The role of emulsion parameters in tramadol sustained-release from electrospun mats
Tramadol is an analgesic usually prescribed for the management of pain, with a certain risk of addiction in chronic patients. The incorporation of tramadol in sustained-release systems results particularly attractive for the administration of accurate doses. In this work, emulsion electrospinning wa...
Gespeichert in:
Veröffentlicht in: | Materials Science & Engineering C 2019-06, Vol.99, p.1493-1501 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1501 |
---|---|
container_issue | |
container_start_page | 1493 |
container_title | Materials Science & Engineering C |
container_volume | 99 |
creator | Giannetti, R. Abraham, G.A. Rivero, G. |
description | Tramadol is an analgesic usually prescribed for the management of pain, with a certain risk of addiction in chronic patients. The incorporation of tramadol in sustained-release systems results particularly attractive for the administration of accurate doses. In this work, emulsion electrospinning was used for the preparation of tramadol-loaded nanofibrous membranes based on poly(ε-caprolactone). Compositional and processing parameters were screened and evaluated in terms of the morphology of the resulting nanofibers, encapsulation efficiency and drug release in time. The polymer concentration, surfactant type and amount, and the homogenization rate used for the emulsions preparation were found to greatly affect the fluid stability and the resulting materials structure and functionality. The intrinsic features of the starting fluid studied in this work played a significant role for the modulation of tramadol release from nanofibrous matrices. The use of sodium dodecyl sulfate as surfactant with an optimal homogenization rate allowed the preparation of electrospun fibrous membranes with good encapsulation efficiency, a minimal burst release and a sustained delivery of tramadol in time.
[Display omitted]
•Emulsion electrospun nanofibrous membranes as tramadol sustained-release systems.•Emulsion compositional and processing parameters affect the nanofibers morphology.•Tramadol release profiles are tuned by manipulating the emulsion intrinsic features. |
doi_str_mv | 10.1016/j.msec.2019.02.085 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2194585811</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0928493118300110</els_id><sourcerecordid>2212703227</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-53a8ef604be748669109afda938de1d872c7026c571128b1b75fe01b06d5b08d3</originalsourceid><addsrcrecordid>eNp9kEtr3DAURkVoSCaPP9BFEXTTjZ175Ydk6CaENi0MZJFkLWTpmmqwralkB_Lvo2HSLrroSg_O93HvYewjQomA7c2unBLZUgB2JYgSVHPCNqhkVeQf_MA20AlV1F2F5-wipR1Aqyopzth5BUp1rao37PHpF_EYRuJh4DStY_Jh5nsTzUQLxcT9zJf8MC6MPK1pMX4mV0QaySTiQwwTz3e7xJD268wns6QrdjqYMdH1-3nJnr9_e7r7UWwf7n_e3W4LWyMsRVMZRUMLdU-yVm3bIXRmcKarlCN0SgorQbS2kYhC9djLZiDAHlrX9KBcdcm-HHv3MfxeKS168snSOJqZwpq0wK5uVKMQM_r5H3QX1jjn6bQQKCRUQshMiSNl8zYp0qD30U8mvmoEfVCud_qgXB-UaxA6K8-hT-_Vaz-R-xv54zgDX48AZRcvnqJO1tNsyfmYxWkX_P_63wCTn5HX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2212703227</pqid></control><display><type>article</type><title>The role of emulsion parameters in tramadol sustained-release from electrospun mats</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Giannetti, R. ; Abraham, G.A. ; Rivero, G.</creator><creatorcontrib>Giannetti, R. ; Abraham, G.A. ; Rivero, G.</creatorcontrib><description>Tramadol is an analgesic usually prescribed for the management of pain, with a certain risk of addiction in chronic patients. The incorporation of tramadol in sustained-release systems results particularly attractive for the administration of accurate doses. In this work, emulsion electrospinning was used for the preparation of tramadol-loaded nanofibrous membranes based on poly(ε-caprolactone). Compositional and processing parameters were screened and evaluated in terms of the morphology of the resulting nanofibers, encapsulation efficiency and drug release in time. The polymer concentration, surfactant type and amount, and the homogenization rate used for the emulsions preparation were found to greatly affect the fluid stability and the resulting materials structure and functionality. The intrinsic features of the starting fluid studied in this work played a significant role for the modulation of tramadol release from nanofibrous matrices. The use of sodium dodecyl sulfate as surfactant with an optimal homogenization rate allowed the preparation of electrospun fibrous membranes with good encapsulation efficiency, a minimal burst release and a sustained delivery of tramadol in time.
