Endothelium‐dependent relaxation mechanisms involve nitric oxide and prostanoids in the isolated bovine digital vein

Endothelial dysfunction contributes to the development of ungulate's laminitis. Although extensively studied in equines, the endothelial function is not fully examined in bovine digital veins (BDVs). BDVs were studied under isometric conditions to describe the acetylcholine (ACh) endothelium‐de...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2019-05, Vol.42 (3), p.361-367
Hauptverfasser:	Comerma‐Steffensen, Simon, Risso, Arnaldo, Ascanio‐Evanoff, Elias, Zerpa, Hector
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - pharmacology Animals bovine digital vein Cattle Cyclooxygenase Inhibitors - pharmacology Dose-Response Relationship, Drug endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiology Female Hoof and Claw - blood supply Indomethacin - pharmacology Male NG-Nitroarginine Methyl Ester - pharmacology nitric oxide Nitric Oxide - metabolism Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitroprusside - pharmacology Phenylephrine - pharmacology Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - metabolism Prostaglandins - physiology prostanoids Vasodilation Veins - drug effects Veins - metabolism Veins - physiology
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