The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function
Objective Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method We performed polysomnography (PSG) and Aβ imagin...
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| Veröffentlicht in: | Annals of nuclear medicine 2019-07, Vol.33 (7), p.541-544 |
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| container_title | Annals of nuclear medicine |
| container_volume | 33 |
| creator | Handa, Sakiko Shimizu Baba, Shingo Yamashita, Kenichiro Nishizaka, Mari Ando, Shinichi |
| description | Objective
Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.
Method
We performed polysomnography (PSG) and Aβ imaging with [
11
C]-Pittsburgh compound B PET computed tomography (
11
C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h).
Results
The abnormal accumulation of enhanced
11
C-PiB PET was observed only one patient with severe, but not the most severe.
Conclusions
The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition. |
| doi_str_mv | 10.1007/s12149-019-01349-6 |
| format | Article |
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Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.
Method
We performed polysomnography (PSG) and Aβ imaging with [
11
C]-Pittsburgh compound B PET computed tomography (
11
C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h).
Results
The abnormal accumulation of enhanced
11
C-PiB PET was observed only one patient with severe, but not the most severe.
Conclusions
The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-019-01349-6</identifier><identifier>PMID: 30887231</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Accumulation ; Aged ; Aged, 80 and over ; Amyloid - metabolism ; Aniline Compounds ; Apnea ; Brain ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - physiopathology ; Cognition ; Cognitive ability ; Computation ; Computed tomography ; Deposition ; Female ; Humans ; Imaging ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroimaging ; Nuclear Medicine ; Patients ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Radiology ; Short Communication ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - diagnostic imaging ; Sleep Apnea, Obstructive - metabolism ; Sleep Apnea, Obstructive - physiopathology ; Sleep disorders ; Thiazoles</subject><ispartof>Annals of nuclear medicine, 2019-07, Vol.33 (7), p.541-544</ispartof><rights>The Japanese Society of Nuclear Medicine 2019</rights><rights>Annals of Nuclear Medicine is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-ddbaa89872d3ab4ed97bb04399919cc72f289e6b1b7970469727929db0784b8a3</citedby><cites>FETCH-LOGICAL-c427t-ddbaa89872d3ab4ed97bb04399919cc72f289e6b1b7970469727929db0784b8a3</cites><orcidid>0000-0002-2796-0621</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-019-01349-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-019-01349-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30887231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Handa, Sakiko Shimizu</creatorcontrib><creatorcontrib>Baba, Shingo</creatorcontrib><creatorcontrib>Yamashita, Kenichiro</creatorcontrib><creatorcontrib>Nishizaka, Mari</creatorcontrib><creatorcontrib>Ando, Shinichi</creatorcontrib><title>The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Objective
Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.
Method
We performed polysomnography (PSG) and Aβ imaging with [
11
C]-Pittsburgh compound B PET computed tomography (
11
C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h).
Results
The abnormal accumulation of enhanced
11
C-PiB PET was observed only one patient with severe, but not the most severe.
Conclusions
The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.</description><subject>Accumulation</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyloid - metabolism</subject><subject>Aniline Compounds</subject><subject>Apnea</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Deposition</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Radiology</subject><subject>Short Communication</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - diagnostic imaging</subject><subject>Sleep Apnea, Obstructive - metabolism</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Sleep disorders</subject><subject>Thiazoles</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kstu1TAQhiMEoofCC7BAltiwCfjWOF7CUblIlejisEIo8i05rhI7-NIqr8kT4ZwUkFh0Ydlj__N5NPNX1UsE3yII2buIMKK8hmhdpJyaR9UOtQ2tG0rI42oHOaI1Qy07q57FeAMhbi9a_LQ6I7BtGSZoV_06HA2I5tYEmxbge-BlTCGrZG_L_WjMDMTsjABxcTr4yQAlnPMJzMFoqxJIJV8olac8imS9WxkyCOuAmJbRWw3kAuwkBusGcGfTEXxHaP-jvrYpRZnDcATKT7PPToMP4PrycApzMhokP_khiPlYAA7MBW9cihtEAOfDJMaiHpw9Vdtnp9YKnldPejFG8-J-P6--fbw87D_XV18_fdm_v6oVxSzVWkshWl76oImQ1GjOpISUcM4RV4rhHrfcNBJJxhmkDWeYccy1hKylshXkvHqzcefgf2YTUzfZqMw4Cmd8jh1GnJb5EE6L9PV_0hufgyvVdRhflEEwwsiDKsQJxRA1KwtvKhV8jMH03RxKf8PSIditvug2X3TFF93JF11Tkl7do7OcjP6b8scIRUA2QSxPbjDh398PYH8DEoDGjw</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Handa, Sakiko Shimizu</creator><creator>Baba, Shingo</creator><creator>Yamashita, Kenichiro</creator><creator>Nishizaka, Mari</creator><creator>Ando, Shinichi</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2796-0621</orcidid></search><sort><creationdate>20190701</creationdate><title>The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function</title><author>Handa, Sakiko Shimizu ; Baba, Shingo ; Yamashita, Kenichiro ; Nishizaka, Mari ; Ando, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-ddbaa89872d3ab4ed97bb04399919cc72f289e6b1b7970469727929db0784b8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Accumulation</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyloid - metabolism</topic><topic>Aniline Compounds</topic><topic>Apnea</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Computation</topic><topic>Computed tomography</topic><topic>Deposition</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Radiology</topic><topic>Short Communication</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - diagnostic imaging</topic><topic>Sleep Apnea, Obstructive - metabolism</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Sleep disorders</topic><topic>Thiazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Handa, Sakiko Shimizu</creatorcontrib><creatorcontrib>Baba, Shingo</creatorcontrib><creatorcontrib>Yamashita, Kenichiro</creatorcontrib><creatorcontrib>Nishizaka, Mari</creatorcontrib><creatorcontrib>Ando, Shinichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Handa, Sakiko Shimizu</au><au>Baba, Shingo</au><au>Yamashita, Kenichiro</au><au>Nishizaka, Mari</au><au>Ando, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>33</volume><issue>7</issue><spage>541</spage><epage>544</epage><pages>541-544</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Objective
Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.
Method
We performed polysomnography (PSG) and Aβ imaging with [
11
C]-Pittsburgh compound B PET computed tomography (
11
C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h).
Results
The abnormal accumulation of enhanced
11
C-PiB PET was observed only one patient with severe, but not the most severe.
Conclusions
The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>30887231</pmid><doi>10.1007/s12149-019-01349-6</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-2796-0621</orcidid></addata></record> |
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| ispartof | Annals of nuclear medicine, 2019-07, Vol.33 (7), p.541-544 |
| issn | 0914-7187 1864-6433 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Accumulation Aged Aged, 80 and over Amyloid - metabolism Aniline Compounds Apnea Brain Brain - diagnostic imaging Brain - metabolism Brain - physiopathology Cognition Cognitive ability Computation Computed tomography Deposition Female Humans Imaging Male Medical imaging Medicine Medicine & Public Health Middle Aged Neuroimaging Nuclear Medicine Patients Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography Radiology Short Communication Sleep Sleep apnea Sleep Apnea, Obstructive - diagnostic imaging Sleep Apnea, Obstructive - metabolism Sleep Apnea, Obstructive - physiopathology Sleep disorders Thiazoles |
| title | The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function |
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