[Display omitted]
•Emulsion electrospun nanofibrous membranes as tramadol sustained-release systems.•Emulsion compositional and processing parameters affect the nanofibers morphology.•Tramadol release profiles are tuned by manipulating the emulsion intrinsic features.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2019.02.085</identifier><identifier>PMID: 30889684</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Addictions ; Analgesics ; Controlled release ; Drug delivery ; Drug delivery systems ; Electrospinning ; Emulsion electrospinning ; Emulsions ; Encapsulation ; Homogenization ; Materials science ; Mats ; Membranes ; Morphology ; Nanofibers ; Pain ; Process parameters ; Sodium ; Sodium dodecyl sulfate ; Sodium lauryl sulfate ; Surfactants ; Tramadol</subject><ispartof>Materials Science & Engineering C, 2019-06, Vol.99, p.1493-1501</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jun 2019</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-53a8ef604be748669109afda938de1d872c7026c571128b1b75fe01b06d5b08d3</citedby><cites>FETCH-LOGICAL-c410t-53a8ef604be748669109afda938de1d872c7026c571128b1b75fe01b06d5b08d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2019.02.085$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30889684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giannetti, R.</creatorcontrib><creatorcontrib>Abraham, G.A.</creatorcontrib><creatorcontrib>Rivero, G.</creatorcontrib><title>The role of emulsion parameters in tramadol sustained-release from electrospun mats</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Tramadol is an analgesic usually prescribed for the management of pain, with a certain risk of addiction in chronic patients. The incorporation of tramadol in sustained-release systems results particularly attractive for the administration of accurate doses. In this work, emulsion electrospinning was used for the preparation of tramadol-loaded nanofibrous membranes based on poly(ε-caprolactone). Compositional and processing parameters were screened and evaluated in terms of the morphology of the resulting nanofibers, encapsulation efficiency and drug release in time. The polymer concentration, surfactant type and amount, and the homogenization rate used for the emulsions preparation were found to greatly affect the fluid stability and the resulting materials structure and functionality. The intrinsic features of the starting fluid studied in this work played a significant role for the modulation of tramadol release from nanofibrous matrices. The use of sodium dodecyl sulfate as surfactant with an optimal homogenization rate allowed the preparation of electrospun fibrous membranes with good encapsulation efficiency, a minimal burst release and a sustained delivery of tramadol in time.
[Display omitted]
•Emulsion electrospun nanofibrous membranes as tramadol sustained-release systems.•Emulsion compositional and processing parameters affect the nanofibers morphology.•Tramadol release profiles are tuned by manipulating the emulsion intrinsic features.</description><subject>Addictions</subject><subject>Analgesics</subject><subject>Controlled release</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Electrospinning</subject><subject>Emulsion electrospinning</subject><subject>Emulsions</subject><subject>Encapsulation</subject><subject>Homogenization</subject><subject>Materials science</subject><subject>Mats</subject><subject>Membranes</subject><subject>Morphology</subject><subject>Nanofibers</subject><subject>Pain</subject><subject>Process parameters</subject><subject>Sodium</subject><subject>Sodium dodecyl sulfate</subject><subject>Sodium lauryl sulfate</subject><subject>Surfactants</subject><subject>Tramadol</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kEtr3DAURkVoSCaPP9BFEXTTjZ175Ydk6CaENi0MZJFkLWTpmmqwralkB_Lvo2HSLrroSg_O93HvYewjQomA7c2unBLZUgB2JYgSVHPCNqhkVeQf_MA20AlV1F2F5-wipR1Aqyopzth5BUp1rao37PHpF_EYRuJh4DStY_Jh5nsTzUQLxcT9zJf8MC6MPK1pMX4mV0QaySTiQwwTz3e7xJD268wns6QrdjqYMdH1-3nJnr9_e7r7UWwf7n_e3W4LWyMsRVMZRUMLdU-yVm3bIXRmcKarlCN0SgorQbS2kYhC9djLZiDAHlrX9KBcdcm-HHv3MfxeKS168snSOJqZwpq0wK5uVKMQM_r5H3QX1jjn6bQQKCRUQshMiSNl8zYp0qD30U8mvmoEfVCud_qgXB-UaxA6K8-hT-_Vaz-R-xv54zgDX48AZRcvnqJO1tNsyfmYxWkX_P_63wCTn5HX</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Giannetti, R.</creator><creator>Abraham, G.A.</creator><creator>Rivero, G.