Delayed daily activity and reduced NREM slow-wave power in the APPswe/PS1dE9 mouse model of Alzheimer's disease

Alzheimer's disease (AD) is associated with disrupted circadian rhythms and sleep, which are thought to reflect an impairment of internal circadian timekeeping that contribute to clinical symptoms and disease progression. To evaluate these hypotheses, a suitable preclinical model of AD is neede...

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Veröffentlicht in:	Neurobiology of aging 2019-06, Vol.78, p.74-86
Hauptverfasser:	Kent, Brianne A., Michalik, Mateusz, Marchant, Elliott G., Yau, Kiana W., Feldman, Howard H., Mistlberger, Ralph E., Nygaard, Haakon B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Circadian rhythms EEG Power spectra Sleep Transgenic model
Online-Zugang:	Volltext
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