospective study was performed in an emergency department (ED) with 90 CAP patients. Whole blood presepsin levels were measured with a point-of-care test instrument. Using PSI and CURB-65 scores, we classified patients into outpatient (low-score group of PSI and CURB-65) and inpatient (high-score group of PSI and CURB-65) management groups. Presepsin levels were significantly higher in CAP patients with the high-score groups compared to the corresponding low-score groups. Presepsin correlated well with low- and high-score PSI (ROC AUC: presepsin, 0.726; PCT, 0.614; CRP, 0.544) and CURB-65 groups (ROC AUC: presepsin, 0.669; PCT, 0.645; CRP, 0.602). Presepsin is a valuable biomarker for assessing and classifying CAP severity.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>B cells</subject><subject>Biomarkers - blood</subject><subject>Community-Acquired Infections - diagnosis</subject><subject>Community-Acquired Infections - pathology</subject><subject>Diagnostic Tests, Routine - methods</subject><subject>Emergency Medical Services - methods</subject><subject>Emergency service</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lipopolysaccharide Receptors - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptide Fragments - blood</subject><subject>Pneumonia</subject><subject>Pneumonia - diagnosis</subject><subject>Pneumonia - pathology</subject><subject>Prospective Studies</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkt9v1SAUx4nRuOv00VdD4osv3SiUlvp2d526ZImLc8-E0tONpUAHdHr9w_z7pLubv2IIIefw-X7PCRyEXpbkoCQtOxxVZ6E_HO13QvgjtCrbihVNw8hjtCKENAUntNlDz2K8zmHV1vQp2mNEtLQumxX6scZnwccJdDK3gM_T3G-xH3ISIkzROKwiVg6fuN5olXxYLtNVJuEWgkl38MZbO7scFGt9M5sAPT5zMFvvjMLZ4thCuASnt_gdTCokCy7Ft4ssRyZ6h7-adPWH5pd5Lgvfcv0eby4-HxU1x-fa59aeoyeDGiO8uD_30cX74y-bj8Xppw8nm_VpoZkQqaCdEKrqKtJpKojgTUO1AMYHUJxyRQZNdFOJEnrOu1KVIAYhgHY1YRkvW7aP3ux8p-BvZohJWhM1jKNy4OcoaX5uLnh-zIy-_ge99nNwuTtJWc3zbqr2N3WpRpDGDT4FpRdTua7b3B-p2eJ18B8qrx6s0d7BYHL-L0GxE-j8mTHAIKdgrApbWRK5zInczYnczUnmX903O9-lH-iHwWA_AUvNuvE</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Ham, Ji Yeon</creator><creator>Song, Kyung Eun</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20191101</creationdate><title>A Prospective Study of Presepsin as an Indicator of the Severity of Community-Acquired Pneumonia in Emergency Departments: Comparison with Pneumonia Severity Index and CURB-65 Scores</title><author>Ham, Ji Yeon ; Song, Kyung Eun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-2b88a4b40bc28085772c8e35fea525a0fc0c7481ed55b1a1e8f88e2b603808193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>B cells</topic><topic>Biomarkers - blood</topic><topic>Community-Acquired Infections - diagnosis</topic><topic>Community-Acquired Infections - pathology</topic><topic>Diagnostic Tests, Routine - methods</topic><topic>Emergency Medical Services - methods</topic><topic>Emergency service</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lipopolysaccharide Receptors - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptide Fragments - blood</topic><topic>Pneumonia</topic><topic>Pneumonia - diagnosis</topic><topic>Pneumonia - pathology</topic><topic>Prospective Studies</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ham, Ji Yeon</creatorcontrib><creatorcontrib>Song, Kyung Eun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ham, Ji Yeon</au><au>Song, Kyung Eun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Prospective Study of Presepsin as an Indicator of the Severity of Community-Acquired Pneumonia in Emergency Departments: Comparison with Pneumonia Severity Index and CURB-65 Scores</atitle><jtitle>Laboratory medicine</jtitle><addtitle>Lab Med</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>50</volume><issue>4</issue><spage>364</spage><epage>369</epage><pages>364-369</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract>Despite widely used severity indices such as the pneumonia severity index (PSI) and CURB-65, a rapid, easy-to-detect biological marker is required for assessment of community-acquired pneumonia (CAP) severity. We aimed to investigate the ability of presepsin to differentiate between high- and low-risk patients, categorized according to PSI and CURB-65 scores. This prospective study was performed in an emergency department (ED) with 90 CAP patients. Whole blood presepsin levels were measured with a point-of-care test instrument. Using PSI and CURB-65 scores, we classified patients into outpatient (low-score group of PSI and CURB-65) and inpatient (high-score group of PSI and CURB-65) management groups. Presepsin levels were significantly higher in CAP patients with the high-score groups compared to the corresponding low-score groups. Presepsin correlated well with low- and high-score PSI (ROC AUC: presepsin, 0.726; PCT, 0.614; CRP, 0.544) and CURB-65 groups (ROC AUC: presepsin, 0.669; PCT, 0.645; CRP, 0.602). Presepsin is a valuable biomarker for assessing and classifying CAP severity.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30892617</pmid><doi>10.1093/labmed/lmz005</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Analysis B cells Biomarkers - blood Community-Acquired Infections - diagnosis Community-Acquired Infections - pathology Diagnostic Tests, Routine - methods Emergency Medical Services - methods Emergency service Ethylenediaminetetraacetic acid Female Hospitals Humans Lipopolysaccharide Receptors - blood Male Middle Aged Peptide Fragments - blood Pneumonia Pneumonia - diagnosis Pneumonia - pathology Prospective Studies ROC Curve Severity of Illness Index |
| title | A Prospective Study of Presepsin as an Indicator of the Severity of Community-Acquired Pneumonia in Emergency Departments: Comparison with Pneumonia Severity Index and CURB-65 Scores |
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