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>The role of emulsion parameters in tramadol sustained-release from electrospun mats</title><author>Giannetti, R. ; Abraham, G.A. ; Rivero, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-53a8ef604be748669109afda938de1d872c7026c571128b1b75fe01b06d5b08d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Addictions</topic><topic>Analgesics</topic><topic>Controlled release</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Electrospinning</topic><topic>Emulsion electrospinning</topic><topic>Emulsions</topic><topic>Encapsulation</topic><topic>Homogenization</topic><topic>Materials science</topic><topic>Mats</topic><topic>Membranes</topic><topic>Morphology</topic><topic>Nanofibers</topic><topic>Pain</topic><topic>Process parameters</topic><topic>Sodium</topic><topic>Sodium dodecyl sulfate</topic><topic>Sodium lauryl sulfate</topic><topic>Surfactants</topic><topic>Tramadol</topic><toplevel>online_resources</toplevel><creatorcontrib>Giannetti, R.</creatorcontrib><creatorcontrib>Abraham, G.A.</creatorcontrib><creatorcontrib>Rivero, G.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giannetti, R.</au><au>Abraham, G.A.</au><au>Rivero, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of emulsion parameters in tramadol sustained-release from electrospun mats</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>99</volume><spage>1493</spage><epage>1501</epage><pages>1493-1501</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Tramadol is an analgesic usually prescribed for the management of pain, with a certain risk of addiction in chronic patients. The incorporation of tramadol in sustained-release systems results particularly attractive for the administration of accurate doses. In this work, emulsion electrospinning was used for the preparation of tramadol-loaded nanofibrous membranes based on poly(ε-caprolactone). Compositional and processing parameters were screened and evaluated in terms of the morphology of the resulting nanofibers, encapsulation efficiency and drug release in time. The polymer concentration, surfactant type and amount, and the homogenization rate used for the emulsions preparation were found to greatly affect the fluid stability and the resulting materials structure and functionality. The intrinsic features of the starting fluid studied in this work played a significant role for the modulation of tramadol release from nanofibrous matrices. The use of sodium dodecyl sulfate as surfactant with an optimal homogenization rate allowed the preparation of electrospun fibrous membranes with good encapsulation efficiency, a minimal burst release and a sustained delivery of tramadol in time.
[Display omitted]
•Emulsion electrospun nanofibrous membranes as tramadol sustained-release systems.•Emulsion compositional and processing parameters affect the nanofibers morphology.•Tramadol release profiles are tuned by manipulating the emulsion intrinsic features.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30889684</pmid><doi>10.1016/j.msec.2019.02.085</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0928-4931 |
ispartof | Materials Science & Engineering C, 2019-06, Vol.99, p.1493-1501 |
issn | 0928-4931 1873-0191 |
language | eng |
recordid | cdi_proquest_miscellaneous_2194585811 |
source | Elsevier ScienceDirect Journals Complete |
subjects | Addictions Analgesics Controlled release Drug delivery Drug delivery systems Electrospinning Emulsion electrospinning Emulsions Encapsulation Homogenization Materials science Mats Membranes Morphology Nanofibers Pain Process parameters Sodium Sodium dodecyl sulfate Sodium lauryl sulfate Surfactants Tramadol |
title | The role of emulsion parameters in tramadol sustained-release from electrospun mats |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T03%3A29%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20emulsion%20parameters%20in%20tramadol%20sustained-release%20from%20electrospun%20mats&rft.jtitle=Materials%20Science%20&%20Engineering%20C&rft.au=Giannetti,%20R.&rft.date=2019-06-01&rft.volume=99&rft.spage=1493&rft.epage=1501&rft.pages=1493-1501&rft.issn=0928-4931&rft.eissn=1873-0191&rft_id=info:doi/10.1016/j.msec.2019.02.085&rft_dat=%3Cproquest_cross%3E2212703227%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2212703227&rft_id=info:pmid/30889684&rft_els_id=S0928493118300110&rfr_iscdi=true |